Cardiac left ventricular hypertrophy and chamber dilatation in panic disorder patients: Implications for idiopathic dilated cardiomyopathy

Kahn, Jeffrey P.; Gorman, Jack M.; King, Donald L.; Fyer, Abby J.; Liebowitz, Michael R.; Klein, Donald F.

doi:10.1016/0165-1781(90)90135-r

Cited by 29 publications

(14 citation statements)

References 15 publications

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“…This again underscores the importance of QT variability as a novel measure of ventricular repolarization, which might yield additional information to that of HR or QT variability alone. These findings are also important as two previous reports suggested a possible increase in left ventricular mass in patients with panic disorder [46,47].…”

Section: Discussionsupporting

confidence: 49%

Twenty-Four-Hour QT Interval Variability: Increased QT Variability during Sleep in Patients with Panic Disorder

et al. 2002

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Recent studies on beat-to-beat QT interval variability (QTV) have shown that it can be used as a noninvasive measure of cardiac repolarization lability. It is also a predictor of sudden cardiac death and is higher in patients with anxiety and depression. This study examined the diurnal measures in QTV in 32 normal adults and 22 patients using 24-hour electrocardiogram records. We obtained 8 5-min segments of ECG sampled at 1,000 Hz from the 24-hour records. Our results show that QTV measures at nighttime are significantly higher in patients with panic disorder compared with controls. These findings demonstrate blunted diurnal changes in ventricular repolarization lability in patients resulting in a higher QT variability index during sleep. We speculate that these effects may relate to a relative increase in cardiac sympathetic activity in patients with panic disorder, and may contribute to the increased risk for cardiac mortality in patients with anxiety.

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Section: Discussionsupporting

confidence: 49%

Twenty-Four-Hour QT Interval Variability: Increased QT Variability during Sleep in Patients with Panic Disorder

et al. 2002

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“…As patients in our study did not undergo echo cardiography, we cannot exclude the possibility that the observed leftward shift of the R-wave axis may represent subclinical left ventricular changes in these patients. In fact Kahn et al [7] previously reported an association between panic disorder and idiopathic dilated cardio myopathy. However, in the absence of hypertension and other cardiac conditions, a leftward shift of R-wave axis could be a potential peripheral marker for panic disorder and depression.…”

Section: Discussionmentioning

confidence: 99%

Leftward Shift of R-Axis on Electrocardiogram in Patients with Panic Disorder and Depression

Yeragani

Baton²,

Pohl³

et al. 1992

Neuropsychobiology

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In a prospective study, we have compared R-axis on routine electrocardiograms of panic disorder patients (n = 52) with that of depressed patients (n = 41) and normal controls (n = 65). All subjects were physically healthy and were normotensive. There was a significant leftward shift of R-axis in both depressed and panic disorder patients compared to normal controls. The implications of these findings are discussed.

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“…28 Panic disorder has also been associated with increased left ventricular mass and diameter. 83 In addition, patients with panic disorder have poorer cardiovascular fitness, as demonstrated by lower Vo 2 max and decreased exercise tolerance compared with control subjects. 84 Although panic disorder is reportedly associated with idiopathic cardiomyopathy, 85 not all studies support this.…”

Section: Panic Disorder and Cardiac Diseasementioning

confidence: 99%

Panic & Plaques: Panic Disorder & Coronary Artery Disease in Patients with Chest Pain

Katerndahl

2004

The Journal of the American Board of Family Medicine

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Background:The purpose of this systematic review was to identify characteristics of the chest pain associated with the presence of panic disorder, to determine the strength of the association between panic disorder and coronary artery disease (CAD), and to determine the association between panic disorder and known cardiovascular risk factors.Methods: Potential studies were identified via computerized search using MEDLINE and PSYCINFO databases, and review of bibliographies. MeSH headings used included "panic disorder" with "chest pain," "panic disorder" with "coronary disease or cardiovascular disorders or heart disorders," and "panic disorder" with "cholesterol or essential hypertension or tobacco smoking." Studies had to base their diagnosis of panic disorder on criteria from the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, and objective criteria of CAD and risk factors had to be used. Only case-control and cohort studies were included.Results

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Cardiac left ventricular hypertrophy and chamber dilatation in panic disorder patients: Implications for idiopathic dilated cardiomyopathy

Cited by 29 publications

References 15 publications

Twenty-Four-Hour QT Interval Variability: Increased QT Variability during Sleep in Patients with Panic Disorder

Twenty-Four-Hour QT Interval Variability: Increased QT Variability during Sleep in Patients with Panic Disorder

Leftward Shift of R-Axis on Electrocardiogram in Patients with Panic Disorder and Depression

Panic & Plaques: Panic Disorder & Coronary Artery Disease in Patients with Chest Pain

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