Cardiac complications in diphtheria and predictors of outcomes

Samdani, Sunil; Jain, Avani; Meena, Vinod; Meena, Chandra Bhan

doi:10.1016/j.ijporl.2017.10.032

Cited by 14 publications

(12 citation statements)

References 11 publications

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“…There was a lack of clinical trials or studies specifically investigating patients with BCM. The 15 studies included in this meta-analysis investigated patients with primary bacterial infection and clinical evidence of cardiac involvement, which included patients with bacterial myocarditis and/or cardiomyopathy [51,63,[125][126][127][128][129][130][131][132][133][134][135][136][137]. .…”

Section: Resultsmentioning

confidence: 99%

Bacterial cardiomyopathy: A review of clinical status and meta-analysis of diagnosis and clinical management

Albakri¹

2019

2516-7138

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Primary bacterial infection of the myocardium without associated endocarditis is a rare cause of cardiomyopathy (BCM). Staphylococcus aureus is the most common aetiological agent of BCM although infections with a broad range of other bacterial pathogens may also cause the disease. BCM is a major long-term sequela of myocarditis, which usually develops in the setting of overwhelming bacteraemia and sepsis. It has a wide spectrum of clinical manifestations ranging from a subclinical self-limiting flu-like illness to life-threatening arrhythmias, heart failure and even death. Its typical pathophysiological features include multifocal studding of the myocardium with tiny abscesses and the involvement of the left ventricle. The disease may lead to cardiac dysfunction, rhythm disturbances and myocardial rapture with or without secondary purulent pericarditis. Due to a very low incidence in modern clinical practice, there are no large-scale clinical trials on BCM. Almost all information about BCM originates from autopsy studies performed during the pre-antibiotic era with a few recent case reports and observational studies. The lack of clinical trials has undermined a specific understanding of BCM. This paper reviews published literature on aetiology, pathophysiology, diagnosis and clinical management of BCM as well as highlights implications for clinical practice and future research.

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Section: Resultsmentioning

confidence: 99%

Bacterial cardiomyopathy: A review of clinical status and meta-analysis of diagnosis and clinical management

Albakri¹

2019

2516-7138

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“…EKG berperan penting dalam menentukan keparahan penyakit, komplikasi dan prognosis. 18,19 Hasil pemeriksaan troponin pada pasien menunjukkan hasil yang meningkat yaitu 0,03, hal ini menunjukkan adanya kerusakan pada sel miokard.…”

Section: Pembahasanunclassified

<p>Manajemen perawatan pasien dengan manifestasi oral pasca difteri</p><p>Medical management of patient with post diphtheria oral manifestations</p>

Munthe

Dewi

2019

J Ked Gi Unpad

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Difteri kembali mewabah di Indonesia. Kementerian Kesehatan menetapkan status kejadian luar biasa dengan jumlah 907 kasus dari 29 provinsi hingga 25 Desember 2017. Jawa Barat merupakan provinsi dengan kasus difteri kedua terbanyak dengan jumlah 123 kasus dan jumlah kematian 13 kasus. Difteri merupakan penyakit infeksi akut disebabkan Corynebacterium diphtheriae menghasilkan eksotoksin penyebab kerusakan jaringan, pembentukan pseudomembran dan edema jalan nafas dapat berakhir pada kematian. Penurunan kondisi umum ini dapat menjadi faktor predisposisi mengubah Candida albicans komensal di rongga mulut menjadi patogen oportunistik sehingga mampu menyebabkan infeksi yang memperberat kondisi pasien. Tujuan laporan kasus ini untuk membahas manajemen perawatan multidisiplin ilmu pada pasien dengan manifestasi oral pasca difteri. Laporan kasus: Pasien laki-laki berusia 57 tahun dirujuk dari Departemen Ilmu Penyakit Dalam dengan diagnosis tonsilitis difteri disertai kandidiasis orofaringeal. Terdapat keluhan nyeri menelan, disertai timbulnya multipel ulser dan bercak putih pada mukosa oral, serta plak tebal putih kekuningan di posterior rongga mulut. Diagnosis ditegakkan sebagai lesi oral terkait difteri disertai kandidiasis orofaringeal. Sakit menelan menyebabkan pasien kekurangan asupan nutrisi. Medikasi yang diberikan meliputi nistatin oral suspensi, multivitamin, antiseptik klorheksidin glukonat 0,2%, serta diet cair tinggi kalori. Ulser mengalami penyembuhan, bercak putih menipis dan hilang dalam waktu 6 hari pemberian terapi. Manajemen perawatan lesi oral yang adekuat melalui terapi farmakologis, terapi penunjang dan edukasi yang komprehensif memiliki efikasi bagi pasien. Simpulan: Manajemen perawatan dengan manifestasi oral difteri berhasil dilakukan dengan melalui terapi farmakologis, terapi penunjang dan edukasi yang komprehensif. penekanan kebersihan mulut pasien, karena kebersihan gigi dan mulut dapat mencegah timbulnya infeksi oportunistik yang dapat memperparah keadaan rongga mulut.

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“…I noen helt få enkelttilfeller ble det under pågående behandling av pasienter med respirasjonsbesvaer registrert lav og uregelmessig hjertefrekvens som bedret seg etter injeksjon av adrenalin. Vi vet fra litteraturen at dødeligheten ved arytmi forårsaket av difteri er høy (10,11), og at arytmier som følge av myokarditt er en seneffekt av difteri. Samtidig er forbigående arytmi i akuttfasen beskrevet, riktignok takykardi (10).…”

Section: Langsom Hjerterytmeunclassified

Difteriutbrudd i en flyktningleir

Holen¹,

Rostrup²

2019

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Cardiac complications in diphtheria and predictors of outcomes

Cited by 14 publications

References 11 publications

Bacterial cardiomyopathy: A review of clinical status and meta-analysis of diagnosis and clinical management

Bacterial cardiomyopathy: A review of clinical status and meta-analysis of diagnosis and clinical management

<p>Manajemen perawatan pasien dengan manifestasi oral pasca difteri</p><p>Medical management of patient with post diphtheria oral manifestations</p>

Difteriutbrudd i en flyktningleir

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