Carcinoma of the large bowel.Analysis of clinical features in 478 cases, including eighty-eight five-year survivors

Buser, Julian W.; Kirsner, Joseph B.; Palmer, Walter L.

doi:10.1002/1097-0142(1950)3:2<214::aid-cncr2820030204>3.0.co;2-e

Cited by 25 publications

(2 citation statements)

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“…Although not statistically significant, locoregional recurrences showed up later than distant metastases. While these findings are consistent with those of other authors [8–13,21,23–25], we did not observe a longer recurrence interval for colonic than for rectal tumours in contrast to others [23]. The rate and proportion of local or distant recurrences was equally high for both colon and rectal cancer.…”

Section: Discussionsupporting

confidence: 92%

The prognostic impact of the time interval to recurrence for the mortality in recurrent colorectal cancer

et al. 2006

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Section: Discussionsupporting

confidence: 92%

The prognostic impact of the time interval to recurrence for the mortality in recurrent colorectal cancer

et al. 2006

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“…The majority of CRC recurrences are known to occur within 2 years of curative treatment, with over 80% occurring within 3 years and 90–95% by 5 years (Table ). Interestingly, the distribution of time to recurrence appears to have changed little over more than 60 years, despite advances in preoperative diagnosis, surgical technique and adjuvant therapies . Many studies either fail to mention follow‐up duration or are limited by a short minimum follow‐up time, resulting in the potential to overestimate the proportion of early recurrences and miss late ones.…”

Section: Introductionmentioning

confidence: 99%

When does curatively treated colorectal cancer recur? An Australian perspective

Reece

Chapuis

Keshava

et al. 2018

ANZ Journal of Surgery

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Background: While most colorectal cancer (CRC) recurrences reportedly occur within 3 years following curative treatment, many studies are limited by short-term follow-up. This study examines the time to recurrence of CRC in a large Australian cohort with a long follow-up period and assesses whether time to recurrence has changed over time.Methods: A comprehensive prospective database of patients undergoing resection for CRC is maintained at Concord Hospital, Sydney. Demographic and time to recurrence data were extracted for patients who developed a recurrence following potentially curative resection for colon cancer from 1995 to 2010 and rectal cancer from 1971 to 2010. Non-deceased patients had a minimum of 5 years follow-up. Results: Between 1995 and 2010, 2575 patients with CRC underwent surgery. After exclusions, 386 had recurrence following potentially curative resection, ranging from 1 to 172.5 months (median 20.3) after treatment. Within 1 year, 27.5% recurred, 57.5% by 2 years, 74.6% by 3 years, 85.5% by 4 years and 89.6% by 5 years. There was no difference in time to recurrence between colon and rectal cancers (P = 0.674). Among patients having a potentially curative resection for rectal cancer between 1971 and 2010, 386 recurred. There was no difference in time to recurrence by decade (P = 0.863). Conclusion: The majority of recurrences occurred within 3 years of curative treatment. Had surveillance been limited to 5 years, detection of more than 10% of recurrences would have been delayed. Time to recurrence for rectal cancer has not changed in over 40 years, despite treatment advances.

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Cancer of the cecum

Costello

1952

Cancer

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Carcinoma of the large bowel.Analysis of clinical features in 478 cases, including eighty-eight five-year survivors

Cited by 25 publications

References 10 publications

The prognostic impact of the time interval to recurrence for the mortality in recurrent colorectal cancer

The prognostic impact of the time interval to recurrence for the mortality in recurrent colorectal cancer

When does curatively treated colorectal cancer recur? An Australian perspective

Cancer of the cecum

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