Carcinoma of the tongue: A case series analysis of clinical presentation, risk factors, staging, and outcome

Gorsky, Meir; Epstein, Joel B.; Oakley, C. Elizabeth; Le, Nhu D.; Hay, John; Stevenson‐Moore, Peter

doi:10.1016/j.tripleo.2003.12.041

Cited by 130 publications

(102 citation statements)

References 28 publications

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“…No randomised controlled trials have yet been performed to compare the effectiveness of surgery with chemoradiation, and the usefulness of chemoradiation therapy involving systemic chemotherapy thus remains to be clarified. After surgery, the 5-year survival rate ranged from 27 to 60% of stage III patients, while it ranged from approximately 12 to 40% of stage IV patients (Chen et al, 1999;Sessions et al, 2002;Greenberg et al, 2003;Lo et al, 2003;Gorsky et al, 2004;Liao et al, 2006;Fan et al, 2007); our results were therefore similar to the results after surgery. In particular, the results of arterial injection therapy by cisplatin with sodium thiosulphate were excellent.…”

Section: Discussionsupporting

confidence: 80%

Intra-arterial chemoradiotherapy for locally advanced oral cavity cancer: analysis of therapeutic results in134 cases

et al. 2008

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The objective of this study was to investigate the therapeutic results of arterial injection therapy via the superficial temporal artery for 134 cases of stages III and IV (M0) oral cavity cancer retrospectively, and to clarify the prognostic factors. We administered intraarterial chemoradiotherapy by continuous infusion of carboplatin in 65 cases from January 1993 to July 2002. Systemic chemotherapy was performed on 26 cases at the same time. We administered intra-arterial chemoradiotherapy by cisplatin with sodium thiosulphate in 69 cases from October 2002 to December 2006. Systemic chemotherapy was performed on 48 cases at the same time. The 3-year local control rate was 68.6% (T2-3: 77.9%; T4: 51.3%), and the 3-year survival rate was 53.9% (stage III: 62.9%; stage IV: 45.3%). Regarding the results of multivariate analysis of survival rates, age (o65), selective intra-arterial infusion, and the use of cisplatin as an agent for intra-arterial infusion were significant factors. The therapeutic results of intra-arterial chemoradiotherapy via the superficial temporal artery were not inferior to the results of surgery. In particular, the results of arterial injection therapy by cisplatin with sodium thiosulphate were excellent, so we believe that it will be a new therapy for advanced oral cavity cancer.

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Section: Discussionsupporting

confidence: 80%

Intra-arterial chemoradiotherapy for locally advanced oral cavity cancer: analysis of therapeutic results in134 cases

et al. 2008

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“…Recent studies conducted on patients under the age of 40 have shown an increased incidence of oral cavity and tongue cancers (4). In line with the literature, male patients in their fifth and sixth decades formed the majority in our study as well.…”

Section: Discussionsupporting

confidence: 90%

The Effect of Correlation Between Prognostic Factors and Long-Term Mortality in Tongue Cancers

Kubat¹,

Beton²,

Gerçeker³

2016

Istanbul Med J

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The incidence of head and neck cancer is increasing in many parts of the world. Oral cavity cancer comprises approximately 3% of all types of cancer, and tongue cancer is the most common type of oral cavity cancer (1). Because a reliable epidemiological study has not yet been conducted, it is not possible to give a clear description of this subject in our country. Although head and neck cancer is usually diagnosed in the sixth decade of the patient's life, the prevalence among young patients (younger than 40 years) is increasing (2). Tongue cancer is more common in men; however, due to an increase in tobacco use, some studies have reported that the incidence of tongue cancer has increased among women as well.90% of the etiological factors of tongue cancer are associated with cigarettes, cigars, pipes, tobacco use, passive smoking, and alcohol consumption. Human papilloma virus (HPV) is also an infectious agent whose carcinogenic effects have been well proven (3). Other etiological factors are suppression of the immune system due to human immunodeficiency virus (HIV), long-term trauma secondary to the long-term use of inappropriate dentures, and poor oral hygiene.Squamous cell carcinoma (SCC) represents over 90% of oral cavity and tongue cancer cases (4). Premalignant lesions are classified as leukoplakia, erythroplakia, oral submucosal fibrosis, and oral lichen planus; studies conducted on this subject state that 6.6%-36.4% of premalignant lesions progress to invasive carcinoma within 1.5-8.5 years. Compared to leukoplakia, erythroplakia has a higher risk of malignancy (5).The tumor stage, histopathologic stage, growth pattern, lymph nodes in the neck and distant metastasis, and classification of the tumor as secondary or primary are important factors in determining the prognosis and survival in neck cancer cases. In cases of squamous cell carcinoma of the tongue, lymph node metastasis in the neck is quite common, and patients clinically diagnosed with non-metastatic lymph nodes in the neck (N0) have a high rate of occult metastasis.After histopathological diagnosis, for staging, computed tomography (CT) and/or magnetic resonance imaging (MRI) should be performed. Positron emission tomography (PET) is used in the determination of distant metastases in advanced stage disease (6).The choice of treatment varies depending on the status of the primary tumor and locoregional lymph node involvement. Surgery and radiotherapy (RT) can be applied as primary treatments The Effect of Correlation Between Prognostic Factors and Long-Term Mortality in Tongue CancersObjective: The aim of this study was to review demographic data, prognostic factors, and the effect on mortality of patients who were treated for tongue cancer and followed up at our clinic.Methods: Data between 2000 and 2013 were retrospectively reviewed. This report includes data from 96 patients. Demographic data, dental prostheses, smoking and drinking habits, CVs, tumor characteristics, treatment methods, recurrence, distant metastasis, second primary tumor pre...

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“…La supervivencia global a 5 años del cáncer de lengua es del 40%-50% según los diferentes estudios 13,33,34 . En el estudio realizado por Yip y cols 13 la supervivencia global a 5 años del cán-cer de lengua fue del 46%.…”

Section: Discussionunclassified

Carcinoma escamoso de cavidad oral en paciente menor de edad

Saura

Jariod

Gavin

et al. 2017

Rev. Otorrinolaringol. Cir. Cabeza Cuello

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Carcinoma of the tongue: A case series analysis of clinical presentation, risk factors, staging, and outcome

Cited by 130 publications

References 28 publications

Intra-arterial chemoradiotherapy for locally advanced oral cavity cancer: analysis of therapeutic results in134 cases

Intra-arterial chemoradiotherapy for locally advanced oral cavity cancer: analysis of therapeutic results in134 cases

The Effect of Correlation Between Prognostic Factors and Long-Term Mortality in Tongue Cancers

Carcinoma escamoso de cavidad oral en paciente menor de edad

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