Overall survival, disease‐specific survival and local recurrence outcomes in patients with muscle‐invasive bladder cancer treated with external beam radiotherapy and brachytherapy: a systematic review

Mannion, Liam; Bosco, Cecilia; Nair, Rajesh; Mullassery, V.; Enting, Deborah; Jones, Emma; Hemelrijck, Mieke Van; Hughes, Simon

doi:10.1111/bju.15047

Cited by 7 publications

(5 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Brachytherapy procedure is based on an already previously meticulously described robot-assisted laparoscopic technique [2,5]. Several publications have already demonstrated the oncological effectiveness of this treatment [6][7][8][9][10], reporting an average 5-year disease-specific survival of 75.2%, a local failure rate of 14% [11], and less toxicity and complications compared with RC [6,10]. However, this treatment option is not always discussed with patients, and is thereby confined to highly specialized centers, predominantly in The Netherlands [11].…”

Section: Purposementioning

confidence: 99%

Quality of life of muscle-invasive bladder cancer patients after brachytherapy-based treatment: A cross-sectional study

Scheltes¹,

Steen-Banasik²,

Smits³

2023

jcb

View full text Add to dashboard Cite

Purpose:To determine the quality of life (QoL) of patients with muscle-invasive bladder cancer (MIBC) who underwent bladder-sparing treatment with high-dose-rate brachytherapy, and compare their QoL with an age-matched general Dutch population.Material and methods: We conducted a single-center, prospective, descriptive cross-sectional study. MIBC patients who underwent brachytherapy-based bladder sparing treatment in Arnhem, The Netherlands from January 2016 to June 2021, were requested to complete the following questionnaires: European Organization for Research and Treatment of Cancer (EORTC) generic (QLQ-C30), bladder cancer-specific (QLQ-BLM30), and expanded prostate cancer index composite bowel (EPIC-50). Mean scores were calculated and compared with general Dutch population.Results: The mean global health status/QoL score of the treated patients was 80.6. High scores were noted in the functional scales, including physical (86.8), role (85.6), emotional (88.6), cognitive (88.3), and social functioning (88.9), while the main reported complains were related to fatigue (21.9) and urinary symptoms (25.1). Compared to the general Dutch population, significant differences were visible in global health status/QoL (80.6 vs. 75.7), pain (9.0 vs. 17.8), insomnia (23.3 vs. 15.2), and constipation (13.3 vs. 6.8). However, in no case did the mean score differ by more than ten points, which was considered clinically relevant.Conclusions: With a mean global health status/QoL score of 80.6, the patients after brachytherapy-based bladder sparing treatment have a good QoL. We found no clinically relevant difference in QoL comparing with an age-matched general Dutch population. The outcome strengthens the idea that this treatment option should be discussed with all patients eligible for brachytherapy-based treatment.

show abstract

Section: Purposementioning

confidence: 99%

Quality of life of muscle-invasive bladder cancer patients after brachytherapy-based treatment: A cross-sectional study

Scheltes¹,

Steen-Banasik²,

Smits³

2023

jcb

View full text Add to dashboard Cite

show abstract

“…По этой причине изучение частоты возникновения местных рецидивов наряду с исследованием отдаленного метастазирования имеет важное значение при оценке специфической смертности больных РМП после РЦ. После РЦ тазовые рецидивы уротелиального рака возникают относительно редко: частота их возникновения, в зависимости от стадии первичной опухоли, находится в диапазоне от 4 до 34 % [1,2,4,5,10,[15][16][17][18][19][20][21][22][23][24][25][26].…”

Section: оригинальные статьиunclassified

Local recurrences after radical cystectomy in bladder cancer patients

Komyakov

Saad

Фадеев

et al. 2023

Urology reports (St. - Petersburg)

View full text Add to dashboard Cite

BACKGROUND: Radical cystectomy is the standard treatment for patients with muscle-invasive bladder cancer and superficial neoplasms in cases of resistance to intravesical immunochemotherapy. AIM: To establish the frequency of local pelvic recurrence in patients with bladder cancer after radical cystectomy. MATERIALS AND METHODS: From 1997 to 2022 radical cystectomy was performed in 407 patients with bladder cancer: 344 (84.5%) men and 63 (15.5%) women. Orthotopic urinary diversion methods were performed in 302 (74.2%) patients, including gastrocystoplasty 24 (5.9%), ileocystoplasty 253 (63.8%) and sigmocystoplasty 25 (6.1%) patients. Continent skin diversion of urine was performed in 13 (3.2%) patients, ureter transplantation into the sigmoid colon in 42 (10.3%) patients, and ureterocutaneostomy in 50 (12.3%) patients. RESULTS: Local recurrence in the pelvis after radical cystectomy was observed in 33 (8.1%) patients: 27 (81.8%) men and 6 (18.2%) women. The average age of men with relapses was 58.7 11.7 years (from 43 to 73 years), women 50.0 7.8 years (from 24 to 65 years). Simultaneous metastatic lesions of internal organs were detected in 6 (18.2%) patients. Local pelvic recurrence after radical cystectomy occurred more often in lymphopositive patients with extravesical spread of the primary low-grade tumor. The median time from radical cystectomy to detection of pelvic recurrence was 7.0 months, from the moment of detection of pelvic recurrence to the death of the patient 4.5 months. CONCLUSIONS: The frequency of local pelvic recurrence of bladder cancer after radical cystectomy is 8.1%. The survival rate of patients with local pelvic recurrence is extremely low.

show abstract

“…Whole bladder radiotherapy has been the accepted convention even in the presence of unifocal disease possibly because of the difficulty in identifying the tumor within the bladder on CT and the historical inaccuracies of treatment delivery described above. Nevertheless, evidence to date supports that partial bladder irradiation is likely to be safe (3,(101)(102)(103).…”

Section: Enabling Tumor-focused Partial Bladder Irradiationmentioning

confidence: 99%

“…Bladder brachytherapy has been used for a highly select patient population with unifocal small lesions (≤50 mm) achieving similar outcomes to a matched population undergoing radical cystectomy (104). It is not widely accepted or recommended as an organconserving treatment option mainly because technical expertise is confined to highly specialized centers and no randomized control data is available (3,101).…”

Section: Enabling Tumor-focused Partial Bladder Irradiationmentioning

confidence: 99%

MR-Guided Adaptive Radiotherapy for Bladder Cancer

et al. 2021

View full text Add to dashboard Cite

Radiotherapy has an important role in the curative and palliative treatment settings for bladder cancer. As a target for radiotherapy the bladder presents a number of technical challenges. These include poor tumor visualization and the variability in bladder size and position both between and during treatment delivery. Evidence favors the use of magnetic resonance imaging (MRI) as an important means of tumor visualization and local staging. The availability of hybrid systems incorporating both MRI scanning capabilities with the linear accelerator (MR-Linac) offers opportunity for in-room and real-time MRI scanning with ability of plan adaption at each fraction while the patient is on the treatment couch. This has a number of potential advantages for bladder cancer patients. In this article, we examine the technical challenges of bladder radiotherapy and explore how magnetic resonance (MR) guided radiotherapy (MRgRT) could be leveraged with the aim of improving bladder cancer patient outcomes. However, before routine clinical implementation robust evidence base to establish whether MRgRT translates into improved patient outcomes should be ascertained.

show abstract

Overall survival, disease‐specific survival and local recurrence outcomes in patients with muscle‐invasive bladder cancer treated with external beam radiotherapy and brachytherapy: a systematic review

Cited by 7 publications

References 42 publications

Quality of life of muscle-invasive bladder cancer patients after brachytherapy-based treatment: A cross-sectional study

Quality of life of muscle-invasive bladder cancer patients after brachytherapy-based treatment: A cross-sectional study

Local recurrences after radical cystectomy in bladder cancer patients

MR-Guided Adaptive Radiotherapy for Bladder Cancer

Contact Info

Product

Resources

About