Carcinoma of the pancreas

Cliffton, Eugene E.

doi:10.1016/0002-9343(56)90092-4

Cited by 36 publications

(3 citation statements)

References 167 publications

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“…The sex distribution of 2 males and 6 females, the very favorable stage presentation (3 of 8 localized), and the relatively good survival (2 of 8 patients alive at 3 years) parallel the literature reports (see Clifton, 1959 for a review) and set off these cancers, like the papillary cancers, from other cancers of the exocrine pancreas.…”

Section: Squamous Metaplashsupporting

confidence: 70%

“…Factors that may explain this include (1) the late presentation and therefore dismal prognosis of most patients with this visceral malignancy, (2) the ineffectiveness of available therapy, and (3) the relative infrequency with which this diagnosis is made, accounting for 1 t o 2% of all carcinomas in postmortem series (Clifton, 1959). However, several reportsindicate that the incidence of pancreatic cancer has probably been increasing in recent decades, although the magnitude of the increase is open to some debate (Krain, 1970;Lazar et al, 1960).…”

Section: Introductionmentioning

confidence: 99%

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Cross‐classification and survival characteristics of 5,000 cases of cancer of the pancreas

Baylor

Berg

1973

Journal of Surgical Oncology

224

127

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Over 5,000 histologically confirmed cases of cancer of the pancreas from the End Results Group of cancer registries have been examined for differences in behavior by epidemiologic and pathologic variables. Thirteen percent had a specific histologic diagnosis other than "adenocarcinoma," "carcinoma," or "cancer." The 92 cases of islet cell carcinoma were unique, having a much younger age a t diagnosis (two-thirds instead of one-third diagnosed under the age of 60), a locational preference for the body and/or tail (only 40% instead of 70% occurring in the head of the pancreas), and a very favorable survival experience (15 year relative survival of 14%). Of cancers of the exocrine pancreas, the 64 cases with papillary histology were most distinct, two-thirds being found in women, 18% instead of 10% being localized, and having relatively favorable survival (30% one-year survival, 5% three-year survival). Patients whose tumors revealed squamous metaplasia occurred in general at older ages and had unusually poor survival. Analysis by anatomic location showed an increasing percentage of carcinomas occurring in the head of the pancreas with increasing age. Analysis of "adenocarcinomas" by histologic grade indicated that grade may carry some prognostic information not explained by difference in stage. A striking gradient of decreasing survival with increasing age did not explain, and was not explained by survival gradients in other variables.

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Section: Squamous Metaplashsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Cross‐classification and survival characteristics of 5,000 cases of cancer of the pancreas

Baylor

Berg

1973

Journal of Surgical Oncology

224

127

View full text Add to dashboard Cite

show abstract

“…In Strang and Walton's (2) cases of carcinoma of the body and tail of the pancreas, 29 per cent of the autopsies revealed arterial or venous thrombi. Multiple thrombi are especially significant in association with tumors of the body and tail of the pancreas; the incidence is reported to be 33 per cent (9–11).…”

Section: Discussionmentioning

confidence: 99%