Cardiac effects of anabolic steroids

Payne, John; Kotwinski, Paul; Montgomery, Hugh

doi:10.1136/hrt.2003.025783

Cited by 102 publications

(83 citation statements)

References 18 publications

(14 reference statements)

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“…However, studies (18)(19)(20)(21)(22)(23)31,32) on the influence of the AAS use on these variables, especially concerning the cardiovascular system, have presented different results since the effect of these drugs depend on, for instance, the kind of anabolic steroid, dose, period of use and administration means of the drug, besides the species, age, sex, training level and other variables associated with the animal.…”

Section: Discussionmentioning

confidence: 99%

Decanoato de nandrolona aumenta a parede ventricular esquerda, mas atenua o aumento da cavidade provocado pelo treinamento de natação em ratos

Soares

Abreu

Assenço

et al. 2011

Rev Bras Med Esporte

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Anabolic androgen steroids (AASs) are drugs synthesized from testosterone. Their anabolic action is mainly due to increased synthesis and reduced degradation of muscle proteins. The purpose of this study was to investigate the effects of swimming training associated to nandrolonedecanoate treatment on the blood pressure, the myocardial dimensions, vascular reactivity. Forty Wistar male rats, aged 60 days, were divided into 4 groups (n = 10): sedentary (SN), sedentary treated (ST), trained (TN) and trained treated (TT). TN and TT animals performed a swimming training during 12 weeks and ST and TT animals received weekly nandrolonedecanoate (15mg/kg). The heart and testicles were removed and weighted. The left ventricular diameter (LVD) and left ventricular wall thickness (LVWT) had been measured with an electronic pachymeter. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) was weekly measured, while the mesenteric arteries vascular reactivity was studied for its response to noradrenaline. There were no alterations in the heart weight, but the LVD increased (p < 0.05) in TN rats, while the LVWT increased (p < 0.05) in ST and TT rats, both in relation to SN. Testicle weight decreased (p < 0.05) in the ST and TT animals in relation to SN. There was no alteration in blood pressure, neither in vascular reactivity. It was concluded that swimming training increased the left ventricular diameter, while nandrolonedecanoate treatment increased mainly the left ventricular wall thickness, suggesting concentric hypertrophy.

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Section: Discussionmentioning

confidence: 99%

Decanoato de nandrolona aumenta a parede ventricular esquerda, mas atenua o aumento da cavidade provocado pelo treinamento de natação em ratos

Soares

Abreu

Assenço

et al. 2011

Rev Bras Med Esporte

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“…In brief, these adverse effects include cardiovascular dysfunction (Lane, Grace, Smith, Morris, Cockcroft, Scanlon, et al, 2006;Nottin, Nguyen, Terbah, & Obert, 2006), liver dysfunction (Kafrouni, Anders, & Verma, 2007), reproductive difficulties (Knuth, Maniera, & Nieschlag, 1989) and suicide (Middleman, Faulkner, Woods, Emans, & DuRant, 1995;Pärssinen, Kujala, Vartiainen, Sarna, & Seppälä, 2000). A thorough analysis of the adverse effects of AS misuse is presented elsewhere (see Kanayama et al, 2008;Modlinski & Fields, 2006;Payne, Kotwinski, & Montgomery, 2004;Pope, Wood, Rogol, Nyberg, Bowers, & Bhasin, 2014) and these analyses suggest the misuse of ASs by adolescents may pose significant health consequences. Thus, there is general consensus in the medical and professional community that misuse of ASs by adolescents should be prevented (American College of Sports Medicine 2004; American Academy of Pediatrics, 2005).…”

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confidence: 99%

Review of the literature on negative health risks based interventions to guide anabolic steroid misuse prevention

Petróczi

Dodge

Backhouse

et al. 2014

Performance Enhancement & Health

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“…In this regard, escalating attention has focused on the effects of steroid hormones on physiological and pathological cardiac growth. If AAS is associated with an exaggerated cardiac hypertrophic response to training, athletes may be more prone to cardiac failure [45,46]. Special attention should be paid to athletes who have been using them without prescription, with the purpose of increasing muscle mass or to improve physical performance.…”

Section: Discussionmentioning

confidence: 99%

Cardiac hypertrophy and IGF-1 response to testosterone propionate treatment in trained male rats

Żebrowska¹,

Sadowska-Krępa²,

Jagsz³

et al. 2017

Open Life Sciences

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Abstract:Objective: Several studies have suggested that testosterone exerts a growth-promoting effect in the heart. Limited data are available regarding interactions between possible endocrine/paracrine effects in response to exercise training. Therefore, we examined supraphysiological testosterone-induced heart hypertrophy and cardiac insulin-like growth factor (IGF)-1 content in sedentary and exercise-trained rats. Design: Male Wistar rats (n=33) were randomly allocated to groups with a 6-week endurance training with or without testosterone, and sedentary animals with or without testosterone. The hormone (20 mg/250 g body weight was administrated once a week for six weeks. After six weeks the animals were anesthetized, euthanized and the heart was excised and weighed. The left ventricle was separated for biochemical analyses. Results: Testosterone-treated animals showed significantly higher cardiac IGF-1 content compared to untreated control and trained groups (p=0.01). The administration of supraphysiological testosterone significantly increased the heart weight to body weight ratio (HW/BW, p<0.01). A significant positive correlation was seen between IGF-1 levels and the HW/BW ratio (p=0.002; r=0.50) and between serum total testosterone levels and HW/BW (p=0.000; r=0.79). Conclusions:The results demonstrate that increased

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Cardiac effects of anabolic steroids

Abstract: Anabolic steroid abuse in athletes has been associated with a wide range of adverse conditions, including hypogonadism, testicular atrophy, impaired spermatogenesis, gynaecomastia, and psychiatric disturbance. But what effect does steroid abuse have on the cardiovascular system?

Cited by 102 publications

References 18 publications

Decanoato de nandrolona aumenta a parede ventricular esquerda, mas atenua o aumento da cavidade provocado pelo treinamento de natação em ratos

Decanoato de nandrolona aumenta a parede ventricular esquerda, mas atenua o aumento da cavidade provocado pelo treinamento de natação em ratos

Review of the literature on negative health risks based interventions to guide anabolic steroid misuse prevention

Cardiac hypertrophy and IGF-1 response to testosterone propionate treatment in trained male rats

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