Carcinosarcomes gynécologiques : revue générale et principes de prise en charge

Guy, Jean‐Baptiste; Trone, Jane‐Chloé; Casteillo, François; Forest, Fabien; Pacaut, Cécile; Moncharmont, Coralie; Espenel, Sophie; Vallard, Alexis; Escure, Julien Langrand; Collard, Olivier; Péoc’h, Michel; Magné, Nicolas

doi:10.1684/bdc.2014.1937

Cited by 7 publications

(7 citation statements)

References 29 publications

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Section: Discussionmentioning

confidence: 99%

“…The pathogenesis of carcinosarcoma is still unclear, and although the immediate effect of chemotherapy is more effective than in other ovarian cancers, the carcinosarcoma often quickly recurs with relatively poor prognosis, 40,41 and thus there is no clear consensus on treatment strategy. 42 As a result of this study, we have established a mouse model that can be used not only to better understand carcinosarcoma as a disease but also to study the signaling pathways and mechanisms regulated by K-ras and p53 in human ovarian cancer. As we develop more fundamental knowledge of relevant gene interactions and protein functions, we will undoubtedly improve the design of therapeutic inhibitors for the treatment of carcinosarcoma and optimize conditions for tests of novel preclinical anticancer drugs, prerequisites for more effective clinical diagnosis and/or treatment of human ovarian cancer in the future.…”

Section: Discussionmentioning

confidence: 99%

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KRAS mutation coupled with p53 loss is sufficient to induce ovarian carcinosarcomas in mice

Tang

Hsieh

Hsu

et al. 2017

Intl Journal of Cancer

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Ovarian carcinosarcoma cancer is the most lethal form of gynecological malignancy, but the pathogenesis and biological function for this ovarian cancer remain unknown. We establishment the transgenic mouse model of K-ras p53 and found that K-ras mutation and p53 deletion within the ovarian surface epithelium gave rise to ovarian lesions with a hyperproliferation and endometrioid glandular morphology. Furthermore, double mutant ovaries formed ovarian carcinosarcomas that were high grade and poorly differentiated. Induction was widely metastatic and spread to abdominal organs including liver, spleen, and kidney at 4 wk. We also confirmed the role of K-ras in ovarian cancer cell lines MCAS and PA-1 and showed that K-ras overexpression strongly induced cell proliferation, migration, and invasion. The ovarian cancer model we developed recapitulates the specific tumor histomorphology and the probable mechanism of malignant transformation in endometriosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

KRAS mutation coupled with p53 loss is sufficient to induce ovarian carcinosarcomas in mice

Tang

Hsieh

Hsu

et al. 2017

Intl Journal of Cancer

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“…Карциносаркома представляет собой редкую смешанную мезодермальную опухоль [17,18]. Характеризуется содержанием в своей структуре 2 компонентов: как саркомы, так и карциномы, причем элементы карциномы обычно железистые, тогда как саркоматозный компонент может быть любого гистологического типа (остеосаркома, хондросаркома, ЛМС и др.)…”

Section: обзорные статьиunclassified

“…[17]. Клинические проявления заключаются в формировании опухолевого полипа с эндо-или экзофитным ростом, сопровождающимся кровотечением [18]. Метастазирование в лимфатические узлы обычно характерно только для эпителиального (карциноматозного) компонента [19].…”

Section: обзорные статьиunclassified

Sarcomas of the lower female genital tract (vulva, vagina, and cervix): literature review and own cases

Сафронова

Artemyeva

Nyuganen

et al. 2019

Opuholi ženskoj reproduktivnoj sistemy

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“…Carcinosarcoma is a rare tumor that includes both carcinomatous and sarcomatous components [1, 2]. It occurs in the uterus most often and has been reported in lung and breast [1].…”

Section: Introductionmentioning

confidence: 99%

Carcinosarcoma of Vater’s papilla: case report of a rare neoplasm and review of the literature

et al. 2019

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BackgroundCarcinosarcoma is a rare tumor that includes both carcinoma and sarcoma components. It develops commonly in the female reproductive tract, most often in the uterus. However, as there are a small number of similar cases in the English literature, we would like to present a rare case of a carcinosarcoma in Vater’s papilla.Case presentationA 76-year-old female patient was preoperatively diagnosed with a papillary adenocarcinoma in Vater’s papilla by endoscopic biopsy. The patient underwent subtotal stomach-preserving pancreaticoduodenectomy, and postoperative pathological examination diagnosed the carcinosarcoma. The patient received adjuvant chemotherapy with gemcitabine, but multiple liver metastases were found 3 months after the operation. Though chemotherapy with gemcitabine and cisplatin was introduced, she died owing to tumor progression 7 months after the operation.ConclusionBecause carcinosarcoma of Vater’s papilla is a rare disease, a suitable treatment strategy has been unclear. We also present a review of the English literature regarding carcinosarcoma of Vater’s papilla.

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Carcinosarcomes gynécologiques : revue générale et principes de prise en charge

Cited by 7 publications

References 29 publications

KRAS mutation coupled with p53 loss is sufficient to induce ovarian carcinosarcomas in mice

KRAS mutation coupled with p53 loss is sufficient to induce ovarian carcinosarcomas in mice

Sarcomas of the lower female genital tract (vulva, vagina, and cervix): literature review and own cases

Carcinosarcoma of Vater’s papilla: case report of a rare neoplasm and review of the literature

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