Decanoato de nandrolona aumenta a parede ventricular esquerda, mas atenua o aumento da cavidade provocado pelo treinamento de natação em ratos

Soares, Maísa Carvalho Rezende; Abreu, Iracelle Carvalho; Assenço, Florentino; Borges, Marilene Oliveira da Rocha

doi:10.1590/s1517-86922011000600011

Cited by 10 publications

(7 citation statements)

References 33 publications

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“…Consistent with our findings, other studies have shown that chronic administration of nandrolone along with exercise is associated with significant increase in heart hypertrophy index (25,(28)(29)(30). They showed that reninangiotensin system activity has increased, which can justify the hypertrophic induction during exercise conditions with consumption of nandrolone.…”

Section: Discussionsupporting

confidence: 93%

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Nandrolone plus moderate exercise increases the susceptibility to lethal arrhythmias

Joukar¹,

Baravati²,

Fathpour³

et al. 2015

Res Cardiovasc Med

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Background: Until now, no experimental study has directly assessed the arrhythmogenesis of chronic consumption of anabolic androgenic steroids along with moderate-intensity endurance exercise. Objectives: We evaluated the influence of integration of anabolic androgenic steroids along with moderate-intensity endurance exercise on susceptibility to lethal ventricular arrhythmias in rat. Materials and Methods:The animal groups were as follows: control group (CTL); exercise group (EX) which were under 6 weeks of treadmill exercise; nandrolone group (Nan) which received 5 mg/kg of nandrolone decanoate twice a week; vehicle group (Arach) which received Arachis oil (solvent of nandrolone); trained vehicle group (Arach + Ex); and trained nandrolone group (Nan + Ex). One day after ending of the intervention period, arrhythmia was inducted by intravenous infusion of aconitine and ventricular arrhythmias were recorded. Then malondialdehyde (MDA) and glutathione peroxidase (GPX) of heart tissue were measured. Results: Nandrolone, exercise, and their combination were associated with heart hypertrophy. Exercise could prevent the incremental effect of nandrolone on MDA/GPX ratio. Chronic administration of nandrolone with moderate-intensity endurance exercise had no significant effect on blood pressure, heart rate, and basal electrocardiographic parameters. Combination of nandrolone and exercise significantly increased the incidence of ventricular fibrillation (VF) and reduced the VF latency (P < 0.05). Conclusions:The findings suggest that chronic coadministration of nandrolone with moderate-intensity endurance exercise facilitates the VF occurrence in rat. Complementary studies are needed to elucidate the involved mechanisms of this abnormality.

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Section: Discussionsupporting

confidence: 93%

“…It was also reported that chronic administration of nandrolone and swimming exercise, alone or in combination, have no effect on BP (29,45). However, previous studies showed that in hypertensive mice, endurance exercise could significantly reduce BP (46,47).…”

Section: Discussionmentioning

confidence: 99%

Nandrolone plus moderate exercise increases the susceptibility to lethal arrhythmias

Joukar¹,

Baravati²,

Fathpour³

et al. 2015

Res Cardiovasc Med

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“…[21][22][23] Nonetheless, some authors suggested that the decrease in the diameter of the left ventricle in female animals under supraphysiological doses of the AAS could be due to an increase in the left ventricular wall, leading to a decrease in the ventricular chamber volume with consequent hypertension, resulting in heart failure and left ventricular hypertrophy. 24,25 Another hypothesis that would lead to an increase of muscle mass in females would be based on the same reason observed by Hayward et al, 26 who administered AAS to women and consequently observed an increase in cardiac muscle mass. This could explain the findings of increased muscle mass with a consequent decrease in diameter in females, in this study, in addition to the fact that the drugs themselves lead to an increase in ventricular mass.…”

Section: Discussionmentioning

confidence: 84%

Effects of Supraphysiological Doses of Anabolic Androgenic Steroids on the Left Ventricles of Male and Female Mice Submitted to Swimming

et al. 2019

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The use of anabolic androgenic steroids (AAS) has grown into a worldwide substance abuse problem over the last decades, with the doses taken by illegal users being 10 to 100 times higher than the therapeutic ones. In the present experiment, 60 mice were divided into 3 groups of 20 animals. Group 1 received testosterone cypionate (Deposteron [EMS, São Bernardo do Campo, SP, Brazil]); group 2 received stanozolol (Stanozolol Depot, Landerlan, Lambaré, Paraguay), and group 3 received saline solution), each one composed by 10 males and 10 females, treated once a week and put to swimming thrice a week for 2 months. After euthanasia, their chests were opened, the hearts removed and processed histologically for morphometric analyses. The specimens were cut into 6 different sections and each one was measured with the help of an optical microscope with a 40-fold magnification. For such analyses, the Axiovision Rel. 4.8.2 (Carl Zeiss Microscopy LLC, Peabody, MA, USA) and Axiovision 4 Module Interactive Measurement (Carl Zeiss Microscopy LLC) software were used. The results showed that there was an increase in the diameter of the left ventricles in the male mice treated with Deposteron while in the female animals treated with Winstrol, there was a decrease in the left ventricular diameter in relation to the other two groups. Thus, one can conclude that the use of supraphysiological doses of the given AAS significantly alters the ventricular diameter in both male and female animals, which can cause a considerable change in both heart rate and blood pressure, and potentially induce disorders that are very relevant to the organism.

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“…Regarding the effects of exercise and chronic administration of nandrolone on BP, consistent with the present study, previous animal studies have reported ineffectiveness of endurance treadmill exercise ( 42 , 43 ) and chronic administration of nandrolone on BP ( 44 ). It was also reported that chronic administration of nandrolone and swimming exercise, alone or in combination, have no effect on BP ( 29 , 45 ). However, previous studies showed that in hypertensive mice, endurance exercise could significantly reduce BP ( 46 , 47 ).…”

Section: Discussionmentioning

confidence: 98%

Nandrolone plus moderate exercise increases the susceptibility to lethal arrhythmias

Baravati¹,

Joukar²,

Fathpour³

et al. 2015

Res Cardiovasc Med

View full text Add to dashboard Cite

Background:Until now, no experimental study has directly assessed the arrhythmogenesis of chronic consumption of anabolic androgenic steroids along with moderate-intensity endurance exercise.Objectives:We evaluated the influence of integration of anabolic androgenic steroids along with moderate-intensity endurance exercise on susceptibility to lethal ventricular arrhythmias in rat.Materials and Methods:The animal groups were as follows: control group (CTL); exercise group (EX) which were under 6 weeks of treadmill exercise; nandrolone group (Nan) which received 5 mg/kg of nandrolone decanoate twice a week; vehicle group (Arach) which received Arachis oil (solvent of nandrolone); trained vehicle group (Arach + Ex); and trained nandrolone group (Nan + Ex). One day after ending of the intervention period, arrhythmia was inducted by intravenous infusion of aconitine and ventricular arrhythmias were recorded. Then malondialdehyde (MDA) and glutathione peroxidase (GPX) of heart tissue were measured.Results:Nandrolone, exercise, and their combination were associated with heart hypertrophy. Exercise could prevent the incremental effect of nandrolone on MDA/GPX ratio. Chronic administration of nandrolone with moderate-intensity endurance exercise had no significant effect on blood pressure, heart rate, and basal electrocardiographic parameters. Combination of nandrolone and exercise significantly increased the incidence of ventricular fibrillation (VF) and reduced the VF latency (P < 0.05).Conclusions:The findings suggest that chronic coadministration of nandrolone with moderate-intensity endurance exercise facilitates the VF occurrence in rat. Complementary studies are needed to elucidate the involved mechanisms of this abnormality.

show abstract

Decanoato de nandrolona aumenta a parede ventricular esquerda, mas atenua o aumento da cavidade provocado pelo treinamento de natação em ratos

Cited by 10 publications

References 33 publications

Nandrolone plus moderate exercise increases the susceptibility to lethal arrhythmias

Nandrolone plus moderate exercise increases the susceptibility to lethal arrhythmias

Effects of Supraphysiological Doses of Anabolic Androgenic Steroids on the Left Ventricles of Male and Female Mice Submitted to Swimming

Nandrolone plus moderate exercise increases the susceptibility to lethal arrhythmias

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