Carcinoma of the larynx

Quayum, MA; Glennie, J.McD.; Orr, J.S.

doi:10.1016/s0009-9260(78)80158-5

Cited by 14 publications

(3 citation statements)

References 6 publications

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“…Eleven patients (48%) were suitable for salvage surgery; 5 patients (45% of operated patients or 22% of all patients with failures) remained alive beyond 5 years. 14 In our study, the 2-and 5-year overall survival rates were 85.7% and 68.6%, respectively. There was a recurrence at 8 months of follow-up after laser surgery in 1 patient, who underwent surgical salvage total laryngectomy.…”

Section: Discussionsupporting

confidence: 45%

“…12 Spriano et al 13 reviewed 15 SCPL salvage patients with a 3-year local control rate of 100%. Quayum et al 14 reported on 23 patients who developed recurrence after radiation failure for supraglottic cancer. Eleven patients (48%) were suitable for salvage surgery; 5 patients (45% of operated patients or 22% of all patients with failures) remained alive beyond 5 years.…”

Section: Discussionmentioning

confidence: 99%

“…Although ours was a small series, these oncological results are comparable to those of open surgery. 3,[12][13][14] Open partial laryngectomy for salvage after failed radiotherapy is more frequently associated with postoperative complications, with reported complication rates of 20% to 28% and with fistula rates of 8% to 14%. [15][16][17] Repair of pharyngocutaneous fistula often requires major flap reconstruction.…”

Section: Discussionmentioning

confidence: 99%

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Salvage Transoral Laser Supraglottic Laryngectomy after Radiation Failure: A Report of Seven Cases

Hong

Kim²,

Lee³

et al. 2013

Ann Otol Rhinol Laryngol

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Section: Discussionsupporting

confidence: 45%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Salvage Transoral Laser Supraglottic Laryngectomy after Radiation Failure: A Report of Seven Cases

Hong

Kim²,

Lee³

et al. 2013

Ann Otol Rhinol Laryngol

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T2 Glottic Cancer: Recurrence, Salvage, and Survival After Definitive Radiotherapy

Howell-Burke

Peters²,

Goepfert³

et al. 1990

Archives of Otolaryngology - Head and Neck Surgery

100

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The records of all patients with T2, NO squamous cell carcinoma of the true vocal cords treated with definitive radiotherapy at The University of Texas M. D. Anderson Cancer Center between 1970 and 1985 were analyzed to investigate treatment outcome, prognostic factors associated with tumor recurrence, and the potential impact of improved initial treatment on patient survival. There were 114 patients (male to female ratio, 13:1) with a median age of 62 years at presentation. All were treated with external beam irradiation to a modal dose of 70 Gy in 35 fractions over 7 weeks. The median field size was 25 cm2 and no elective treatment to the neck was routinely given. The crude recurrence rate after definitive radiotherapy was 32%. Of the 37 local regional failures, 32 were in the larynx only, 3 in the neck, and 2 in both the larynx and the neck. All patients who had recurrence after radiotherapy underwent salvage procedures, which increased the ultimate control rate above the clavicles to 94%. Overall and disease-specific survival rates at 5 years were 69% and 92%, respectively. Fifty patients died: 7 of laryngeal cancer, 2 of complications of salvage surgery, 13 of unrelated second cancers, and 28 of other intercurrent disease. The prospects for improved survival through more effective initial treatment of this stage of glottic cancer are therefore very limited. Significant complications of radiotherapy occurred in only 4 patients (3.5%), and overall, 74% of patients retained a functional larynx. Analysis of a wide variety of patient-, tumor-, and treatment-related variables failed to identify any statistically significant prognostic factors.(ABSTRACT TRUNCATED AT 250 WORDS)

et al. 1987

Journal of Surgical Oncology

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Six hundred sixty-eight patients with tumours of the larynx were treated by radiotherapy. The patients had stage T1 N0 M0 to T4 N3 M0 disease. Patients with T1 N0 M0 disease (273) had an excellent long-term survival (90%) as did those with T2 N0 M0 disease (142), whose 5-year survival was 70%. Patients with more advanced disease but no nodal spread did not respond as readily to radiotherapy; the 5-year survival was 40%. All patients were treated using a parallel pair set-up 6 X 6 cm lateral neck fields. A more aggressive radiotherapy regime to a larger tissue volume to include microscopic spread to lymph nodes may improve survival of locally advanced disease.

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Carcinoma of the larynx — Results of primary radiotherapy

Cited by 14 publications

References 6 publications

Salvage Transoral Laser Supraglottic Laryngectomy after Radiation Failure: A Report of Seven Cases

Salvage Transoral Laser Supraglottic Laryngectomy after Radiation Failure: A Report of Seven Cases

T2 Glottic Cancer: Recurrence, Salvage, and Survival After Definitive Radiotherapy

Carcinoma of the Larynx

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