Carcinoma of the tonsillar region

Mizono, Gary S.; Diaz, Richard; Fu, Karen K.; Boles, Roger

doi:10.1288/00005537-198603000-00002

Cited by 35 publications

(16 citation statements)

References 23 publications

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“…Similar results have been described by Fayos and Lampe: Mantravadi et a1., 22 Nussbaum et al, 23 Wang,' and Mizono et a1. 24 Million and Cassisi: Mendenhall et a1.,l6 Perez et al, 25 and Shukovsky and Fletcherlg have indicated that doses of 6,000 to 6,500 cGy are adequate to control T1 lesions and 7,000 cGy is s a c i e n t for most T2 tumors delivered with 180 to 200 cGy per day in 5 weekly fractions. However, biologic doses significantly greater than 7,000 cGy are necessgry to achieve satisfactory tumor control in T3-T4 tumors or N3 cervical lymph nodes.…”

Section: Carcinoma Of the Tonsil Has Been Primarily Treated With Irramentioning

confidence: 99%

Carcinoma of the tonsillar fossa: A nonrandomized comparison of irradiation alone or combined with surgery: Long‐term results

et al. 1991

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The results of therapy are reported in 296 patients with histologically proven epidermoid carcinoma of the tonsillar fossa; 127 were treated with irradiation alone (5,500 to 7,000 cGy), 133 with preoperative radiotherapy (2,000 to 3,000 cGy) or were initially planned for preoperative irradiation but treated with radiotherapy alone, and 36 with postoperative irradiation (5,000 to 6,000 cGy). The operation in all but 4 patients consisted of an en bloc radical tonsillectomy with ipsilateral lymph node dissection. Actuarial 5-year no evidence of disease (NED) was as follows: survival rates for patients with T1 tumors, 76%; T2, 54%; T3, 45%; and T4, 20%. Patients with no cervical lymphadenopathy or with a small metastatic lymph node (N1) had better relapse-free survival (60% to 70% at 5 years) than those with large or fixed lymph nodes (30% to 40%). Primary tumor recurrence rate in the T1-T2 groups was about 20% in patients treated with irradiation and surgery and 30% for those treated with irradiation alone (difference not statistically significant), 30% in patients with stage T3 lesions in all treatment groups, and 33% in patients with T4 disease treated with surgery and postoperative irradiation compared to 52% with irradiation alone (p = 0.03). The overall recurrence rate in the neck was about 20% for the N0 patients, 25% for N1, and 30% for those with N2 and N3 cervical lymph nodes in the 4 treatment groups. The incidence of contralateral neck recurrences was about 8% with the various treatment modalities.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Carcinoma Of the Tonsil Has Been Primarily Treated With Irramentioning

confidence: 99%

Carcinoma of the tonsillar fossa: A nonrandomized comparison of irradiation alone or combined with surgery: Long‐term results

et al. 1991

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“…Oropharyngeal cancer is a common head and neck cancer and, in particular, tonsillar cancer has increased recently. More than half of the patients with tonsillar cancer present with typically lymphatic metastasis (stage III or IV) and the prognosis is commonly predicted using the T classification (tumor size) and N classification (lymph node status) . To our knowledge, no report in the English‐language literature has assessed the prognostic significance of lymph node density in predicting the risks of disease recurrence and survival in patients with oropharyngeal cancer, especially in patients with tonsillar cancer separately.…”

Section: Introductionmentioning

confidence: 99%

“…More than half of the patients with tonsillar cancer present with typically lymphatic metastasis (stage III or IV) and the prognosis is commonly predicted using the T classification (tumor size) and N classification (lymph node status). 15,16 To our knowledge, no report in the English-language literature has assessed the prognostic significance of lymph node density in predicting the risks of disease recurrence and survival in patients with oropharyngeal cancer, especially in patients with tonsillar cancer separately. We designed this study to assess the value of lymph node density in predicting survival after surgery for patients with tonsillar cancer and positive neck nodes.…”

Section: Introductionmentioning

confidence: 99%

Lymph node density as an independent prognostic factor in node‐positive patients with tonsillar cancer

et al. 2015

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“…[1][2][3][4][5][6][7][8] There are no dedicated randomized trials that have focused on comparing radiotherapy versus surgery for oropharyngeal carcinoma. Radiotherapy is preferred at many centers because of presumed lower morbidity and better functional and cosmetic outcome compared with surgical treatment, particularly with the increased use of chemoradiation.…”

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confidence: 99%

Intensity‐modulated chemoradiation for treatment of stage III and IV oropharyngeal carcinoma

Huang

Xia

Chuang

et al. 2008

Cancer

125

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BACKGROUND.Treatment outcomes for stage III and IV oropharyngeal carcinoma treated with intensity‐modulated radiotherapy (IMRT) and concurrent chemotherapy without prior surgical resection were reviewed.METHODS.Between April 2000 and September 2004, 71 patients underwent IMRT concurrent with chemotherapy without prior surgical resection for stage III and IV oropharyngeal carcinoma. Chemotherapy was platinum based. The gross tumor volume (GTV) received 70 Gy in 2.12 Gy per fraction. The high‐risk clinical tumor volume (CTV) received 59.4 Gy in 1.80 Gy per fraction, and the low‐risk CTV received 54 Gy in 1.64 Gy per fraction.RESULTS.With a median follow‐up of 33 months, the 3‐year local, regional, and locoregional progression‐free probabilities were 94%, 94%, and 90%, respectively. The 3‐year overall survival estimate was 83%. Locoregional failures occurred in the GTV in 7 patients. Acute grade 3 or 4 toxicity developed in 35 patients. A feeding gastrostomy was placed in 25 patients. Late xerostomia was grade 0 in 16 patients, grade 1 in 31 patients, and grade 2 in 24 patients at last follow‐up. No patients experienced grade 3 or 4 late toxicity, except for 1 who developed osteoradionecrosis of the mandible.CONCLUSIONS.Excellent local and regional control was achieved with IMRT and concurrent chemotherapy without prior surgical resection in the treatment of stage III and IV oropharyngeal carcinoma. Significant sparing of the parotid glands and other critical normal tissues was possible using IMRT with moderate acute toxicities and minimal severe late effects. Cancer 2008. © 2008 American Cancer Society.

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Carcinoma of the tonsillar region

Cited by 35 publications

References 23 publications

Carcinoma of the tonsillar fossa: A nonrandomized comparison of irradiation alone or combined with surgery: Long‐term results

Carcinoma of the tonsillar fossa: A nonrandomized comparison of irradiation alone or combined with surgery: Long‐term results

Lymph node density as an independent prognostic factor in node‐positive patients with tonsillar cancer

Intensity‐modulated chemoradiation for treatment of stage III and IV oropharyngeal carcinoma

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