Carcinoma of the stomach in the young adult

Tamura, Paul Y.; Curtiss, Charlotte

doi:10.1002/1097-0142(196003/04)13:2<379::aid-cncr2820130223>3.0.co;2-f

Cited by 67 publications

(28 citation statements)

References 9 publications

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“…Gastric cancer of youth is predominantly a disease of women, especially among Asians (Tamura and Curtiss, 1960). It is usually of the signet-ring cell rather than the gland-forming subtype and has a predilection for metastasizing to the ovaries (Duarte and Llanos, 1981;Holtz and Hart, 1982).…”

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confidence: 99%

Preferential Loss of Fhit Expression in Signet-Ring Cell and Krukenberg Subtypes of Gastric Cancer

Chang

et al. 2002

Laboratory Investigation

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SUMMARY:Gastric cancer of youth is predominantly a disease of women, usually of the signet-ring cell subtype, with a predilection for metastasizing to the ovaries. The metastatic ovarian tumor is named a Krukenberg tumor. However, the characteristic genetic alterations between the primary gastric cancer and its metastatic ovarian tumor have not been studied. We used laser capture microdissection to procure tissues from 7 patients with gastric cancer who had ovarian metastases (Krukenberg tumor) and tissues from 14 patients with gastric cancer without ovarian metastases. Loss of heterozygosity (LOH) analysis was performed by use of 16 polymorphic markers, which are mapped to the FHIT, APC, p16, BRCA2, p53, BRCA1, and DPC4 loci. Immunohistochemical staining with anti-Fhit antibody was performed in 7 Krukenberg tumors and 92 gastric cancers without ovarian metastases. LOH at the FHIT locus was observed in six (85.7%) of the seven Krukenberg tumors. In contrast, the gastric cancers without ovarian metastases showed a lower frequency (28.6%, 4/14) of LOH at the FHIT locus (p Ͻ 0.05, odds ratio ϭ 1/15). Anti-Fhit antibody showed that expression of Fhit was lost in each of the 7 (100%) Krukenberg tumors but in only 41 (44.6%) of the 92 patients who had gastric cancer without ovarian metastases (p Ͻ 0.05; odds ratio ϭ 1/18.614). Further analysis showed that loss of Fhit expression is highly associated with signet-ring cell type gastric cancer (p Ͻ 0.0001, odds ratio ϭ 62.5) but is not correlated with prognosis. Alteration of the FHIT gene is a characteristic of signet-ring cell type gastric cancer and Krukenberg tumor. (Lab Invest 2002, 82:1201-1208.

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confidence: 99%

Preferential Loss of Fhit Expression in Signet-Ring Cell and Krukenberg Subtypes of Gastric Cancer

Chang

et al. 2002

Laboratory Investigation

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“…The greater vascularity of the ovaries in young female facilitating hematogenous spread is well accepted by many authors [3] [29]. Tamura PY et al did study of gastric carcinoma in young people.…”

Section: Discussionmentioning

confidence: 91%

“…The patients they studied were all less than 36 years. They in their study found the ovaries were involved in 55% of the cases [29]. Few authors favor the theory of hematogenous spread through thoracic duct [30].…”

Section: Discussionmentioning

confidence: 96%

An Up-to-Date Understanding of the “Krukenberg Tumor” Mechanism

Shah¹,

Tang²,

Karn³

2016

ARSci

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Krukenbergtumor is a metastatic ovarian tumor with its primary site being the gastrointestinal tract. The pathogenesis of Krukenberg tumor formation is still in its hypothetical stage though the current understanding suggests lymphatic, hematogenous and transcoelomic route as the 3 major route of metastasis. There is a lack of description in the literature related to the pathway of metastasis. Here, we intend to search the available literature and provide a thorough review, which may be helpful to the readers to understand the issue of mechanism of Krukenberg tumor metastasis more clearly.

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“…The diagnosis was made late in these patients; their younger age was considered to be the major deterrent to making an early diagnosis (Matsusaka et al, 1976;Bloss et al, 1980;Okamoto et al, 1988). Other investigators have reported that the short duration of symptoms before the diagnosis correlated with the patients widespread disease and subsequent short survival (Tamura & Curtiss, 1960;Tso et al, 1987). This was explained as being indicative of rapid growth and dissemination of the tumour.…”

Section: Clinicopathologicalfactorsmentioning

confidence: 96%

“…It has been reported that only about 1-2% of all cases of gastric cancer occur in individuals aged 30 years or younger (Tso et al, 1987;Okamoto et al, 1988;Matley et al, 1988). The prognosis in these young patients has shown considerable variability, with the poor prognosis attributed to a delay in the diagnosis (Matsusaka et al, 1976;Bedikian et al, 1979;Bloss et al, 1980), and to a more aggressive course of disease (Tamura & Curtiss, 1960;Tso et al, 1987). However, the published literature does not make clear whether there are differences in the prognosis between the younger and the older patients.…”

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confidence: 99%