Cardiac abnormalities in cachectic patients before and during nutritional repletion

Heymsfield, Steven B.; Bethel, Robert A.; Ansley, Joseph D.; Gibbs, Daniel M.; Felner, Joel M.; Nutter, Donald O.

doi:10.1016/0002-8703(78)90300-9

Cited by 173 publications

(63 citation statements)

References 15 publications

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“…It has been reported (Ko and Paradise 1971; Blackburn et al 1977; Heymsfield et al 1978) that during a state of starvation that glucose is used as the primary energy source, then glycogen, and finally protein. When depletion energy and calories continue, protein is used as a source of glyconeogenic energy.…”

Section: Discussionmentioning

confidence: 99%

“…Others have reported (Ko and Paradise 1971;Heymsfield et al 1978;Kyger et al 1978) that myocardial can use a wide variety of substrates as an energy source and that it has the ability to shift preferential food substances in order to sustain its metabolic needs. Therefore, the heart can utilize not only glucose, lactate, pyruvate, glycogen and lipid, but during a state of starvation can also utilize endogenous substrates (glycogen and triglyceride) (Ko and Paradise 1971).…”

Section: Discussionmentioning

confidence: 99%

“…Several investigators (Pittman and Cohen 1964;Blackburn et al 1977; Heymsfield et al 1978; Kyger et al 1978; Abel et al 1979) have studied the effects of protein-calorie malnutrition (PCM) on cardiac structure, size and function in both man and the experimental animal. Heymsfield et al (1978) reported normal cardiac function in patients presenting with severe malnutrition, whereas Alleyne (1966) reported reduced cardiac output in both undernourshied adults and in children with Kwashiorkor.…”

mentioning

confidence: 99%

“…Heymsfield et al (1978) reported normal cardiac function in patients presenting with severe malnutrition, whereas Alleyne (1966) reported reduced cardiac output in both undernourshied adults and in children with Kwashiorkor. However, a consensus as to whether or not cardiac function is significantly depressed by PCM has not been reached.…”

mentioning

confidence: 99%

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Biochemical and hemodynamic changes in the hypertrophied dog heart subjected to chronic protein-calorie malnutrition.

Tabayashi

Iguchi

Arai

et al. 1987

Tohoku J. Exp. Med.

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Biochemical and hemodynamic changes were assessed in 13 dogs subjected to sub-coronary valvular aortic stenosis and chronic protein-calorie malnutrition (PCM). Red blood cell, hemoglobin, serum albumin, free fatty acids, blood glucose, cholinesterase and blood amino acid levels were measured. The dynamic geometry of the left ventricle (LV) was assessed with chronically implanted sonomicrometric piezoelectric crystals. Cardiac function was evaluated by mean velocity of circumferential fiber shortening (mean VcF) and the relationship between LV end-systolic pressure (LVESP) or LV wall stress (LVWst) and LV end-systolic diameter (LVESD). The following results were obtained : 1) A decrease in body weight and increases in free fatty acids and 3-Methylhistidine were observed following long-term PCM. 2) Mean VcF was not depressed in dogs subjected to PCM. 3) The relationship between LVESP or LVWst and LVESD shipted downward and to the right after PCM, indicating reduced myocardial contractility. These findings suggest that the left ventricle in hypertrophied dog hearts subjected to PCM retains normal pump function, despite a low state in the myocardium.protein-calorie malnutrition ; sub-coronary aortic stenosis ; free acid ; 3-Methylhistidine ; myocardial contractility

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Biochemical and hemodynamic changes in the hypertrophied dog heart subjected to chronic protein-calorie malnutrition.

Tabayashi

Iguchi

Arai

et al. 1987

Tohoku J. Exp. Med.

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“…A desnutrição hospitalar é um problema freqüente em cerca de 50% dos adultos hospitalizados 1,2 , com impacto sobre a morbimortalidade [3][4][5][6] , o tempo de permanência 1,3,7 e os custos hospitalares 7 . A nutrição enteral é a alternativa terapêutica que viabiliza a manutenção do estado nutricional em pacientes com impossibilidade parcial ou total de manter a via oral como rota de alimentação, devendo ser adotada como via de escolha, sempre que o trato gastrointestinal estiver funcionante 8 .…”

Section: N T R O D U ç ã Ounclassified

Suprimento de micronutrientes, adequação energética e progressão da dieta enteral em adultos hospitalizados

et al. 2008

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ObjetivoAvaliar a adequação da dieta enteral, em termos de micronutrientes e energia e identificar fatores interferentes na progressão da dieta enteral prescrita a adultos hospitalizados em um hospital geral de alta complexidade. MétodosEntre junho de 2004 e maio de 2005, adultos internados em um hospital de alta complexidade do sul do Brasil foram avaliados quanto às suas características clínicas e da prescrição da nutrição enteral. As características da nutrição enteral foram avaliadas e comparadas às recomendações diárias de ingestão, obtendo-se o percentual de adequação de nutrientes prescritos na dieta enteral em relação aos valores de recomendação para cada paciente. Os fatores associados à prescrição de energia foram identificados por meio de Regressão Linear Múltipla. ResultadosForam acompanhados 230 pacientes em uso de nutrição enteral. As recomendações diárias foram alcançadas satisfatoriamente para vitaminas hidrossolúveis (exceto ácido fólico), lipossolúveis (exceto vitamina D) e minerais (exceto cálcio). Em média, as prescrições iniciais de nutrição enteral ofereceram 24,0kcal/kg/dia (desvio-padrão=10,8, e valores mínimo e máximo de 4,3 a 69,2), e progrediram até 28,4kcal/kg/dia

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Weight Loss and the Heart

Schocken

Holloway²,

Powers³

1989

Arch Intern Med

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Cardiac abnormalities in cachectic patients before and during nutritional repletion

Cited by 173 publications

References 15 publications

Biochemical and hemodynamic changes in the hypertrophied dog heart subjected to chronic protein-calorie malnutrition.

Biochemical and hemodynamic changes in the hypertrophied dog heart subjected to chronic protein-calorie malnutrition.

Suprimento de micronutrientes, adequação energética e progressão da dieta enteral em adultos hospitalizados

Weight Loss and the Heart

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