Carcinome endométrioïde in situ et primitif de la trompe développé sur une endométriose tubo-ovarienne. À propos d'une observation

Bouraoui, Saâdia; Goucha, Aïda; Ouertani, L; Mekni, Amina; Bellil, Selma; Mahjoub, S.; Zouari, F.; Kchir, Nidhameddine; Haouet, Slim

doi:10.1016/s1297-9589(02)00004-8

Cited by 7 publications

(1 citation statement)

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“…As far as the pathological diagnosis is concerned, the transition zone between benign and malignant endometriosis is detectable in only 36-42% of cases, and coexistence of a neoplasm and endometriotic tissue is sufficient to demonstrate the endometriotic origin of the lesion (Figure 1) (36,37). Extra-ovarian malignancies can involve the colon and recto-vaginal septum, and more rarely, the small bowel, vulva, vagina, fallopian tube, urinary tract, pleura and pelvic lymph nodes, thus paralleling the distribution of benign extra-ovarian endometriosis (5,25,35,36,(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49). Scar endometriosis, i.e.…”

Section: Malignant Extraovarian Endometriosismentioning

confidence: 99%

Endometriosis-associated Extraovarian Malignancies: A Challenging Question for the Clinician and the Pathologist

Gadducci

Zannoni

2020

Anticancer Res

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Endometriosis is an estrogen-dependent disease, which affects 10% of women in the reproductive age. Malignant transformation is an uncommon event, which affects approximately 0.7-2.5% of women, and, when it occurs, it involves ovarian and extraovarian sites in 75% and 25% of the cases, respectively. Endometriosis correlates with presentation of clear cell and endometrioid carcinoma of the ovary. Activation of phosphatidylinositol 3-kinase (PIK3) -protein kinase B (AKT) -mammalian target of rapamycin (mTOR) pathway, aberrant chromatin remodeling due to AT-rich interactive domain-containing protein 1A (ARID1A) mutation and inactivation of estrogen receptor-α signaling seem to play a major role in the carcinogenesis.To date, little data are available regarding endometriosisassociated extraovarian malignancies. The aim of the present study was to review the clinical, pathological and prognostic features of endometriosis-related neoplasms arising from extraovarian sites, with particular focus on intestinal malignancies, urinary tract malignancies and tumors arising from surgical scars.

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