Carcinosarcoma of the oesophagus showing neuroendocrine, squamous and glandular differentiation

Robertson, N J; Rahamim, J; Smith, Mark E.

doi:10.1046/j.1365-2559.1997.2460852.x

Cited by 17 publications

(13 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In an earlier study [13] a minor endocrine component inside acinar cell carcinomas with positivity for chromogranin A has been described. Other mixed tumours were reported for the oesophagus with neuroendocrine, squamous and glandular differentiation [17]. Kamisawa et al [18] described and defined neuroendocrine differentiation in pancreatic duct carcinomas occurring in a scattered and a diffuse form.…”

Section: Discussionmentioning

confidence: 99%

Carcinoma of the Pancreas with Neuroendocrine Differentiation and Nodular Panniculitis

Berkovic¹,

Hallermann²

2003

Oncol Res Treat

View full text Add to dashboard Cite

Background: On rare occasions tumours of the pancreas produce high amounts of pancreatic lipase. The enzyme activity in the blood and in different tissues causes a syndrome called nodular panniculitis by focal necrosis of lipids and a concomittant inflammatory reaction. Case Report: A 72-year-old man was admitted to the dermatology clinic with the diagnosis of erythema nodosum. The patient had been well until 3 months earlier when painful red nodes developed on the skin of both shanks. He complained of profuse night sweating and a weight loss of 10 kg within that time but did not have fever. He also had noticed a painful swelling of his right index finger, left middle finger and the third toe on his left foot. Biopsy of the nodes revealed a focal necrosis of fatty tissue. Laboratory examinations showed a highly elevated concentration of serum pancreatic lipase. Further investigations showed a tumour in the pancreas and several osteolytic lesions. Tumour biopsy revealed a neuroendocrine carcinoma. After tumour resection serum lipase level immediately fell to almost normal values, and all skin and bone manifestations disappeared quickly. Conclusion: Due to its clinical appearance the panniculitis syndrome is most often mistaken for either erythema nodosum or rheumatoid arthritis. A resection of the tumour after correct diagnosis should always be considered because the widespread manifestations in the skin and bones do not represent distant metastasis and have a very good chance to dissolve completely.

show abstract

Section: Discussionmentioning

confidence: 99%

Carcinoma of the Pancreas with Neuroendocrine Differentiation and Nodular Panniculitis

Berkovic¹,

Hallermann²

2003

Oncol Res Treat

View full text Add to dashboard Cite

show abstract

“…described a case of carcinosarcoma of the gallbladder in which small cell carcinoma was associated with a minor chondrosarcomatous component . Similar cases of carcinosarcoma consisting of a combination of neuroendocrine carcinoma with a heterologous sarcomatous component have also been reported in other organs, such as the esophagus and stomach . However, it has been elucidated in recent years that neoplasms that had been referred to by the traditional terms ‘malignant mixed tumor’ or ‘carcinosarcoma’ are, in fact, epithelial neoplasms that feature apparently mesenchymal differentiation, and they should be more appropriately called ‘spindle cell carcinoma’, ‘sarcomatoid carcinoma’, or ‘metaplastic carcinoma’ .…”

Section: Discussionmentioning

confidence: 78%

Mixed adenoneuroendocrine carcinoma of the gallbladder with squamous cell carcinomatous and osteosarcomatous differentiation: Report of a case

Shintaku

Kataoka

Kono

2013

Pathology International

View full text Add to dashboard Cite

An extremely rare case of mixed adenoneuroendocrine carcinoma (MANEC) of the gallbladder is reported, in which the tumor showed diverse differentiation toward neuroendocrine tumor (grade 2), tubular adenocarcinoma, squamous cell carcinoma, and, in addition, osteosarcoma. The patient was an 80-year-old man, who underwent cholecystectomy because of a large polypoid tumor filling the gallbladder lumen. The tumor consisted of an intimate admixture of neuroendocrine tumor (grade 2) and tubular adenocarcinoma, and, in many areas, cell nests of neuroendocrine tumor appeared to bud off from tubular structures of the adenocarcinoma, in a manner resembling the 'ductulo-insular complex' seen in nesidioblastosis of the pancreas. Small areas of squamous cell carcinoma were also found. The stroma consisted of a dense proliferation of atypical spindle cells showing focal osteosarcomatous differentiation, and an apparent transition from an epithelial tissue component to atypical spindle cells was observed. Immunohistochemically, neuroendocrine cells were positive for synaptophysin, chromogranin A, and serotonin, and the sarcomatoid stroma was partly immunoreactive for cytokeratin. The present case is the first example of MANEC of the gallbladder with simultaneous squamous cell carcinomatous and osteosarcomatous differentiation. 'Neometaplasia' of carcinoma cells in diverse directions was considered the most plausible explanation for the formation of this multifaceted neoplasm.

show abstract

“…In the first scenario, the pathologist wishes to convey the concept that the tumor in question has the microscopic image of conventional squamous carcinoma, adenocarcinoma, or transitional cell carcinoma, but that additional studies have demonstrated the presence of submicroscopic neuroendocrine differentiation (19,20). One may alternatively see a truly mixed-pattern carcinoma at a light microscopic level, in which there is a juxtaposition or admixture of two distinct histologic patterns such as adenocarcinoma and small-cell neuroendocrine carcinoma (21)(22)(23)(24). It might be expected that the biological nature of such mixed lesions would also be a hybrid of the characteristics of each component in pure form, but validation of that premise and the definition of optimal therapies for these "amalgamated" tumors are still being studied.…”

Section: Other Aspects Of Pulmonary Neuroendocrine Neoplasiamentioning

confidence: 99%

Neuroendocrine neoplasms of the lung: Concepts and terminology

Wick

Marchevsky

2015

Seminars in Diagnostic Pathology

View full text Add to dashboard Cite

Carcinosarcoma of the oesophagus showing neuroendocrine, squamous and glandular differentiation

Abstract: We speculate that further tumour growth might have led to complete replacement of the tumour by pure squamous carcinoma, and that other advanced oesophageal squamous carcinomas might have had their origin in a short-lived carcinosarcomatous phase.

Cited by 17 publications

References 4 publications

Carcinoma of the Pancreas with Neuroendocrine Differentiation and Nodular Panniculitis

Carcinoma of the Pancreas with Neuroendocrine Differentiation and Nodular Panniculitis

Mixed adenoneuroendocrine carcinoma of the gallbladder with squamous cell carcinomatous and osteosarcomatous differentiation: Report of a case

Neuroendocrine neoplasms of the lung: Concepts and terminology

Contact Info

Product

Resources

About