Postpartum Acute Myocardial Infarction Induced by Ergonovine Administration

Hayashi, Yuji; Ibe, Toshio; Kawato, Hiroaki; Futamura, Noritaka; Koyabu, Sukenari; Ikeda, Uichi; Shimada, Kazuyuki

doi:10.2169/internalmedicine.42.983

Cited by 31 publications

(8 citation statements)

References 16 publications

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“…To the authors' knowledge, using bromocryptine for suppression of calcium in a few postpartum cases induced acute myocardial infarction (Hayashi et al 2003). However, these authors did not report that using bromocryptine for NMS had worsened the cardiac complications.…”

Section: Discussionmentioning

confidence: 89%

Zuclopenthixol-induced neuroleptic malignant syndrome presenting as fever of unknown origin, hyperglycaemia and acute myocardial infarction in a 60-year-old man

Varoğlu¹,

Ateş²,

Gündoğdu³

et al. 2009

The World Journal of Biological Psychiatry

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Neuroleptic malignant syndrome (NMS) is a rare clinical condition and potentially life-threatening complication of antipsychotic medications. We report a patient with an atypical presentation of NMS. A 60-year-old man with schizophrenia was admitted to our hospital with disturbed consciousness, fever and marked extrapyramidal rigidity both in the upper and lower extremities. He had been given i.m. zuclopenthixol 200 mg/month but had not taken the last dose. Laboratory investigations showed that creatinine phosphokinase 428 IU/l (normal up to 130), lactate dehydrogenase 772 IU/l (normal up to 450), blood glucose 256 mg/dl (65-110). Urine analyses revealed ketonuria. White blood cell (WBC) count was 6100 cells/mm(3). Therefore, the patient was diagnosed as having NMS and antipsychotic medications were stopped. Adequate hydration was provided and bromocryptine 5 mg was started three times a day. Despite treatment, the patient died due to acute myocardial infarction after 3 days of hospitalization.

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Section: Discussionmentioning

confidence: 89%

Zuclopenthixol-induced neuroleptic malignant syndrome presenting as fever of unknown origin, hyperglycaemia and acute myocardial infarction in a 60-year-old man

Varoğlu¹,

Ateş²,

Gündoğdu³

et al. 2009

The World Journal of Biological Psychiatry

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“…It is known that vasoconstrictive agents such as ergonovine, bromocriptine, and prostaglandin E2, which are frequently used during pregnancies, can induce coronary vasospasm [16–19]. The diagnosis of coronary vasospasm was presumed in most of the cases that were reported in literature, as signs of myocardial injury were noted on laboratory evaluation or by imaging with the presence of insignificant coronary artery disease.…”

Section: Discussionmentioning

confidence: 99%

Postpartum Coronary Vasospasm with Literature Review

Koneru

Cholankeril

Patel

et al. 2014

Case Reports in Cardiology

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“…9 These findings may be partially explained by the presence of occlusive transient coronary spasm due to increased renin release and angiotensin production during uterine hypoperfusion in the supine position 44 or secondary to vasoconstrictive agents used during pregnancies such as ergonovine. 45 Furthermore thrombus creation and solution with distal embolisation/fragmentation cannot be ruled out in some cases considered as NCA.…”

Section: Normal Coronary Arteriesmentioning

confidence: 99%

Acute Coronary Syndrome in Pre- and Post-partum Women – A Review

Aprigliano

Palloshi

Morici

et al. 2013

Interventional Cardiology Review

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Acute coronary syndrome (ACS) during pregnancy and the post-partum period are weighed by a high mortality rate for the mother and foetus. They should be considered as multifactorial diseases with a special role for sexual hormones. In this setting, ACS is mostly related to an early atherosclerotic disease, even if other conditions are responsible. Indeed, an important part is due to spontaneous coronary artery dissection, more common during delivery and the post-partum period. In the remaining situation, an isolated intracoronary thrombus or a normal angiographic pattern can be found at angiography. Pathophysiology is still uncertain with different hypothetical mechanisms. Prompt diagnosis of ACS and aetiology are essential for an optimal therapeutic strategy. Difficulties in treatment management is a matter for debate, especially in pre-partum women. In the last two decades improvements of diagnostic tools, coronary angiography and subsequent percutaneous treatment have changed the natural history of this rare condition.

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Postpartum Acute Myocardial Infarction Induced by Ergonovine Administration

Cited by 31 publications

References 16 publications

Zuclopenthixol-induced neuroleptic malignant syndrome presenting as fever of unknown origin, hyperglycaemia and acute myocardial infarction in a 60-year-old man

Zuclopenthixol-induced neuroleptic malignant syndrome presenting as fever of unknown origin, hyperglycaemia and acute myocardial infarction in a 60-year-old man

Postpartum Coronary Vasospasm with Literature Review

Acute Coronary Syndrome in Pre- and Post-partum Women – A Review

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