Carcinosarcoma of Breast Mimicking Breast Abscess

Muslim, Shahnawaz; Prasad, Geeta; Alam, Izhar; Singh, Shambhu Kumar; Nasrin, Nasrin

doi:10.1007/s13193-018-0777-z

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…The clinical symptoms of breast carcinosarcoma are similar to invasive ductal carcinoma, and include the presence of a large painful mass, nipple discharge, nipple depression, and skin ulceration (7,8,12,14). One study reported a case of carcinosarcoma presenting as a breast abscess (15). In the present case, the affected mammary gland showed the signs of local inflammation, including redness and swelling of the skin overlying the mass.…”

mentioning

confidence: 57%

Breast Carcinosarcoma: The Report of a Unique Case Including Fibrosarcoma and Metaplasia of Squamous Carcinoma with Adenocarcinoma; a Case Report and the Literature Review

Guo

Sun

Zhang

et al. 2019

Iran Red Crescent Med J

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Introduction: Breast carcinosarcoma is an extremely rare breast tumor comprising two distinct components, a carcinomatous component and a non-epithelial component of mesenchymal origin. It is a subtype of metaplastic carcinoma with a difficult preoperative diagnosis. Case Presentation: We present the case of a 68-year-old postmenopausal woman with squamous metaplasia coexisting with adenocarcinoma in the epithelial component of a breast carcinosarcoma. She has been admitted in

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mentioning

confidence: 57%

Breast Carcinosarcoma: The Report of a Unique Case Including Fibrosarcoma and Metaplasia of Squamous Carcinoma with Adenocarcinoma; a Case Report and the Literature Review

Guo

Sun

Zhang

et al. 2019

Iran Red Crescent Med J

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“…Due to the specific histologic feature, breast carcinosarcoma may have different biological characteristics when compared with IDC. Because of the rarity of breast carcinosarcoma, previous publications about this disease were a few small sample size retrospective analyses [ [8] , [9] , [10] , [11] , [12] , [13] , [14] ] and a few case reports [ [15] , [16] , [17] , [18] , [19] , [20] ]. From these limited studies, it appears that breast carcinosarcoma is always aggressive, poorly differentiated, and hormone receptor-negative [ 8 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological characteristics and survival outcomes in breast carcinosarcoma: A SEER population-based study

et al. 2020

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Objectives Carcinosarcoma of the breast is a rare disease. Its clinicopathological features and prognosis are not well defined. The aim of this study was to compare the clinicopathological features and clinical outcome between breast carcinosarcoma and breast invasive ductal carcinoma (IDC). Materials and methods Patients with breast carcinosarcoma and breast IDC were identified through the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2015. Then a comparison was conducted between these two groups. Propensity score matching (PSM) was performed to balance the effects of baseline clinicopathological differences. The Cox proportional hazard model was used to identify potential prognostic factors of breast carcinosarcoma. Results In total, we identified 63 patients with breast carcinosarcoma and 200,596 cases with breast IDC. Comparing with IDC, breast carcinosarcoma was significantly correlated with higher grading, higher staging, larger tumor size, lower lymph node involvement, and a higher proportion of triple negative breast cancer (TNBC), suggesting a significantly worse clinical outcome. After adjusting for the uneven clinicopathological variables with PSM, significant differences were still observed between these two histology types. Subgroup analysis further showed that carcinosarcoma-TNBC has an inferior clinical outcome compared with IDC-TNBC. Finally, we identified independent prognostic factors, namely, stage, tumor size, and distant metastasis. Conclusion It is concluded that breast carcinosarcoma has distinct clinicopathological features and a significantly worse clinical outcome than common IDC.

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Immunotherapy Combined with Chemotherapy in Relapse Metaplastic Breast Cancer

Chen,

Meng,

Zhou

et al. 2023

OTT

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Metaplastic breast cancer (MBC) is a rare disease, and there was rarely reported the treatment after recurrence and metastasis. Here, we report the treatment of an adult patient who suffered from MBC with lung, lymph nodes and left pleura metastasis after radical surgery. The next-generation sequencing result demonstrated that it had tumor mutational burden (TMB) of 12.0 Muts/Mb and microsatellite stability. The patient received sintilimab, an immune checkpoint inhibitor, plus chemotherapy and achieved partial response (PR). This is a report of a good outcome of metastatic MBC achieving 24 months of progression-free survival (PFS) and 39 months of overall survival (OS) with a combination therapy of immune checkpoint inhibitor and chemotherapy. Immunochemotherapy may have antitumor activity for relapse MBC. TMB may serve as a potential predictor associated with PD-1 inhibitors in MBC and help clinicians make an optimum treatment strategy.

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Carcinosarcoma of Breast Mimicking Breast Abscess

Cited by 3 publications

References 10 publications

Breast Carcinosarcoma: The Report of a Unique Case Including Fibrosarcoma and Metaplasia of Squamous Carcinoma with Adenocarcinoma; a Case Report and the Literature Review

Breast Carcinosarcoma: The Report of a Unique Case Including Fibrosarcoma and Metaplasia of Squamous Carcinoma with Adenocarcinoma; a Case Report and the Literature Review

Clinicopathological characteristics and survival outcomes in breast carcinosarcoma: A SEER population-based study

Immunotherapy Combined with Chemotherapy in Relapse Metaplastic Breast Cancer

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