Cardiac Immunology: A New Era for Immune Cells in the Heart

Koc, Arzuhan; Çağavı, Esra

doi:10.1007/5584_2020_576

Cited by 8 publications

(8 citation statements)

References 95 publications

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“… 79 , 80 It is worth noting that the heart in a state of relative immune privilege is not equal to an immunodeficient organ. 81 , 82 Although there are very few T cells found in a healthy heart, there are numbers of tissue-resident macrophages and dendritic cells (DCs) throughout the healthy heart and lodged between cardiomyocytes to form an immune network to participate in initiating effector T cell responses, tissue repairment, immune regulation, and tolerance. 81 , 83 In the pathophysiology of ICIs-induced myocarditis, the changes in the abundance, distribution, polarization, and diversity of immune cells reveal that adaptive immunity plays a critical role in such kinds of irAEs 67 , 84 ( Fig.…”

Section: How Do Icis Break the Heart?mentioning

confidence: 99%

Immune checkpoint inhibitors break whose heart? Perspectives from cardio-immuno-oncology

Huang

Dai

et al. 2024

Genes & Diseases

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Section: How Do Icis Break the Heart?mentioning

confidence: 99%

Immune checkpoint inhibitors break whose heart? Perspectives from cardio-immuno-oncology

Huang

Dai

et al. 2024

Genes & Diseases

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“…Previous studies have shown that immune cells play an important role in the occurrence and development of AF. Some studies have identi ed the large distribution of immune cells in the heart, especially in the atrial tissue, with 30.1% cardiomyocytes, 24.3% broblasts and 10.4% immune cells in the atrial samples, indicating the importance of local immune cells in the pathophysiological changes of the heart [50]. Different types of activated immune cells can induce in ammation by secreting in ammatory factors, or directly participate in cell clearance, scar repair and other processes to mediate atrial remodeling [51].…”

Section: The a Nity Between Biomarkers And Their Corresponding Compou...mentioning

confidence: 99%

To explore the active ingredients and potential targets of Tongmai Yangxin pills in the treatment of atrial fibrillation based on network pharmacology and Mendelian randomization

Wang,

Xing

2024

Preprint

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Background: Atrial fibrillation (AF) is a common clinical arrhythmia. Tongmai Yangxin Pill (TMYX) is a traditional Chinese medicine prescription for treating arrhythmia, but the mechanism of action in AF remains unclear. Therefore, this study aimed to explore the mechanism of TMYX in AF and provide a new treatment target. Methods: The effective components of TMYXwere screened in onlinedatabase. Differentially expressed genes (DEGs) between AF and control samples were obtained via differential expression analysis. Candidate genes were obtained by overlapping DEGs and independent drug targets obtained by screening. Subsequently, these candidate genes were included in Mendelian randomization (MR) analysis to obtain candidate key genes. Through machine learning algorithms, candidate key genes were further screened to obtain biomarkers. Furthermore, immune infiltration analysis and molecular docking were implemented. Results: By intersecting 2,845 DEGs and 1,099 independent drug targets, 174 candidate genes were obtained. A sum of 14 candidate key genes were identified to be causally related to AF. Notably, KMO, SERPINE1, CYP17A1 and HSD17B1 were identified as biomarkers. We found regulatory T cell showed a significant positive correlation with four biomarkers. Through a series of screening, a drugs-compounds-biomarkers network containing 4 biomarkers, 8 drugs, and 26 compounds was constructed. In this network, Ophiopogonis Radix targeted CYP17A1, HSD17B1 and SERPINE1 simultaneously through different compounds. The molecular docking binding energy between these compounds and biomarkers was stable, such as SERPINE1and quercetin. Conclusion: In this study, four biomarkers were identified, which provided a new treatment target for AF.

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Section: Immune System In Artery and Heart Homeostasis And Diseasementioning

confidence: 99%

“…The heterogeneity and role of cardiac immune cells in homeostasis and heart pathology, including MI, conduction disorders, myocarditis, and endocarditis, have been extensively reviewed elsewhere. 129,130 The arterial wall also contains resident innate immune cells, including macrophages and dendritic cells, but their role in artery physiology only recently started to be acknowledged. In contrast, monocytes, macrophages, and neutrophils, are well known for their roles in the initiation, progression, and destabilization of atherosclerotic lesions.…”

Section: Immune System In Artery and Heart Homeostasis And Diseasementioning

confidence: 99%

Cardiovascular Brain Circuits

Mohanta

Yin

Weber

et al. 2023

Circulation Research

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The cardiovascular system is hardwired to the brain via multilayered afferent and efferent polysynaptic axonal connections. Two major anatomically and functionally distinct though closely interacting subcircuits within the cardiovascular system have recently been defined: The artery-brain circuit and the heart-brain circuit. However, how the nervous system impacts cardiovascular disease progression remains poorly understood. Here, we review recent findings on the anatomy, structures, and inner workings of the lesser-known artery-brain circuit and the better-established heart-brain circuit. We explore the evidence that signals from arteries or the heart form a systemic and finely tuned cardiovascular brain circuit: afferent inputs originating in the arterial tree or the heart are conveyed to distinct sensory neurons in the brain. There, primary integration centers act as hubs that receive and integrate artery-brain circuit–derived and heart-brain circuit–derived signals and process them together with axonal connections and humoral cues from distant brain regions. To conclude the cardiovascular brain circuit, integration centers transmit the constantly modified signals to efferent neurons which transfer them back to the cardiovascular system. Importantly, primary integration centers are wired to and receive information from secondary brain centers that control a wide variety of brain traits encoded in engrams including immune memory, stress-regulating hormone release, pain, reward, emotions, and even motivated types of behavior. Finally, we explore the important possibility that brain effector neurons in the cardiovascular brain circuit network connect efferent signals to other peripheral organs including the immune system, the gut, the liver, and adipose tissue. The enormous recent progress vis-à-vis the cardiovascular brain circuit allows us to propose a novel neurobiology-centered cardiovascular disease hypothesis that we term the neuroimmune cardiovascular circuit hypothesis.

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Cardiac Immunology: A New Era for Immune Cells in the Heart

Cited by 8 publications

References 95 publications

Immune checkpoint inhibitors break whose heart? Perspectives from cardio-immuno-oncology

Immune checkpoint inhibitors break whose heart? Perspectives from cardio-immuno-oncology

To explore the active ingredients and potential targets of Tongmai Yangxin pills in the treatment of atrial fibrillation based on network pharmacology and Mendelian randomization

Cardiovascular Brain Circuits

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