Leftward Shift of R-Axis on Electrocardiogram in Patients with Panic Disorder and Depression

Yeragani, Vikram K.; Baton, Richard; Pohl, Robert; Weinberg, Paula; Thomas, Sheila M.

doi:10.1159/000118814

Cited by 1 publication

(1 citation statement)

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“…This again underscores the importance of QT variability as a novel measure of ventricular repolarization, which might yield additional information to that of HR or QT variability alone. These findings are also important as two previous reports suggested a possible increase in left ventricular mass in patients with panic disorder [46,47].…”

Section: Discussionsupporting

confidence: 56%

Twenty-Four-Hour QT Interval Variability: Increased QT Variability during Sleep in Patients with Panic Disorder

et al. 2002

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Recent studies on beat-to-beat QT interval variability (QTV) have shown that it can be used as a noninvasive measure of cardiac repolarization lability. It is also a predictor of sudden cardiac death and is higher in patients with anxiety and depression. This study examined the diurnal measures in QTV in 32 normal adults and 22 patients using 24-hour electrocardiogram records. We obtained 8 5-min segments of ECG sampled at 1,000 Hz from the 24-hour records. Our results show that QTV measures at nighttime are significantly higher in patients with panic disorder compared with controls. These findings demonstrate blunted diurnal changes in ventricular repolarization lability in patients resulting in a higher QT variability index during sleep. We speculate that these effects may relate to a relative increase in cardiac sympathetic activity in patients with panic disorder, and may contribute to the increased risk for cardiac mortality in patients with anxiety.

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Section: Discussionsupporting

confidence: 56%