Carcinoma of the Bladder Treated by Interstitial Irradiation

Williams, Grant; Trott, P. A.; Bloom, H. J. G.

doi:10.1111/j.1464-410x.1981.tb06092.x

Cited by 11 publications

(5 citation statements)

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“…All patients received EBRT before BT except for two studies. In one of these studies patients received BT as a monotherapy with or without adjuvant chemotherapy [20]; and in the other, BT was delivered as a monotherapy, with EBRT or RC being offered if unsuccessful [21]. BT was delivered via a range of techniques.…”

Section: Resultsmentioning

confidence: 99%

“…Based on this approach, bladder preservation with CMT‐BT could also be considered with the option of a salvage cystectomy if required. The average LR rate across all of studies was 14% (0–32%), although some studies did report higher LR rates (>30%) [21,26,27]. For example, in the study by van der Steen‐Banasik et al [26] there was a 33% LR rate within the bladder, of which 11.8% were recurrences within the previous BT field.…”

Section: Discussionmentioning

confidence: 99%

“…Other AEs directly related to the BT catheters were rare. However, in the study by Moonen et al [32], two patients had their sigmoid colon perforated due to improper placement of the BT catheters, and death has also been reported due to surgical complications (2.2%) [16,21]. In the studies with robust reporting of AEs, the acute Grade 5 complication rate was 0.2%.…”

Section: Discussionmentioning

confidence: 99%

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Overall survival, disease‐specific survival and local recurrence outcomes in patients with muscle‐invasive bladder cancer treated with external beam radiotherapy and brachytherapy: a systematic review

et al. 2020

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Registration: PROSPERO registration number is: CRD42019129349. ConclusionBrachytherapy as part of CMT for MIBC is not a standard technique. It is an effective treatment in experienced centres for a selected patient population who wish to preserve their bladder. In such patients, CMT-BT is well tolerated with an acceptable safety profile.Keywords muscle-invasive bladder cancer, interstitial brachytherapy, external beam radiotherapy, organ preservation

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Overall survival, disease‐specific survival and local recurrence outcomes in patients with muscle‐invasive bladder cancer treated with external beam radiotherapy and brachytherapy: a systematic review

et al. 2020

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“…However, Buschke and Jack [15] mentioned that bladder cancer responded poorly to doses that could be given safely by external beam irradiation. From this viewpoint a variety of meth ods have been employed including insertion of encapsu lated sources [16], interstitial radium implantation [17,18] or intra-operative radiation [19], These techniques deliver a high dose to the bladder cancer and spare vul nerable adjacent tissues and organs. However, even these methods have several problems, including long irradia tion time, radiation exposure to the staff, and opera tional difficulty.…”

Section: Discussionmentioning

confidence: 99%

Combination Therapy with Microwave Coagulation and Intracavitary Irradiation for Bladder Cancer

Harada¹,

Kigure²,

Miyagata³

et al. 1988

Urol Int

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Twenty-five patients with transitional cell carcinoma of the bladder have been treated with combined therapy consisting of microwave regional coagulation and intracavitary irradiation. A remote-controlled after-loading system was utilized for the radiation therapy. The follow-up period ranged from 6 to 19 months with an average of 11.4 months. Tumor stages were Tis (n = 2), Ta or T₁ (n = 17), T₂ (n = 2), T₃ (n = 3) and T₄ (n = 1), and grades were G₁ (n = 10), G₂ (n = 11) and G₃ (n = 4). In 23 patients (92%), there was no endoscopic or histologic evidence of tumor after the initial treatment. Heterotopic recurrences were found after 2 or 3 months in 3 patients who received microwave regional coagulation or intracavitary regional irradiation. Additional intracavitary whole bladder mucosal irradiation was performed for 10 patients with multiple tumors and frequent recurrent tumors. Nine patients had no recurrence (average follow-up 11 months). Our preliminary findings indicate that combination therapy of microwave coagulation and intracavitary irradiation is a useful treatment for bladder cancer.

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“…To our knowledge, the idea of interstitial radiotherapy (IRT) for tumors by radium was developed in Paris in the first decade of the 20th century. Shortly afterwards, reports emerged from several centers in Europe and the United States of America concerning IRT in bladder cancer by permanent implantation of radon seeds (2,12,21,23,30,52) or gold grains (8,32,55), or by temporary insertion of radium needles (8,10,21,24,27,43) or cobalt needles (38), or of tantalum wires (5,38,51,55), or iridium wires (35).…”

Section: Introductionmentioning

confidence: 99%

143 Muscle invasive bladder cancer treated by transurethral resection, followed by external beam radiation and interstitial iridium-192

Wijnmaalen¹,

Helle²,

Koper³

et al. 1996

International Journal of Radiation Oncology*Biology*Physics

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Purpose: To evaluate the results of transurethral resection (TUR), external beam radiotherapy (EBRT), and interstitial radiation (IRT) with iridium-192, using the afterloading technique in patients with muscle invasive bladder cancer. Methods and Materials: From May 1989 until September 1995,66 patients with primary, solitary muscle invasive bladder cancer were treated with TUR, EBRT, and IRT, aiming at bladder preservation. According to the protocol, in three patients low-dose EBRT was applied, whereas 63 patients received high-dose EBRT. Immediately prior to IRT, 42 patients underwent a lymphnode dissection, and in 16 cases a partial cystectomy was performed. For IRT, two to five catheters were used and IRT was started within 24 h after surgery. The majority of patients received 30 Gy of IRT, with a mean dose rate of 58 Gy/h. In three patients, additional EBRT was applied following IRT. Follow-up consisted of regular cystoscopies, mostly done during joint clinics of urologist and radiation oncologist, with urine cytology routinely performed. The median follow-up period was 26 months. The Kaplan-Meier method was used for the determination of survival rates. Results: In seven patients, a bladder relapse developed. The probability of remaining bladder relapse free at 5 years was 88%. The bladder was preserved in 98% of the surviving patients. Metastases developed in 16 patients, and the probability of remaining metastasis free at 5 years was 66%. The cumulative 5-year overall and bladder and distant relapse free survival were 48% and 69%, respectively. Acute toxicity was not serious in the majority of cases; surgical correction of a persisting vesicocutaneous fistula was necessary in two patients, whereas a wound toilet had to be performed in another patient. Serious late toxicity (bladder, RTOG Grade 3) was experienced by only one patient. Conclusions: Interstitial radiation preceded by TUR and EBRT, in a selected group of patients with muscle invasive bladder cancer, yields an excellent bladder tumor control rate with a high probability of bladder preservation. Survival was mainly dependent on the development of distant me&stases. Serious acute and late toxicity was rare.

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Carcinoma of the Bladder Treated by Interstitial Irradiation

Cited by 11 publications

References 5 publications

Overall survival, disease‐specific survival and local recurrence outcomes in patients with muscle‐invasive bladder cancer treated with external beam radiotherapy and brachytherapy: a systematic review

Overall survival, disease‐specific survival and local recurrence outcomes in patients with muscle‐invasive bladder cancer treated with external beam radiotherapy and brachytherapy: a systematic review

Combination Therapy with Microwave Coagulation and Intracavitary Irradiation for Bladder Cancer

143 Muscle invasive bladder cancer treated by transurethral resection, followed by external beam radiation and interstitial iridium-192

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