Carcinosarcoma of the Bladder

Schoborg, Thomas W.; Saffosx, Rosalie O.; Rodriquez, Angel; Scott, Charles L.

doi:10.1016/s0022-5347(17)55628-1

Cited by 25 publications

(8 citation statements)

References 3 publications

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“…74,79 Sarcomatoid carcinoma of the urinary bladder predominantly affects older adults and the elderly, with a predilection for male patients, and it has been reported in those with a history of radiation or cyclophosphamide therapy. 6,33,37,46,50,57,61 It tends to present at an advanced stage and is associated with a poor prognosis.Although pathologists have long recognized sarcomatoid carcinoma of the urinary bladder, 23,56 agreement on its proper classification and important findings clarifying its origins 4,12,63 are relatively recent developments. In this study, we discuss the classification terminology and clinical features of sarcomatoid carcinoma, and review its pathologic characteristics, including its morphology, immunohistochemical and ultrastructural profiles, and other entities from which it must be distinguished.…”

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Sarcomatoid Carcinoma of the Urinary Bladder

Liu

Zhang²,

Alexander³

et al. 2011

American Journal of Surgical Pathology

112

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Sarcomatoid carcinoma of the urinary bladder is an unusual malignancy composed of both carcinomatous and sarcomatous components. It is an aggressive tumor that presents at an advanced stage and confers a much poorer prognosis than conventional urothelial carcinoma. The proper nomenclature and histogenesis of these tumors have been subjects of debate for some time. There is an emerging consensus that sarcomatoid carcinoma is the most appropriate term for these neoplasms. The recent World Health Organization classification has applied this term to all tumors showing morphologic and/or immunologic evidence of both malignant epithelial and mesenchymal differentiation. Such tumors have been postulated to represent either multiclonal collision tumors or monoclonal cancers with divergent differentiation; recent molecular studies favor the latter theory. In this study, we discuss the nomenclature, clinical features, pathology, differential diagnosis, molecular genetics, and histogenesis of sarcomatoid carcinoma. We emphasize the importance of molecular genetic studies in providing insight into the histogenesis of this neoplasm. Sarcomatoid carcinoma seems to represent the final common pathway of urothelial carcinoma dedifferentiation.

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Sarcomatoid Carcinoma of the Urinary Bladder

Liu

Zhang²,

Alexander³

et al. 2011

American Journal of Surgical Pathology

112

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“…Approximately 25 cases of signet ring cell carcinoma have been described, while only about 9 cases of mesonephric adenocarcinoma have been documented so far. Adenocarcinoma can exist in a pure form or as part of a mixed tumour with other epithelial elements such as transitional or squamous or as part of a carcinosarcoma (Schoborg et al, 1980;Smith et al, 1983). It is the most common malignant tumour occurring in an exstrophied bladder (Abeshouse, 1943) and more frequently seen in schistosomiasis-infested bladders (Makar, 1962).…”

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Adenocarcinoma of the Bladder: Study of 14 Cases and Review of the Literature

Kamat

Kulkarni

Tongaonkar

1991

British Journal of Urology

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Fourteen patients with adenocarcinoma of the bladder have been seen over a 14-year period; 6 tumours were of urachal origin and the remaining 8 were primary. All tumours were muscle-infiltrating. The 6 patients with urachal tumours were subjected to surgery; 3 underwent partial cystectomy and 3 radical total cystectomy. All patients who underwent partial cystectomy are alive and free of disease at 60 months, 12 months and 12 months respectively. The other 3 patients who underwent radical cystectomy suffered recurrence and 2 succumbed to their disease within 1 year. All patients with primary adenocarcinoma of the bladder underwent radical cystectomy, 5 of them after planned pre-operative radiotherapy. There were 3 post-operative deaths. One patient died of an unrelated cause 30 months after surgery and 2 died of disseminated disease 8 and 16 months after surgery. One patient developed inguinal lymph node metastases 4 months after surgery and is controlled at 12 months with radiotherapy. Only 1 of the 8 patients with primary adenocarcinoma of the bladder is alive and free of disease at 6 months.

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“…To observe the clinical features of spindle and giant cell carci noma and related tumors, 28 cases, consisting of 25 cases reported after 1970 [Brinton et al, 1970;Fujita et al, 1972;Floltz et al, 1972;Delides, 1972;Ostroffet al, 1973;Patterson and Dale, 1976;Kato et al, 1977;Kishi et al, 1977;Johansen et al, 1979;Schoborg et al, 1980;Chasko et al, 1980;Ando et al, 1981;Duong et al, 1981;Uyama and Moriwaki, 1981] and our 3 cases, were summarized. The mean age was 61.5 years (27-82 years).…”

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confidence: 99%

“…The maleifemale ratio was 2.5 (20:8). 3 cases had histories of previous radiotherapy [Fujita et al, 1972;Schoborg et al, 1980] and 1 case had a history of prolonged administration of cyclophosphamide [Chasko et al, 1980]. These authors suggested the etiological significance of previous radiother apy or chemotherapy.…”

Section: Discussionmentioning

confidence: 99%