Impact of renal transplantation on cardiac morphological and functional characteristics in children and adults

Abstract

AIMTo compare the effects of renal transplantation on cardiac functions in children and adults.METHODSOne hundred and ten patients attending the nephrology outpatient clinic were enrolled in this study and were divided into six groups. The first two groups consisted each of 30 renal transplant patients who had a successful renal transplantation more than six months, but less than one year. Group I were less than 18 years and group II were more than 18 years. The third and fourth groups, each were 20 chronic renal failure patients on regular hemodialysis. Again, group III were less than 18 years and group IV were more than 18 years. Group V and VI (The control Groups) consisted each of 5 subjects below and above 18 years of age, respectively with normal kidney functions. All patients were subjected to history and examination. The kidney functions and the hemoglobin were analyzed. After obtaining informed consent, echocardiography was done to all patients.RESULTSThere was a statistically significant improvement (P < 0.0001) in all cardiac parameters. A regression in left ventricular end diastolic volume (LVED) both in children (4.7 ± 0.8 to 4.2 ± 0.5) and in adults (5.9 ± 0.7 to 4.9 ± 0.6) were found. There was a regression in left ventricular end systolic volume (LVES) both in children (3.1 ± 0.6 to 2.4 ± 0.4) and in adults (4.1 ± 0.9 to 3.1 ± 0.5). Fractional shortening improves both in children (32.6 ± 5.3 to 41.7 ± 7.6) and in adults (29.0 ± 6.6 to 36.5 ± 4.1). The improvement in ejection fraction (EF) was higher in children (59.7 ± 7.0 to 71.9 ± 6.1) than in adults (52.0 ± 12.5 to 64.8 ± 5.9). However, this degree of improvement (in children: 12.2 ± 5.1) did not show statistical difference (P-value 0.8), when compared to adults (12.7 ± 9.8).CONCLUSIONAfter renal transplantation cardiac functions and morphology (EF/LVED/LVES) do improve markedly and rapidly in both children and adults.

Comparison of left ventricular subclinical systolic dysfunction between hemodialysis patients and renal transplant recipients using real time three‐dimensional echocardiography

“…In our study, hemodialysis patients’ LV diastolic and systolic volume indices were higher than renal transplant and control groups. This finding was compatible with literature 24 . However, LVEF results of study groups were not significantly different.…”

“…This finding was compatible with literature. 24 However, LVEF results of study groups were not significantly different.…”

Impacto del trasplante renal en la función ventricular izquierda medida por ecocardiografía y electrocardiografía en una Unidad de Tercer Nivel

“…El-Khashab SO y colaboradores refieren una reducción de 30% del grosor del SIV y la PP a dos años. 7 Nosotros observamos que esa reducción se establece desde los seis meses, siendo a los dos años de 19%. Sin embargo, en relación al porcentaje de pacientes que presentan esta reducción, observamos que de 91% que tenían HVI, a los dos años sólo 60% de pacientes la presentaban.…”