Carcinome épidermoïde primitif du sein. À propos de 3 cas

Kebdani, Tayeb; Saadi, Ikram; Kharmash, M; Hadadi, Khalid; Omari-Alaoui, H El; Ghazi, E. El; Mansouri, Abdellah; Errihani, Hassan; Benjaafar, Noureddine; Gueddari, B.K. El

doi:10.1016/s1278-3218(02)00258-5

Cited by 19 publications

(16 citation statements)

References 8 publications

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“…Most patients present with a well circumscribed palpable mass, with a median size of 3 -4 cm. In some reports more than half of these tumors measure over 5cm, with some massive lesions (> 20cm) which may displace the nipple and ulcerate through the skin [1][2][3][4][5][6][7][8][9][10]. Like our patients, the tumor occurs very rarely as breast abscess.…”

Section: Discussionmentioning

confidence: 49%

“…In our experience, it accounts for more than 0.5% of all invasive breast cancer and 68% of all metaplastic carcinoma. In PPSCC, all or the majority of the cells, are squamous type with keratinization, and the presence of some glandular features should make us disregard this diagnosis [1][2][3][4][5][6][7][8][9]. These criteria are critical to distinguish true squamous breast cancers from the common ductal carcinoma not otherwise specified with squamous metaplasia.…”

Section: Discussionmentioning

confidence: 99%

“…The prognosis is still a subject of controversy; some reports suggest that it is aggressive, with an outcome comparable to poorly differentiated ductal carcinoma of the breast [1,5,7,9]. Large tumor size and positive lymph node status were found to be the principle features of poor prognosis [1].…”

Section: Discussionmentioning

confidence: 99%

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Pure Primary Squamous Cell Carcinomas of the Breast: A Report of Eight Cases

Znati

2010

J Med Cases

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Pure primary squamous cell carcinoma (PPSCC) of the breast is a rare neoplasm included in World Health Organization Classification of tumors (2003) in metaplastic breast cancer. It accounts for less than 0.1% of all breast carcinomas. We performed a retrospective review of all women diagnosed or treated as PPSCC, from January 2004 to June 2009 to assess clinical presentation, surgical and pathological findings, treatment and outcome. Eight patients were identified. The median age was 48.2 (range: 40 -57) years. The average tumor size was 7.3 cm, with a range of 3.5 to 18 cm. There were one well differentiated, three moderately differentiated and four poorly differentiated PPSCC. Two cases were stage IIA, two cases stage IIIA and three cases stage IIIB. Primary treatment was mastectomy in six patients and large local excision in one patient. There was lymph node (LN) involvement in one patient. Estrogen and progesterone receptors status and over expression of HER 2 were assessed and none tumors was positive. Cytokeratin 5/6 and/ or Cytokeratin 14 were positive in all tumors. All patients were treated by radiotherapy and chemotherapy. Though PPSCC of the breast is a very rare and aggressive disease, in our experience it's relatively frequent. Strict histologic criteria should be used to diagnose PPSCC, because they have significantly lower axillary lymph node metastasis, lower estrogen and PR positivity, and they are often treatment-refractory. The role of different new chemotherapy regimens needs to be explored.

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Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 99%

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Pure Primary Squamous Cell Carcinomas of the Breast: A Report of Eight Cases

Znati

2010

J Med Cases

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“…Clinical and radiologic appearances are not specific, and tumors are usually hormone receptor negative [3][4]. The prognosis for this type of breast cancer is still a subject of controversy: some reports suggest that it is aggressive, with an outcome comparable to that of poorly differentiated breast adenocarcinoma [2][3][4][5][6][7]. PSCCB express some markers associated with basal cancers-epidermal growth factor receptor (EGFR), cytokeratin-5 (CK5), and cytokeratin-6 (CK6), however, their clinical features suggest that they represent a unique subtype.…”

Section: Introductionmentioning

confidence: 99%

“…PSCCB express some markers associated with basal cancers-epidermal growth factor receptor (EGFR), cytokeratin-5 (CK5), and cytokeratin-6 (CK6), however, their clinical features suggest that they represent a unique subtype. As a result of lack of data, the issue of whether to prescribe neoadjuvant or adjuvant treatment and what type of therapy for PSCCB remains unresolved [7].…”

Section: Introductionmentioning

confidence: 99%

Primary Squamous Cell Carcinoma of the Breast is a Rare and Special Entity

Mahrous

Mohamed²,

Sisi³

et al. 2018

J. Anal. Oncol.

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Background: Primary squamous cell carcinoma of the breast (PSCCB) is a very rare malignancy of the breast. Pure squamous cell carcinoma of the breast can originate from skin adnexa, the nipple or the epithelium of deep-seated epidermoid cyst or squamous metaplasia on chronic inflammation background. Case Report: Our case is a 49-year-old female patient who presented with a highly suspicious lump in her left breast. Bilateral mammography and core biopsy were carried out. The core biopsy was revealed atypical cells and review inconclusive. Incisional biopsy was done and revealed squamous cell carcinoma of the breast (SCCB). Her metastatic work up at presentation was unremarkable. Left-side modified radical mastectomy was carried out. TNM staging was Stage IIa pT2N0M0 GIII, Estrogen receptors (ER) and Progesterone receptors were negative and HER2/Neu was negative as well (Triple negative). Pt had adjuvant chemotherapy and radiotherapy. Eight months later, she developed multiple brain metastasis as solitary site of metastasis, then after four months she developed hepatic and pulmonary deposits. Pt survived only 25 months since disease diagnosis. We report this case with relatively younger age to confirm that primary squamous cell carcinoma of the breast has special aggressive entity and this conjugant with few series. The treatment of primary SqCC of the breast does not differ from other common histological types of breast cancer so far. Conclusions: The prognosis of this disease is highly uncertain and the treatment options are unclear and controversial. There is inadequate literature and treatment guidelines. To our knowledge it is the first case to be reported from arab region with aggressive behavior and short survival period.

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