Carcinoma of the Rectum and Anterior Resection

Muir, E. G.

doi:10.1111/j.1445-2197.1958.tb03965.x

Cited by 8 publications

(4 citation statements)

References 5 publications

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“…Purified papain will cause a rapid disintegration of bovine articular cartilage at physiological pH and temperature (Schneider and Goldstein, 1967). A similar effect of papain had been previously demonstrated using chondroprotein from pig laryngeal cartilage as a substrate (Muir, 1958). Due to the temperatures used in most experiments involving papain (37-60) collagen becomes rapidly degraded.…”

Section: Discussionsupporting

confidence: 67%

Properties of a collagen molecule containing three identical components extracted from bovine articular cartilage

Strawich¹,

Nimni²

1971

Biochemistry

146

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Section: Discussionsupporting

confidence: 67%

Properties of a collagen molecule containing three identical components extracted from bovine articular cartilage

Strawich¹,

Nimni²

1971

Biochemistry

146

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“…Even assuming a high molecular weight of 50 000 for the chondroitin sulphate chain, the most abundant amino acid, aspartic acid, would only amount to 0-83 of a residue/mole. Fraction D3 did not appear to resemble the protein-polysaccharide complex isolated by Muir & Jacobs (1967), which contained only about 2% of protein, or the chondroitin sulphate-peptides that result from the action of proteolytic digestion of the proteinpolysaccharide complex (Muir, 1958;Anderson Dl 59.7 3.7…”

Section: Discussionmentioning

confidence: 96%

“…The yield of fraction ED" was 54% of fraction ED'. The final product (fraction ED") from the above procedure was then subjected to precipitation with 9-aminoacridine hydrochloride by a method based on that described by Muir (1958). Fraction ED" (500mg.)…”

Section: Methodsmentioning

confidence: 99%

“…In these studies proteolytic digestion was used to obtain maximum yields of polysaccharide. However, suitable extraction methods have shown that the chondroitin sulphate of epiphysial cartilage (Castellani, Bonferoni, Ronchi, Ferri & Maleovati, 1962;Castellani, Zonta & De Luca, 1965), and of other cartilages, occurs linked through covalent bonds to protein, so forming high-molecular-weight complexes (Shatton & Schubert, 1954;Malawista & Schubert, 1958;Muir, 1958;Partridge & Davis, 1958). It was therefore considered of interest to study the composition of the chondroitin sulphate isolated from bone by relatively mild procedures to see if similar types of protein-bound complexes also occur in this tissue.…”

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confidence: 99%

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Studies on the protein-bound chondroitin sulphate of bovine cortical bone

Herring

1968

Biochemical Journal

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A fraction containing chondroitin sulphate, isolated from bovine cortical bone under mild conditions, was separated by ion-exchange chromatography into three fractions with apparent homogeneity on electrophoresis and ultracentrifugation. Two of these appeared to consist of chondroitin sulphate bound to a glycoprotein ;core' that had similarities to the bone sialoprotein described previously. The differences in composition of the two fractions were considered to be due to variation in the number or lengths of the polysaccharide chains. The presence of xylose and the alkali-lability of the bond between protein and polysaccharide suggested the presence of a xylosylserine linkage. The third fraction had the properties of a relatively pure chondroitin sulphate which contained a small amount of peptide. These fractions differed considerably from the protein-polysaccharide complexes of epiphysial and other cartilages, and their relevance to the possible role of glycosaminoglycans is discussed.

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Anastomotic dehiscence after anterior resection of rectum and sigmoid

Goligher

Graham

Dombal

1970

Journal of British Surgery

396

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SUMMARYI. The incidence of dehiscence of the anastomosis after anterior resection of the sigmoid colon and rectum was studied by digital examination of the rectum, sigmoidoscopy, and radiological examination after a small barium enema in 73 patients who had undergone the operation for carcinoma, villous papilloma, or diverticular disease.2. Dehiscence was detected in 37 (or 51 per cent) of the entire series, in 19 (or 40 per cent) of the 47 cases treated by high anterior resection, and in 18 (or 69 per cent) of the 26 cases submitted to low anterior resection. The dehiscences were usually much more extensive after low resection. The possible reasons for these differences are discussed.3. The effect of other factors on the occurrence of dehiscence was examined :-a. A simultaneous transverse colostomy was performed in 28 of the 68 patients undergoing primary resection. It was used in most cases after low resection, whilst after high resection it was reserved largely for cases with faecal loading. The unfavourable nature of the patients submitted to simultaneous covering colostomy makes it impossible to evaluate the influence of this step on the incidence of dehiscence.b. A preliminary transverse colostomy was established 14-21 days before resection in 5 patients. Three of these cases developed anastomotic dehiscence after the resection, so that clearly an empty distal colon at the time of resection provides no certain guarantee against breakdown of the suture line.c. Preoperative administration of bowel antiseptics in the form of phthalylsulfathiazole and neomycin was associated with a significantly lower rate of dehiscence after high anterior resection, but had no obvious beneficial effect on the incidence of this complication after low resection.4. Though minimal dehiscences, especially after high anterior resection, often pursued an innocuous, subclinical course, major dehiscences endangered the patient's life and prolonged convalescence. There were 2 deaths in this series attributable to dehiscence, a mortality of 2.7 per cent. The mean period in hospital after high anterior resection was 17 days in patients who did not develop dehiscence and 35 days in those who did; and after low anterior resection it was 44 days when dehiscence did not occur and 48 days when it did.WHEN anterior resection with sutured anastomosis was originally advocated by Dixon (1939, 1944), Wangensteen (1945), Waugh and Custer (1945), Mayo and Smith (1948), and Mayo, Lee, and Davis 9* (195 I) for the treatment of certain carcinomas of the rectum and rectosigmoid, one of the fears entertained by many surgeons about this operation was that anastomoses at this level in the intestinal tract might be very liable to leak with resulting serious sepsis. It was, indeed, soon discovered that leakage and infection did sometimes occur after anterior resection, but the incidence of complications from this source was insufficient to prohibit the general adoption of this operation in the cases for which it might be deemed suitable. The precise incidence...

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Carcinoma of the Rectum and Anterior Resection

Cited by 8 publications

References 5 publications

Properties of a collagen molecule containing three identical components extracted from bovine articular cartilage

Properties of a collagen molecule containing three identical components extracted from bovine articular cartilage

Studies on the protein-bound chondroitin sulphate of bovine cortical bone

Anastomotic dehiscence after anterior resection of rectum and sigmoid

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