Carcinoma of the penis

deKernion, Jean B.; Tynberg, Peter; Persky, Lester; Fegen, J. Peter

doi:10.1002/1097-0142(197311)32:5<1256::aid-cncr2820320534>3.0.co;2-g

Cited by 119 publications

(44 citation statements)

References 16 publications

(1 reference statement)

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“…The prognosis for survival in patients with lymph node metastases is tightly correlated with the number and location of involved lymph nodes and the presence of extranodal extension [6]. …”

Section: Introductionmentioning

confidence: 99%

Multimodality therapy in penile cancer: when and which treatments?

Pagliaro

Crook

2008

World J Urol

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Objectives Metastatic penile cancer typically comes to attention while the clinical extent of disease is limited to the inguinal or pelvic lymph nodes. Primary surgical management of lymph node metastases achieves tumor control and long-term survival for only a small percentage of these patients. To determine the optimal use of multimodality treatment in locally advanced penile cancer, we conducted a literature review. Methods Relevant English-language literature was identified with the use of Medline; additional cited works not detected on the initial search were also reviewed. Results There is an emerging strategy of preoperative (neoadjuvant) combination chemotherapy to improve the progression-free survival of penile cancer patients with bulky regional lymph node metastases. Radiotherapy for inguinal metastases and postoperative (adjuvant) radiation for selected patients has also been effective in this setting. Conclusions In patients with lymph node metastases, the benefit of ilioinguinal lymphadenectomy may be extended by the addition of neoadjuvant chemotherapy. Postoperative radiotherapy can be offered depending on the amount of residual disease after chemotherapy. Chemo-radiotherapy has been successful in squamous cell cancers from other sites (vulva and anal canal) and may be considered for unresectable penile cancer.

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“…The prognosis for survival in patients with lymph node metastases is tightly correlated with the number and location of involved lymph nodes and the presence of extranodal extension [6]. …”

Section: Introductionmentioning

confidence: 99%

Multimodality therapy in penile cancer: when and which treatments?

Pagliaro

Crook

2008

World J Urol

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“…Survival-rate figures vary, but de Kernion et al (1973) found, in carcinoma arising de novo, a threeyear survival rate of 960% with stage 1 lesions (the stage in this case), and von Alth et al (1973) found a five-year survival rate of 84 % at the same stage.…”

Section: Discussionmentioning

confidence: 65%

Carcinoma of the penis developed in lichen sclerosus et atrophicus.

Bingham¹

1978

Sexually Transmitted Infections

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“…Stage Ta or Tis tumours located on the distal prepuce can be cured by circumcision alone, if the surgeon ensures a wide safety margin (2 cm) free of tumour (Dekernion et al, 1973;Bissada, 1992). For stage Tis, Ta or T1 tumours we recommend an organ-preserving therapy.…”

Section: Treatment Of the Primary Lesionmentioning

confidence: 99%

Squamous cell carcinoma of the penis

2009

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Summary. Squamous cell carcinoma of the penis is a rare disease in Western countries. In geographical locations where infantile circumcision is not routinely practised and genital hygiene is poor, penile cancer may comprise 10–20% of all malignancies. Superficial tumours (Ta‐T1) should be treated with organ‐preserving therapy. Partial or total penectomy is recommended for invasive penile carcinoma (stage T2 or higher). Currently, management of the ilioinguinal lymph nodes is controversial. The value of radiation therapy and chemotherapy is still uncertain; these treatments are only palliative therapy modalities.

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Carcinoma of the penis

Cited by 119 publications

References 16 publications

Multimodality therapy in penile cancer: when and which treatments?

Multimodality therapy in penile cancer: when and which treatments?

Carcinoma of the penis developed in lichen sclerosus et atrophicus.

Squamous cell carcinoma of the penis

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