Cardiac autonomic neuropathy in adult epilepsy patients in a tertiary hospital in South-Western Nigeria

Adebiyi, Adebayo; Komolafe, Morenikeji; Idowu, Akolade O; Omon, HenryE; Ogunniyi, Adesola

doi:10.4103/njcp.njcp_73_20

Cited by 3 publications

(2 citation statements)

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“…Autonomic dysfunction can manifest in individuals grappling with temporal lobe epilepsy or type 2 diabetes mellitus, even in the absence of neuropathy. Employing a 5-min assessment of HRV emerges as a pivotal technique for uncovering concealed cardiac autonomic neuropathy (CAN) [11,12]. The influence of seizures on the onset of cardiac autonomic neuropathy (CAN) has been implicated in instances of sudden unexpected death in epilepsy among those with the condition [5].…”

Section: Discussionmentioning

confidence: 99%

Cardiac Autonomic Dysfunction in Patients With Epilepsy

H.,

PANCHAKSHARIMATH,

2023

Int J Pharm Pharm Sci

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Objective: The objective of this research was to appraise autonomic impairment through the examination of both time-domain and frequency-domain parameters of heart rate variability in individuals with epilepsy. Methods: Thirty epilepsy patients and thirty healthy subjects were enrolled in our study for evaluation of autonomic functions, which was assessed by comparing heart rate variability between epilepsy patients and healthy subjects. Results: There was no notable disparity observed in mean heart rate between the two groups. However, the frequency-domain metrics-LF Power, HF Power, and LF/HF ratio exhibited statistically noteworthy differences when comparing the patients to the control group (p-value<0.05). Conversely, parameters such as SDNN, RMSST, and pNN50 did not demonstrate statistically considerable differences in comparison to the controls (p-value>0.05). The parameters did not exhibit statistically significant distinctions between individuals with epilepsy for under 10 y and those diagnosed with epilepsy for over 10 y. Conclusion: Our investigation revealed a notable contrast in HRV metrics between the patient group and the group of individuals in good health. The potential utilization of HRV as an indicator of susceptibility to SUDEP could enhance the quality of guidance provided to both patients and their families. Additional exploration is warranted, involving more extensive participant cohorts, and examining the impact of antiepileptic medications on HRV, within future studies.

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Section: Discussionmentioning

confidence: 99%

Cardiac Autonomic Dysfunction in Patients With Epilepsy

H.,

PANCHAKSHARIMATH,

2023

Int J Pharm Pharm Sci

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“…CAN is divided into three stages: deep breathing itself causes heart failure, the intermediate stage presents as a Valsalva reaction, and the severe stage presents as orthostatic hypotension. [4][5][6][7][8] Extensive research in recent years has shown that both the predialysis and dialysis stages of CKD are associated with increased cardiovascular risk and increased overall mortality. CKD is also associated with poor heart function.…”

Section: Introductionmentioning

confidence: 99%

Bellavere's scoring in chronic kidney disease: A study protocol

Toshniwal,

Kumar,

Acharya

2023

F1000Res

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Background: Chronic kidney disease (CKD) refers to abnormalities in kidney structure and/or function for more than three months; cardiac autonomic neuropathy (CAN) is an indicator of cardiovascular death due to various abnormalities such as cardiac arrhythmias. Heart rate variability (HRV) is an important component of CAN and has been shown to be related to CAN. This study aims to evaluate cardiac autonomic neuropathy at different stages of CKD with the Bellavere score and to correlate CAN with lipids, plasma, electrolytes and blood pressure in patients with CKD at different stages. Methods: Consent of 95 patients who met the diagnosis of chronic kidney disease according to Modification of Diet in Renal Disease (MDRD) criteria were included in the study. All subjects will have blood tests for lipids, anaemia, and electrolytes. All participants' blood pressure will be monitored. All subjects will also be scored based on the Bellevere scoring system, the Valsava ratio, and the 30:15 ratio. Data will be analyzed using SPSS version 21 and appropriate statistical tests will be used depending on the study objectives and the data collected. Expected results: Based on the literature review and previous studies, the results of this study should demonstrate the relationship between CAN and CKD at this stage. The study also expects to find higher Bellavere scores in patients with different stages of CKD.

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The High Prevalence of Cardiac Autonomic Neuropathy in Selected Epilepsy Patients May Depend on the Diagnostic Methods Used

Finsterer

2023

Nigerian Journal of Clinical Practice

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Cardiac autonomic neuropathy in adult epilepsy patients in a tertiary hospital in South-Western Nigeria

Cited by 3 publications

References 0 publications

Cardiac Autonomic Dysfunction in Patients With Epilepsy

Cardiac Autonomic Dysfunction in Patients With Epilepsy

Bellavere's scoring in chronic kidney disease: A study protocol

The High Prevalence of Cardiac Autonomic Neuropathy in Selected Epilepsy Patients May Depend on the Diagnostic Methods Used

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