Cardiac Arrest and Myocardial Infarction Induced by Postpartum Intravenous Ergonovine Administration

Tsui, Ban C. H.; Stewart, Barbara; Fitzmaurice, Aingeal; Williams, Russell B.

doi:10.1097/00000542-200102000-00033

Cited by 48 publications

(20 citation statements)

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“…While ergot derivatives are routinely administered after delivery or abortion in order to promote uterine contractions, cardiac complications related to this drug are rare (2)(3)(4)(5)(6)(7)(8). Including the present case, there were 9 reported cases of myocardial infarction after postpartum administration of ergot derivatives.…”

Section: Discussionmentioning

confidence: 71%

Postpartum Acute Myocardial Infarction Induced by Ergonovine Administration

et al. 2003

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Wereport a primigravida womanwith acute myocardial infarction caused by coronary artery spasm induced by intravenous administration of methyl ergometrine maleate just after delivery. Despite the frequent usage of ergot derivatives to promote uterine contractions, cardiac complications related to this drug are rare. Myocardial infarction may be overlooked in young womenin the early postpartum period. Careful monitoring and prompt evaluation should be performed whenthis drug is administered for obstetrical purposes. (Internal Medicine 42: 983-986, 2003)

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Section: Discussionmentioning

confidence: 71%

Postpartum Acute Myocardial Infarction Induced by Ergonovine Administration

et al. 2003

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“…Possible explanations for the finding of normal anatomy include the late performance of angiography or autopsy, healed coronary dissection, clot lysis and unrecognized coronary vasospasm. Methylergonovine has been used diagnostically to provoke coronary vasospasm, and several cases of acute myocardial infarction following postpartum methylergonovine administration have been reported (10)(11)(12)(13).…”

Section: Risk Factorsmentioning

confidence: 99%

Coronary artery disease and myocardial infarction in pregnancy: A review of epidemiology, diagnosis, and medical and surgical management

Kealey

2010

Canadian Journal of Cardiology

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“…A metilergonovina pode reduzir o diâmetro coronariano em 15%-20% após cateterização cardíaca. O derivado do ergot atua no receptor coronariano serotoninérgico 5-Ht 1D que inibe a NO-sintase e a liberação do NO, além de atuar sinergicamente com o tromboxano [76][77][78][79] . Além da contração uterina, pode ocorrer espasmo coronariano alguns minutos após uso venoso ou 20 minutos após injeção intramuscular, podendo evoluir para IAM e parada cardíaca em assistolia, particularmente em asiáticas grávidas [74][75][76] .…”

Section: Metilergonovina: Retrator Uterinounclassified

“…Methylergonovine may decrease coronary diameter 15-20 minutes after heart catheterization. The ergot byproduct acts in the serotoninergic coronary receptor 5-Ht 1D , which inhibits NO synthetase and NO release, in addition to synergistically act with thromboxane [76][77][78][79] . In addition to uterine contraction, there may be coronary spasm some minutes after intravenous injection or 20 minutes after muscular injection which may evolve to AMI and cardiac arrest in asystole, especially in Asian pregnant patients [74][75][76] .…”

Section: Anxiolytic Benzodiazepinesmentioning

confidence: 99%