Carcinoma of the cervix: An attempt to individualize treatment

Zander, J.; Baltzer, J.; Lohe, K. J.; Ober, K. G.; Kaufmann, C.

doi:10.1016/0002-9378(81)90539-1

Cited by 87 publications

(18 citation statements)

References 7 publications

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“…Because of the extensive nature of this surgery, a significant complication rate may occur (11). The rates reported in the literature vary from 26.7% to 50% (3,12,13), as compared to 37.5% in our series. The complications observed in our patients were minor, as indicated in Tables 2 and 3.…”

Section: Discussioncontrasting

confidence: 44%

“…There was no intraoperative mortality, with deaths occurring only 30 days after surgery due to excessive immediate postoperative bleeding followed by urinary fistulas. Higher death rates have been reported in the literature (5,6,13,14). The same was observed with respect to the rate of intraoperative complications (8.6%) compared to those reported by others (3,12).…”

Section: Discussionmentioning

confidence: 67%

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Complications of surgical treatment of cervical carcinoma

Abräo¹,

Breitbarg²,

Oliveira³

et al. 1997

Braz J Med Biol Res

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A total of 302 patients with stage Ib and IIa cervical carcinoma were submitted to radical hysterectomy and lymphadenectomy during the period from 1980 to 1994. The morbidity rate was 37.5% and the mortality rate 0.6%. The most common intraoperative complications were injuries to the great pelvic vessels and the most frequent postoperative complications involved the urinary tract. The leading causes of morbidity were urinary infection (20.8%), bladder dysfunction (9.2%) and ureteral fistulas (2.9%). Although the rate of complications was high, morbidity has been decreasing over the last five years. Thus, radical hysterectomy continues to be one of the methods for the treatment of early cervical carcinoma that presents an acceptable 5-year survival rate.

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Section: Discussioncontrasting

confidence: 44%

Section: Discussionmentioning

confidence: 67%

Complications of surgical treatment of cervical carcinoma

Abräo¹,

Breitbarg²,

Oliveira³

et al. 1997

Braz J Med Biol Res

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“…22 We submit that the risk of this bias affecting our results is small for two reasons. First, radical surgery and radiotherapy are of demonstrated efficacy in curing 99% of stage Ia and 85-90% of stage Ib cervical cancers, [23][24][25][26] independent of method of diagnosis. Second, as noted by DiSaia and Creasman, more than 75% of patients who experience recurrence following treatment of cervical cancer do so within two years of diagnosis, and 85% of deaths from disease occur within three years of the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Stage at Diagnosis and Mortality in Patients with Adenocarcinoma and Adenosquamous Carcinoma of the Uterine Cervix Diagnosed as a Consequence of Cytologic Screening

et al. 2003

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“…Postoperative pelvic radiation for patients with lymph node metastases and parametrial extension of lymph-blood vessel invasion has been investigated in several studies. Some authors reported a slightly improved survival rate [41,53,68,86], but the majority [13,16,30,47,60,91,120,139] did not find a better survival rate with this additional treatment. Unfortunately all these studies were retrospective and used non-randomized analysis.…”

Section: The Impact Of Treatmentmentioning

confidence: 99%

“…Patient selection according to the tumor characteristics, as discussed in this article, is more accurate, but is possible only by careful standardized examination of the surgical specimen after surgical treatment. Modifications of standard treatment on the basis of pathologic parameters have been suggested by several other authors [5,16,47,49,95,119,139].…”

Section: The Main Prognostic Factorsmentioning

confidence: 99%

A review of prognostic factors in early-stage carcinoma of the cervix (FIGO I B and II A) and implications for treatment strategy

Bommel¹,

Lindert²,

Kock³

et al. 1987

European Journal of Obstetrics & Gynecology and Reproductiv

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Several prognostic factors in stages I B and II A cervical carcinoma have been widely studied to define groups of patients with a poor prognosis. Most of these factors are interrelated. The characteristics which should be regarded as main factors have not yet been defined, because the studies reported were based on mainly retrospective and non-randomized analysis. Reviewing the literature, lymph node metastasis, differentiation grade, tumor size, parametrial extension, lymphblood vessel invasion and cervical invasion seem to be prognostically important factors, which suggests that the subdivision of patients according to the FIG0 classification alone is inaccurate. It seems useful to define subgroups of patients according to tumor characteristics, determined after surgical treatment and accurate histologic examination of the surgical specimen. Patients with one or more of these tumor features need additional treatment to improve survival. The current treatment modalities, such as postoperative radiotherapy, have not been thoroughly evaluated, but doubt exists as to their efficacy. Data in the literature suggest that particularly patients with para-aortic or multiple pelvic lymph node metastasis (> 3) have already developed distant metastases at the time of primary treatment and therefore need adjuvant systemic therapy. Patients with tumors larger than 4 cm in diameter, differentiation grade III, lymph-blood vessel invasion or cervical invasion (of more than 70%) seem to have high recurrence rates at both pelvic and distant sites, indicating that there is also a need for better pelvic control.

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Carcinoma of the cervix: An attempt to individualize treatment

Cited by 87 publications

References 7 publications

Complications of surgical treatment of cervical carcinoma

Complications of surgical treatment of cervical carcinoma

Stage at Diagnosis and Mortality in Patients with Adenocarcinoma and Adenosquamous Carcinoma of the Uterine Cervix Diagnosed as a Consequence of Cytologic Screening

A review of prognostic factors in early-stage carcinoma of the cervix (FIGO I B and II A) and implications for treatment strategy

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