Carcinoma of the prostate in patients 70 to 79 years old

Halpert, Béla; Schmalhorst, William R.

doi:10.1002/1097-0142(196605)19:5<695::aid-cncr2820190515>3.0.co;2-w

Cited by 45 publications

(22 citation statements)

References 5 publications

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“…Halpert et al 8,9 were the first to briefly describe the clefts in autopsy studies in prostatic adenocarcinoma in 1960's. Our previous studies suggest that periacinar clefting is not simply technical artifact without significance but instead represent the consequence of processes that affected neoplastic acini and surrounding stroma.…”

Section: Discussionmentioning

confidence: 99%

“…11,12,24 The neoplastic cells of prostatic cancer often appear pulled away from the surrounding stroma leaving retraction artifacts around the acini. 8,9 These retraction artifacts, periacinar halos or so-called retraction clefting are often observed, especially in Gleason pattern 3 prostatic carcinomas. It was shown that periacinar retraction clefting represents a reliable criterion for diagnosis of prostatic adenocarcinoma in needle core biopsies, especially in cases with clefts affecting more than 50% of circumference in at least 50% of suspicious glands.…”

Section: Introductionmentioning

confidence: 99%

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Periacinar clefting and p63 immunostaining in prostatic intraepithelial neoplasia and prostatic carcinoma

Krušlin

Tomas

Čviko

et al. 2006

Pathol. Oncol. Res.

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The aim of the present study was to correlate the presence and extent of retraction clefting and the expression of p63 in neoplastic glands and glands with prostatic intraepithelial neoplasia (PIN) in needle core biopsies.We analyzed needle core biopsies from 28 patients with PIN and 41 patients with adenocarcinoma. Neoplastic glands and those with PIN were analyzed on high power field (400x) and classified in three groups. Immunohistochemical staining was performed following Microwave Streptavidin ImmunoPeroxidase (MSIP) protocol on DAKO TechMate Horizon automated immunostainer using antibodies to p63 (4A4, M7247, DAKO, Denmark).Periacinar retraction clefting was significantly more prominent in prostatic carcinoma compared to PIN (p<0.0001) and nonneoplastic glands (p<0.0001). There was no difference between normal glands and PIN regarding clefting (p=0.8064). P63 was positive around whole circumference in 12 out of 28 cases with PIN, and discontinuously positive in remaining 16 PIN cases suggesting initial disruption of basal cell layer. P63 immunostaining was also positive in all nonneoplastic glands, and negative in all carcinoma cases.We conclude that retraction clefting was associated with cancer and lack of basal cells, but not with PIN. The relationship between clefting and p63 immunostaining in prostatic cancer should be further analyzed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Periacinar clefting and p63 immunostaining in prostatic intraepithelial neoplasia and prostatic carcinoma

Krušlin

Tomas

Čviko

et al. 2006

Pathol. Oncol. Res.

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“…The neoplastic cells of prostatic cancer often appear pulled away from the surrounding stroma, leaving empty spaces that completely or partially encircle the acini; these are called retraction clefts or retraction artifacts and were described for the first time in 1960s in autopsy studies by Halpert and co-workers [1,2]. Periacinar retraction clefts in prostatic carcinoma serve as a helpful additional criterion in setting of pathohistological diagnosis, particularly in differentiating it from some benign conditions (atrophy, postatrophic hyperplasia, atypical adenomatous hyperplasia), which may mimic prostatic carcinoma [3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Periacinar Retraction Clefting and D2-40 Expression in Prostatic Adenocarcinoma

Ulamec

Džombeta

Čupić

et al. 2011

Pathol. Oncol. Res.

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Retraction clefting is known to appear in various types of tumors, but it has only recently been recognized as a specific histological phenomenon. Previously, it was considered merely a laboratory procedure artifact, but lately, there have been some assumptions that peritumoral retractions actually represent lymphatic spaces. In our study, we analyzed neoplastic glands in 52 specimens of prostatic adenocarcinoma. Immunohistochemical analysis was performed using D2-40 antibody, to highlight lymphatic endothelium and thereby differentiate actual lymph vessels or lymphovascular invasion from periacinar retractions. Our results showed that the number of lymph vessels was significantly lower in tumorous tissue compared to adjacent normal prostatic tissue. On the other hand, the number of lymph vessels in tumorous tissue was significantly higher than the number of lymph vessels mimicking periacinar retractions. Overall, the number of lymph vessels mimicking periacinar clefts was particularly low. These results are in accordance with our previous studies, which had shown that periacinar clefting appears due to lack of basal cells and stromal changes around tumorous acini. Also, these results support our hypothesis that retractions do not represent lymph vessels but should be considered a distinct entity, which is proven to be helpful both as diagnostic and predictive factor.

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“…Few authors paid attention to the so-called periacinar halos, retraction clefting or cleft-like spaces within neoplastic tissue [3,5,6,7,11]. The neoplastic cells of prostatic cancer often appear pulled away from the surrounding stroma, leaving halos around the acini [5].…”

Section: Introductionmentioning

confidence: 99%

“…The neoplastic cells of prostatic cancer often appear pulled away from the surrounding stroma, leaving halos around the acini [5]. Only a limited number of reports have compared and validated retraction clefting as supportive diagnostic features in needle core biopsies in tumor tissue and benign glands [3,7,11].…”

Section: Introductionmentioning

confidence: 99%

Periacinar retraction clefting in the prostatic needle core biopsies: an important diagnostic criterion or a simple artifact?

et al. 2003

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The diagnosis of prostatic adenocarcinoma in needle core biopsy is based on major and supportive criteria. One of the supportive criteria is the presence of retraction clefting around neoplastic glands. We analyzed a series of 137 prostatic cancer cases diagnosed by needle core biopsy to determine the frequency, extent and criteria for periacinar retraction clefting. Clefting was analyzed on ten neoplastic and ten normal glands in three different high power fields. One-third or more glands with clefts affecting more than 50% of circumference were significantly more common in tumors (51.8%) than in benign glands (8%) (P<0.0001). A stricter criterion that designated as positive the cases with at least 50% of neoplastic glands (15 of 30) with clefts that affected more than 50% of circumference revealed clefts in only 15.3% of the malignant cases but none in benign cases (0%) (P<0.0001). Regardless of their extension, 15 or more glands with clefts were also more prominent in malignant cases (86.9%) than in benign cases (20.4%) (P<0.0001). We conclude that periacinar retraction clefting represents a reliable criterion for diagnosis of the prostatic adenocarcinoma, especially in cases with clefts affecting more than 50% of circumference in at least 50% of suspicious glands.

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Carcinoma of the prostate in patients 70 to 79 years old

Cited by 45 publications

References 5 publications

Periacinar clefting and p63 immunostaining in prostatic intraepithelial neoplasia and prostatic carcinoma

Periacinar clefting and p63 immunostaining in prostatic intraepithelial neoplasia and prostatic carcinoma

Periacinar Retraction Clefting and D2-40 Expression in Prostatic Adenocarcinoma

Periacinar retraction clefting in the prostatic needle core biopsies: an important diagnostic criterion or a simple artifact?

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