Carcinosarcoma of the Prostate: A Case Report

Malignant Fibrous Histiocytoma of the Prostate in the Prostatic Urethra

“…Serum PSA concentrations at the time of the diagnosis of carcinosarcoma suggests that this assay is not valuable in early detection of tumor. Similar results have been reported for serum prostatic acid phosphatase (9,(11)(12)(13). The role of antiandrogen therapy and radiotherapy in the treatment of prostate carcinosarcoma is questionable (9).…”

The Impact of Radical Prostatectomy on the Survival of Patients with Carcinosarcoma of the Prostate

“…Serum PSA levels are usually lower than expected for the tumor volume [4]. Estrogen therapy may stimulate tumor growth, as suggested by the case reported by Hamlin and Lurid [16]. In contrast to adenocarcinoma of the prostate, carcinosarcoma is generally characterized by a rapid and lethal course [2,3].…”

“…The histogenesis of prostate carcinosarcoma is not completely understood, and various interpretations have been proposed for the heterogenous components of this tumor [11][12][13][14][15][16][17]. Some investigators suggested that these tumors develop as a result of undifferentiated, totipotential neoplastic cells that undergo multiple pathways of terminal differentiation into either mesenchymal or epithelial elements.…”

“…This theory is supported by the presence of epithelial markers (cytokeratin or EMA) in mesenchymal areas and the presence of ultrastructural features (desmosomes or tonofilaments) of epithelial differentiation in sarcomatoid elements [11]. Others believe that in cases where different components share no common features on immunohistochemical and electron microscopic examinations, carcinosarcomas might be the result of true "collision" tumors, where both malignant epithelial and mesenchymal components arise independently from each other [16]. Several investigators evaluated clonality in both malignant epithelial and mesenchymal elements using genetics or molecular techniques.…”

A case of prostatic carcinosarcoma with cytological and immunohistochemical findings

“…Morphologically, most of the prostate cancers are adenocarcinoma [1,2], although non-epithelial malignancies are known to develop in the prostate [3] with an incidence of less than 0.1% of all prostate malignancies [4]. Prostatic carcinosarcoma (PCS) which was first reported in 1967 by Hamlin and Lund [5], is an extremely rare malignancy and has very poor prognosis with a survival of approximate 7 months [6][7][8][9]. PCS is a histological mixture of adenocarcinoma and certain type(s) of sarcoma [1,2,10].…”