Carcinosarcoma of the nasal cavity and paranasal sinuses

Shindo, Maisie L.; Stanley, Robert B.; Kiyabu, Milton

doi:10.1002/hed.2880120613

Cited by 48 publications

(44 citation statements)

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“…15,16 No major meta-analysis is done on the tumor studies as most literature are case reports and series where the authors widely vary clinical features, management techniques and biological outcomes. 9,17 Clinical behavior and treatment modalities are not stressed in these studies and more of a histopathology, differential diagnosis and tissues of origin were remarked. 18,19 Three landmark case series studies done in the past 3 decades have tried to emphasize on clinical features and treatment options of these tumors.…”

Section: Discussionmentioning

confidence: 99%

Sinonasal Teratocarcinosarcoma: A Rare Clinical Entity managed by Medial Maxillectomy and Adjuvant Chemoradiation

Gupta¹,

Naik²,

Lnu³

et al. 2012

An International Journal Clinical Rhinology

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Section: Discussionmentioning

confidence: 99%

Sinonasal Teratocarcinosarcoma: A Rare Clinical Entity managed by Medial Maxillectomy and Adjuvant Chemoradiation

Gupta¹,

Naik²,

Lnu³

et al. 2012

An International Journal Clinical Rhinology

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“…[15][16][17][18][19][20][21][22][23][24][25][26] We identified 5 cases of carcinosarcoma that originated in the maxillary sinus or ethmoid sinus with extension into the orbit. 15,16,19,23,26 These cases are summarized in Table 2. These patients were 45 to 86 years old, most were women (12/19), and most were Japanese (12/14).…”

Section: Discussionmentioning

confidence: 99%

Carcinosarcoma of the Orbit: Report of Two Cases and Review of the Literature

et al. 2008

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Objective-To report the clinicopathologic features of 2 patients with carcinosarcoma of the orbit. Design-Case reports.Participants-Two patients with orbital carcinosarcoma were identified. Methods-Retrospective chart review with clinicopathologic correlation and literature review.Main Outcome Measures-Clinical examination, imaging studies, and histopathologic findings.Results-Two patients, a 56-year-old woman and a 91-year-old woman, with orbital carcinosarcoma were identified. Both tumors contained sarcomatous and carcinomatous components and invaded periorbital structures.Conclusions-Carcinosarcoma may arise in the orbit or extend into the orbit from the paranasal sinuses. This malignant neoplasm should be aggressively treated with a combination of surgical resection, chemotherapy, and radiation therapy.Carcinosarcoma (true malignant mixed tumor) is a biphasic tumor consisting of intermixed malignant epithelial (carcinomatous) and mesenchymal (sarcomatous) components. Carcinosarcoma has been described to arise in many tissues, including the female genital tract, 1, 2 lung,3 kidney,4 bladder, 5 esophagus, 6 biliary tract, 7 and skin. 8 There are 3 reports of carcinosarcoma arising in the orbit 9-11 and an additional case of parotid gland carcinosarcoma that metastasized to the orbit. 12 Although this is a rare orbital tumor, ophthalmologists and pathologists should be aware of the clinicopathologic features for aggressive management. We report 2 patients with carcinosarcoma of the orbit and briefly review the literature. NIH Public Access Author ManuscriptOphthalmology. Author manuscript; available in PMC 2010 November 30. Case ReportsCase 1-A 56-year-old African-American woman with hypothyroidism, but otherwise healthy, was evaluated for a 3 to 4-month history of right epiphora and a tender right orbital mass. The best-corrected vision was 20/40 − in her right eye and 20/30 − in her left eye. Examination showed a firm, tender 1×1×1-cm nodule between the nasal bone and the right medial canthus (Fig 1). There was mild edema and ecchymosis overlying the mass. Her intraocular pressures were 22 mmHg in both eyes. There was a slight limitation of the right upgaze and 2 mm of right proptosis. The remainder of the ophthalmic examination results was normal. An otolaryngologic examination performed 1 week earlier showed on direct visualization a submucosal bulge anterior to the attachment of the middle turbinate consistent with the lacrimal sac area. CT showed a 2.3×2.0×2.9-cm mass arising from the right nasofrontal recess and eroding into the ethmoid sinus, medial orbital wall, and inner table of the right frontal sinus (Fig 2). A right medial orbitotomy was performed, and the tumor was found to be posterior to the globe and adherent to the periorbita and skin. An incisional biopsy was performed, and a frozen section of the biopsy was diagnosed as spindle cell neoplasm. After examination of permanent sections, the tumor was diagnosed as carcinosarcoma. The treatment plan was extensive surgery, including orbi...

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“…El estudio con inmunohistoquímica fue positivo para CD34 en el componente sarcomatoso, positivo para desmina en las células de aspecto rabdoide y positivo para citoqueratinas totales (AE1/AE3) en el componente epitelial maligno (Figura 3). sólo se encuentra un componente, recibe el nombre de carcinosarcoma 17 . En nuestro paciente, estuvieron presentes elementos epiteliales malignos, neurales, sarcomatosos, glandulares y blastomas, demostrados por el estudio inmunohistoquímico.…”

Section: Discussionunclassified

Teratocarcinosarcoma rinosinusal: Reporte de un caso

Íñiguez

Jiménez

et al. 2008

Rev. Otorrinolaringol. Cir. Cabeza Cuello

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RESUMENTeratocarcinosarcoma rinosinusal es una neoplasia maligna infrecuente y rara, que combina elementos de teratoma y carcinosarcoma. Se compone de epitelio benigno o maligno (fibroblastos), mesénquima (cartílago, hueso o músculo liso) y elementos neurales. Hasta el año 2008 se han reportado un total de 63 casos de ubicación rinosinusal.Presentamos el caso de un teratocarcinosarcoma de fosa nasal, en un hombre de 67 años de edad, que consultó por obstrucción nasal rápidamente progresiva. La lesión se resecó completamente por abordaje endoscópico. El diagnóstico fue confirmado por histopatología e inmunohistoquímica. Se realizó tratamiento complementario con radioterapia, sin evidencia de recidiva al año después de la cirugía.Palabras clave: Teratocarcinosarcoma, tumor rinosinusal. ABSTRACTRhinosinusal teratocarcinosarcoma is a rare malignant neoplasm, which combines teratoma and carcinoma elements. It is composed of benign or malignant epithelium (fibroblasts), mesenchymatic (cartilage, bone or smooth muscle) and neural elements. Until 2008, a total of 63 cases of rhinosinusal location have been reported.We present the case of a nasal cavity teratocarcinosarcoma in a 67 year old man that presented with rapidly progressing nasal obstruction. The lesion was completely resected by endoscopic approach. Diagnosis was confirmed by histological pathology and immunohistochemistry. Additional treatment by radiotherapy was administered, with no evidence of recurrences a year after surgery.

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Carcinosarcoma of the nasal cavity and paranasal sinuses

Cited by 48 publications

References 8 publications

Sinonasal Teratocarcinosarcoma: A Rare Clinical Entity managed by Medial Maxillectomy and Adjuvant Chemoradiation

Sinonasal Teratocarcinosarcoma: A Rare Clinical Entity managed by Medial Maxillectomy and Adjuvant Chemoradiation

Carcinosarcoma of the Orbit: Report of Two Cases and Review of the Literature

Teratocarcinosarcoma rinosinusal: Reporte de un caso

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