Cardiac Dysfunction Induced by Low and High Diet Antioxidant Levels Comparing Selenium and Vitamin E in Rats

Turan, Belma; Hotomaroglu, Omer; Kiliç, Mesut; Demirel-Yılmaz, Emine

doi:10.1006/rtph.1998.1227

Cited by 25 publications

(10 citation statements)

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“…Turan et al showed that selenium can reduce ischemiareperfusion injury in the heart by increase GPX activity levels and reduce MDA [15,26]. The above-mentioned outcomes are consistent with results obtained in this study.…”

Section: Discussionsupporting

confidence: 82%

Effects of Selenium on Antioxidant Activity and Recovery From Sciatic Nerve Ischemia–Reperfusion in Adult Rats

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Delavari

Ahmadvand

et al. 2015

Zahedan J Res Med Sci

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Background: Selenium is an antioxidant trace element that is capable protects various tissues against damage induced by ischemiareperfusion injury. Objectives: This study examines the selenium effect on antioxidant activity and recovery from sciatic nerve ischemia-reperfusion in adult rats. Materials and Methods:In this experimental study, 80 adult male Wistar rats weighing 250 -300 g were used. They were divided into ten groups (n = 8 per group). The first group received sham surgery only. The second group received 0.2 mg/kg selenium without ischemiareperfusion surgery and eight remaining groups were divided to four control groups and four experimental groups which the latter groups received 0.2 mg/kg selenium. All ischemia groups were rendered in ischemic for 3 hours and reperfused for various times of 3, 7, 14 and 28 days. Half of the groups had experimental selenium (0.2 mg/kg) intraperitoneal injection treatment immediately after ischemia. According to a schedule for each group of rats bled and then centrifuged, and serum was prepared for assessment of activity levels of glutathione peroxidase (GPX), catalase (CAT), nitric oxide (NO), paraoxonase (POX), and malondialdehyde (MDA). Results: Comparison of the serum GPX, CAT, NO, POX, and MDA levels in the groups that received selenium with corresponding control group showed that selenium can increase plasma activity levels of GPX, POX and decrease activity levels of NO. Conclusions: Selenium with decreased activity levels of NO and increased activity GPX and POX can decrease ischemia-reperfusion injury in lower limb especially sciatic nerve.

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Section: Discussionsupporting

confidence: 82%

Effects of Selenium on Antioxidant Activity and Recovery From Sciatic Nerve Ischemia–Reperfusion in Adult Rats

Zendedel

Delavari

Ahmadvand

et al. 2015

Zahedan J Res Med Sci

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“…There is little information on the toxic effects of Se supplementation. In murines, a decrease in body weight and hair loss after several weeks of administration of Se concentrations above 10 ppm has been observed (Turan et al 1999;Tsunoda et al 2000). In all groups infected with T. cruzi, we observed the characteristic loss of body weight that is driven by TNFa (Truyens et al 1995), varying from 24% to 28% (a loss of 6-9 g/animal) between 7 and 21 dpi (data not shown).…”

Section: Resultsmentioning

confidence: 66%

Selenium supplementation at low doses contributes to the decrease in heart damage in experimental Trypanosoma cruzi infection

et al. 2003

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Chagasic patients with cardiomyopathy have low levels of selenium (Se), a fundamental trace element. We evaluated the effect of supplementing infected mice with Se (0.25-16 ppm). Supplementation with 0.25 or 1 ppm Se led to parasitaemia and survival curves similar to those of the control group. Mice treated with 4-16 ppm showed a dose-dependent decrease of parasitaemia, significant for the highest concentration. This was probably due to a direct effect on the parasites, which were lysed after in vitro incubation with Se. Survival rates did not change significantly; however, heart damage was reduced in infected mice supplemented with 4 ppm Se, as indicated by a lower cardiac isoform of creatine kinase levels. Our results imply that Se supplementation does not lead to a general protection during infection, but may help protect the heart from inflammatory damage. The effect of Se supplementation in the course of T. cruzi infection depends on the host-parasite pair employed.

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“…Several animal studies showed long time ago that Se deficiency may result in damage to the heart, liver, kidneys, lung and skeletal muscle [7, 29, 31, 32]. On the contrary, only recent investigations aimed to explore the effects of increased Se supplementation [13, 14, 29, 30], but none of them studied skeletal muscle functions.…”

Section: Discussionmentioning

confidence: 99%

Dietary selenium augments sarcoplasmic calcium release and mechanical performance in mice

et al. 2016

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BackgroundAs an essential trace element selenium plays a significant role in many physiological functions of the organs. It is found within muscles as selenocystein in selenoprotein N, which is involved in redox-modulated calcium homeostasis and in protection against oxidative stress.MethodsThe effects of two different selenium compounds (selenate and NanoSe in 0.5 and 5 ppm concentration for two weeks) on muscle properties of mice were examined by measuring in vivo muscle performance, in vitro force in soleus (SOL) and extensor digitorum longus (EDL) muscles and changes in intracellular Ca2+ concentration in single fibers from flexor digitorum brevis (FDB) muscle.. Western-blot analysis on muscle lysates of EDL and SOL were used to measure the selenoprotein N expression. Control mice received 0.3 ppm Se.ResultsWhile the grip force did not change, 5 ppm selenium diets significantly increased the speed of voluntary running and the daily distance covered. Both forms of selenium increased significantly the amplitude of single twitches in EDL and SOL muscle in a concentration dependent manner. Selenate increased fatigue resistance in SOL. The amplitude of the calcium transients evoked by KCl depolarization increased significantly from the control of 343 ± 44 nM to 671 ± 51 nM in the presence of 0.5 ppm selenate in FDB fibers. In parallel, the rate of calcium release during short depolarizations increased significantly from 28.4 ± 2.2 to 45.5 ± 3.8 and 52.1 ± 1.9 μM/ms in the presence of 0.5 ppm NanoSe and selenate, respectively. In 0.5 ppm concentration both selenium compounds increased significantly the selenoprotein N expression only in EDL muscle.ConclusionsSelenium supplementation augments calcium release from the sarcoplasmic reticulum thus improves skeletal muscle performance. These effects are accompanied by the increased selenoprotein N expression in the muscles which could result in increased oxidative stress tolerance in case of long lasting contraction.Electronic supplementary materialThe online version of this article (doi:10.1186/s12986-016-0134-6) contains supplementary material, which is available to authorized users.

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Cardiac Dysfunction Induced by Low and High Diet Antioxidant Levels Comparing Selenium and Vitamin E in Rats

Cited by 25 publications

References 0 publications

Effects of Selenium on Antioxidant Activity and Recovery From Sciatic Nerve Ischemia–Reperfusion in Adult Rats

Effects of Selenium on Antioxidant Activity and Recovery From Sciatic Nerve Ischemia–Reperfusion in Adult Rats

Selenium supplementation at low doses contributes to the decrease in heart damage in experimental Trypanosoma cruzi infection

Dietary selenium augments sarcoplasmic calcium release and mechanical performance in mice

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