Cardiac Functional and Morphologic Changes of Renal Allograft Recipients in the Early Posttransplant Period

Iqbal, Masud; Banerjee, Sajal Krishna; Rahman, Md. Hamidur; Rashid, HU

doi:10.1016/j.transproceed.2006.10.044

Cited by 7 publications

(4 citation statements)

References 9 publications

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“…Iqbal et al[22] 2006 stated that marked beneficial alterations in cardiac function and morphology become apparent as early as three months post renal transplantation.…”

Section: Discussionmentioning

confidence: 99%

Impact of renal transplantation on cardiac morphological and functional characteristics in children and adults

El-Khashab¹,

Mohamed²,

Soliman³

et al. 2016

WJN

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AIMTo compare the effects of renal transplantation on cardiac functions in children and adults.METHODSOne hundred and ten patients attending the nephrology outpatient clinic were enrolled in this study and were divided into six groups. The first two groups consisted each of 30 renal transplant patients who had a successful renal transplantation more than six months, but less than one year. Group I were less than 18 years and group II were more than 18 years. The third and fourth groups, each were 20 chronic renal failure patients on regular hemodialysis. Again, group III were less than 18 years and group IV were more than 18 years. Group V and VI (The control Groups) consisted each of 5 subjects below and above 18 years of age, respectively with normal kidney functions. All patients were subjected to history and examination. The kidney functions and the hemoglobin were analyzed. After obtaining informed consent, echocardiography was done to all patients.RESULTSThere was a statistically significant improvement (P < 0.0001) in all cardiac parameters. A regression in left ventricular end diastolic volume (LVED) both in children (4.7 ± 0.8 to 4.2 ± 0.5) and in adults (5.9 ± 0.7 to 4.9 ± 0.6) were found. There was a regression in left ventricular end systolic volume (LVES) both in children (3.1 ± 0.6 to 2.4 ± 0.4) and in adults (4.1 ± 0.9 to 3.1 ± 0.5). Fractional shortening improves both in children (32.6 ± 5.3 to 41.7 ± 7.6) and in adults (29.0 ± 6.6 to 36.5 ± 4.1). The improvement in ejection fraction (EF) was higher in children (59.7 ± 7.0 to 71.9 ± 6.1) than in adults (52.0 ± 12.5 to 64.8 ± 5.9). However, this degree of improvement (in children: 12.2 ± 5.1) did not show statistical difference (P-value 0.8), when compared to adults (12.7 ± 9.8).CONCLUSIONAfter renal transplantation cardiac functions and morphology (EF/LVED/LVES) do improve markedly and rapidly in both children and adults.

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“…Iqbal et al[22] 2006 stated that marked beneficial alterations in cardiac function and morphology become apparent as early as three months post renal transplantation.…”

Section: Discussionmentioning

confidence: 99%

Impact of renal transplantation on cardiac morphological and functional characteristics in children and adults

El-Khashab¹,

Mohamed²,

Soliman³

et al. 2016

WJN

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“…These findings possibly resulted from an improvement in volume overload after transplantation. Iqbal et al similarly found a significant decrease in LAD, LVDD, and LV end diastolic volume index after kidney transplantation (19).…”

Section: Dıscussıonmentioning

confidence: 88%

“…Data expressed as mean± SD, P<0.05 was accepted as a statistically significant Rtx: Renal transplantation, e: peak early diastolic mitral inflow velocity, a: peak late diastolic mitral inflow velocity, ea: early diastolic myocardial velocity, Dt: E wave deceleration time, ivRt: isovolemic relaxation time, PVS: pulmonary vein peak systolic velocity, Pvd: pulmonary vein peak diastolic velocity. In many studies it was found that LVMI was significantly decreased after kidney transplantation (18,19), whereas some studies did not observe this improvement (9,10). In the development of LVH in patients with ESRD, there are several risk factors including uremic toxins, older age, anemia, hypoalbuminemia, hyperparathyroidism, arteriovenous fistula, hypertension, diabetes, and volume overload (3,4,20).…”

Section: Dıscussıonmentioning

confidence: 99%

Effects of Renal Transplantation on Cardiac Function and Morphology in the Late Posttransplant Period

Koçyiğit¹,

Ünal²,

Çelik³

et al. 2012

Turk Neph Dial Transpl

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OBJECTIVE: To investigate the effects of renal transplantation on left ventricular (LV) function and morphology in patients with end-stage renal disease (ESRD) in the late posttransplant period.MATERIAL and METHODS: The prospective study included 40 patients (mean age 33.2 ± 7.7 years;25 female /15 male) with ESRD. In all of these patients, renal transplantation was performed successfully; and the serum creatinine levels were less than 2 mg/dL. The echocardiographic evaluations were performed before renal transplantation and 12. month after renal transplantation. Left ventricular diastolic diameter (LVDD), left ventricular systolic diameter (LVESD), left ventricular mass (LV Mass), left ventricular mass index (LVMI), LV ejection fraction (LVEF), Doppler and tissue Doppler parameters were obtained in all patients.RESULTS: At the twelfth month, LVDD (48 ± 5 vs 45 ± 6, p: 0.01), LVSD (33 ± 4 vs 29 ± 4, p< 0.001) LVMI (114 ± 31 vs 98 ± 13, p: 0.007) decreased significantly compared to the pretransplant period. There was a significant increase in the LVEF in at the twelfth month (59 ± 5 vs 67 ± 6, p< 0.001). There was a significant improvement between pretransplant period and late posttransplant period with regard to diastolic cardiac function.CONCLUSION: Renal transplantation had beneficial effects on diastolic and systolic functions and cardiac morphology in the late posttransplant period

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“…Recently, Chen et al (25) reported that LA2D was predictive of GFR decline in patients with chronic native kidney disease (27,28) showed improvements in cardiac parameters during the first year after renal transplantation. Most of the time, left atrial volume is considered the preferred parameter over LA2D.…”

Section: Discussionmentioning

confidence: 99%

Left Atrial Diameter and Survival among Renal Allograft Recipients

Kainz

Goliasch

Wiesbauer

et al. 2013

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives Sequential echocardiography is routinely performed in patients with ESRD listed for transplantation. The benefit of this labor-and time-intensive measure, however, remains unclear. Thus, this study elucidated the various obtained routine echocardiography parameters that best predicted mortality and graft survival after renal transplantation.Design, setting, participants, & measurements This study investigated 553 first renal transplant recipients listed in the Austrian Dialysis and Transplant Registry between 1992 and 2011 who had echocardiographic analysis at transplantation and survived at least 1 year. Cox proportional hazards models with the purposeful selection algorithms for covariables were used to identify predictors of mortality and graft loss. A Fine and Gray model was used to evaluate cause-specific death.Results During a median follow-up of 7.14 years, 81 patients died, and 59 patients experienced graft loss after the first year. The Kaplan-Meier analysis showed that 85% of patients with a left atrial diameter below the median of 53 mm were alive 10 years after transplantation, whereas only 70% of those patients with a left atrial diameter equal to or above the median had survived (P,0.001). In the multivariable model, left atrial diameter (per millimeter) independently predicted overall mortality (hazard ratio, 1.06; 95% confidence interval, 1.03 to 1.08; P,0.001) and cause-specific cardiac death (hazard ratio, 1.04; 95% confidence interval, 1.00 to 1.08; P=0.04). Functional graft loss was predicted by the right atrial diameter (hazard ratio, 1.04; 95% confidence interval, 1.02 to 1.07; P=0.001). ConclusionThe left atrial diameter determined at transplantation predicted overall and cardiac mortality. Patients with widely enlarged left atria exhibit a considerably reduced life expectancy. It remains to be determined, however, whether renal transplantation is futile in these patients.

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Cardiac Functional and Morphologic Changes of Renal Allograft Recipients in the Early Posttransplant Period

Cited by 7 publications

References 9 publications

Impact of renal transplantation on cardiac morphological and functional characteristics in children and adults

Impact of renal transplantation on cardiac morphological and functional characteristics in children and adults

Effects of Renal Transplantation on Cardiac Function and Morphology in the Late Posttransplant Period

Left Atrial Diameter and Survival among Renal Allograft Recipients

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