Cardiac contractility after acute cooling of the organism and adaptogenic correction of its disorders

Афанасьев, С. А.; Alekseeva, E. D.; Bardamova, I. B.; Maslova, L.; Lishmanov, Yu. B.

doi:10.1007/bf00805144

Cited by 3 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The damage to cardiomyocyte sarcolemma was assessed from creatine phosphokinase (CPK) activity in perfusate using corn- Fig. 1. Increase in diastolic length of isolated rat heart by the 45th min of total ischemia (% of preischemic value).…”

Section: Methodsmentioning

confidence: 99%

“…Under real conditions cooling is usually combined with the influence of other stress factors which can potentiate its adverse effects. However, the effect of cooling in combination with other stress factors has not yet been studied.Our previous experiments showed that acute cooling of albino rats decreases myocardial contractility in vitro, while pretreatment with Rhodiola rosea extract (RRE) prevents these disturbances [1]. However, possible mechanisms of the cardioprotective effects of Rhodiola rosea detected by us under conditions of cold and psychoemotional stress and in acute myocardial ischemia [3] remain unclear.…”

mentioning

confidence: 98%

See 1 more Smart Citation

Effect ofRhodiola rosea on the resistance of isolated heart from stressed rats to ischemic and reperfusion damage

et al. 1997

Self Cite

View full text Add to dashboard Cite

Experiments on isolated hearts from rats pretreated with Rhodiola rosea and subjected to combined cooling and immobilization show that this adaptogen improves the resistance of the myocardium to ischemic and reperfusion damage and exerts a membrane-stabilizing effect.Key Words: cooling; creatine phosphokinase; contractility; isolated heart," Rhodiola roseaIn 1957, H. Selye pointed out the possibility of damag e to the heart induced by cold stress [7]. Moreover, it is well known that fall of outdoor temperature considerably increases the incidence of myocardial infarction [6,8]. Under real conditions cooling is usually combined with the influence of other stress factors which can potentiate its adverse effects. However, the effect of cooling in combination with other stress factors has not yet been studied.Our previous experiments showed that acute cooling of albino rats decreases myocardial contractility in vitro, while pretreatment with Rhodiola rosea extract (RRE) prevents these disturbances [1]. However, possible mechanisms of the cardioprotective effects of Rhodiola rosea detected by us under conditions of cold and psychoemotional stress and in acute myocardial ischemia [3] remain unclear.The aim of the present study was to evaluate the effect of the adaptogen RRE on the resistance of isolated heart from rats exposed to a combination of low temperature and immobilization to the damaging effect of total ischemia and reperfusion. Department of Experimental Cardiology, Institute of Cardiology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk MATERIALS AND METHODSExperiments were carried out on 36 Wistar male rats weighing 200-250 g. The rats were divided into 3 groups, 10-12 animals in each. Group l rats were stress-control. Group 2 rats were daily treated with adaptogen preparation RRE for 8 days in a dose of 1 ml/kg per os. Control group 3 comprised intact rats. A combination of acute cooling and immobilization was used as a model of stress: the rats were immobilized in supine position for 4 h at 5~Further experiments were carried out on rat hearts isolated by the Langendorff method [5]. The hearts were perfused with Krebs--Henseleit solution saturated with carbogen at 37~After a 15-min adaptation to perfusion [5], the hearts were subjected to a 45-rain total normothermal ischemia followed by a 60-rain repel-fusion. In all series, the contractile function of perfused heart was assessed in isotonic regime under a constant load of 5 g, and coronary flow was measured. The amplitude of contractions and changes in the heart diastolic length (contrac= ture) were calculated. Diastolic length was measured from the zero line 0.5 mm below diastolic fragment Of the contraction--relaxation curve. The damage to cardiomyocyte sarcolemma was assessed from creatine phosphokinase (CPK) activity in perfusate using corn-

show abstract

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 98%

Effect ofRhodiola rosea on the resistance of isolated heart from stressed rats to ischemic and reperfusion damage

et al. 1997

Self Cite

View full text Add to dashboard Cite

show abstract

“…Opposite changes in the content of homovanillic acid, aspartate, glutamate, and glycine in the examined structures were accompanied by inhibition of dopamine metabolism. Possible participation of cerebral glutamatergic system in the effect of TZ-146 is discussed.Key Words: dopamine; serotonin; neurotransmitter aminoacids; brain stem structures GABA-derivatives are in the focus of clinical and experimental studies due to a variety of their biological activities and, specifically, their cardioprotective potency [ 1,6]. The directed search for GABA-ergic agents with antiischemic activity yielded original cyclic GABA derivative TZ-146, which possesses antianginal [3] and antiarrhythmic [4] properties.…”

mentioning

confidence: 99%

Effect of cyclic GABA derivative TZ-146 on the content of neurotransmitters in rat brain stem

et al. 2000

View full text Add to dashboard Cite

The effect of cyclic GABA derivative TZ-146 on the content of catecholamines, serotonin, their metabolites, and neurotransmitter amino acids in rat hypothalamus and brain stem was studied by high-performance liquid chromatography with electrochemical detection. Opposite changes in the content of homovanillic acid, aspartate, glutamate, and glycine in the examined structures were accompanied by inhibition of dopamine metabolism. Possible participation of cerebral glutamatergic system in the effect of TZ-146 is discussed.

show abstract

Exploring New Applications for Rhodiola rosea: Can We Improve the Quality of Life of Patients with Short-Term Hypothyroidism Induced by Hormone Withdrawal?

Zubeldia¹,

Nabi

Río³

et al. 2010

Journal of Medicinal Food

View full text Add to dashboard Cite

Patients treated for differentiated thyroid cancer (DTC) are subjected to periodic surveillance that includes serum thyroglobulin measurements followed by radioiodine administrations for diagnostic and therapeutic purposes if necessary. Both procedures require adequately elevated blood levels of thyroid-stimulating hormone (TSH), which can be achieved by two approaches: parenteral administration of recombinant human TSH (rhTSH) or stopping thyroid hormone replacement until optimal levels of endogenous TSH are achieved. Although rhTSH administration does not require hormone withdrawal, it is not inexpensive and carries the risk of secondary effects. The latter option is simpler but induces a profound state of hypothyroidism, which results in physical and mental complaints that may interfere severely with the patient's activities of daily living. Rhodiola rosea is a popular plant in traditional medical systems in Eastern Europe and Asia with a reputation for stimulating the nervous system, decreasing depression, enhancing work performance, and eliminating fatigue, all features of clinical hypothyroidism. Investigators have also suggested additional benefits such as cardioprotection or even tumor growth inhibition. Here, we propose R. rosea as a viable alternative treatment for the symptoms of short-term hypothyroidism in patients with DTC who require hormone withdrawal.

show abstract

Cardiac contractility after acute cooling of the organism and adaptogenic correction of its disorders

Cited by 3 publications

References 4 publications

Effect ofRhodiola rosea on the resistance of isolated heart from stressed rats to ischemic and reperfusion damage

Effect ofRhodiola rosea on the resistance of isolated heart from stressed rats to ischemic and reperfusion damage

Effect of cyclic GABA derivative TZ-146 on the content of neurotransmitters in rat brain stem

Exploring New Applications for Rhodiola rosea: Can We Improve the Quality of Life of Patients with Short-Term Hypothyroidism Induced by Hormone Withdrawal?

Contact Info

Product

Resources

About