Carcinoma of pancreas simulating giant cell tumor of bone. Electron-microscopic evidence of its acinar cell origin

Rosal, J.

doi:10.1002/1097-0142(196808)22:2<333::aid-cncr2820220210>3.0.co;2-a

Cited by 230 publications

(103 citation statements)

References 19 publications

(3 reference statements)

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“…UCWOGC of the pancreas was reported first by Rosai in 1968 as "carcinoma of the pancreas simulating giant cell tumor bone" (21). The origin of these osteoclast-like giant cells has yet to be determined.…”

Section: Discussionmentioning

confidence: 99%

Effective Use of Gemcitabine in the Treatment of Undifferentiated Carcinoma with Osteoclast-Like Giant Cells of the Pancreas with Portal Vein Tumor Thrombus

et al. 2012

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A 74-year-old woman had an undifferentiated carcinoma with osteoclast-like giant cells (UCWOGC) in the body of the pancreas with massive portal vein tumor thrombus (PVTT). Because the PVTT progressed so rapidly into the right portal branch, the patient first underwent distal pancreatectomy and tumor thrombectomy to prevent life-threatening portal venous obstruction. Although a recurrent PVTT had developed early postoperatively, systemic gemcitabine treatment was so effective that it induced complete remission 5 months after the initiation of chemotherapy. The patient continued to be in complete response for 12 months, and has survived for 19 months since surgery.

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Section: Discussionmentioning

confidence: 99%

Effective Use of Gemcitabine in the Treatment of Undifferentiated Carcinoma with Osteoclast-Like Giant Cells of the Pancreas with Portal Vein Tumor Thrombus

et al. 2012

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“…Some authors have divided GCT further into two distinct types [11] . Osteoclastic-giant cell tumors are neoplasms dominated by benign-appearing osteoclastlike giant-cells closely resembling conventional giant-cell tumor of bone [12] . ( Figure 1A and B) Pleomorphic giantcell tumor is a highly anaplastic malignancy with bizarre pleomorphic mononucleated and multinucleated giantcells.…”

Section: Introductionmentioning

confidence: 99%

Osteoclastic and pleomorphic giant cell tumors of the pancreas: A review of clinical, endoscopic, and pathologic features

Moore

Bentz²,

Hilden³

et al. 2010

WJG

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Giant cell tumors of the pancreas come in three varieties-osteoclastic, pleomorphic, and mixed histology. These tumors have distinctive endoscopic, clinical, and cytological features. Giant cell tumors have a controversial histogenesis, with some authors favoring an epithelial origin and others favoring a mesenchymal origin. The true origin of these lesions remains unclear at this time. These are also very rare tumors but proper identification and differentiation from more common pancreatic adenocarcinoma is important. The risk factors of these tumors and the prognosis may be different from those associated with standard pancreatic adenocarcinoma. Recognition of these differences can significantly affect patient care. These lesions have a unique appearance when imaged with endoscopic ultrasound (EUS), and these lesions can be diagnosed via EUS guided Fine Needle Aspiration (FNA). This manuscript will review the endoscopic, clinical, and pathologic features of these tumors.

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“…OGCTP, which was first described in 1968 by Rosai [3], is a rare occurrence making up 1% of all pancreatic malignancies. Although reports of OGCTP have been increasing over the last decade, there are few reports which describe the clinical aspects and imaging features of this rare neoplasm of the pancreas.…”

Section: Discussionmentioning

confidence: 99%

A case report of undifferentiated carcinoma with osteoclast-like giant cells of the pancreas and literature review

Togawa

Tonouchi

Chiku

et al. 2010

Clin J Gastroenterol

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Osteoclast-like giant cell tumors rarely arise in the pancreas. Here we report the case of a 78-year-old woman who was diagnosed with a well-defined 3 cm multilocular mass in the pancreatic body by the use of ultrasonography, computed tomography and magnetic resonance imaging. The rim and the septa of the tumor were well enhanced. The distal pancreas was removed with the spleen and the peripancreatic lymph nodes. Macroscopically, the mass was composed predominantly of a multilocular cystic tumor filled with hemorrhagic necrosis, and partly composed of solid components. A histopathological study showed a proliferation of multinucleated osteoclast-like giant cells and spindle cells. Although the predominant tumor cells were strongly positive for vimentin and CD68 and negative for epithelial markers, there were some sparsely scattered cytokeratin-positive neoplastic glands. Seventeen months after surgery, the patient is still alive and has had no recurrence. Below we review 32 cases of osteoclast-like giant cell tumor of the pancreas that have been reported in English literature since 2000.

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Carcinoma of pancreas simulating giant cell tumor of bone. Electron-microscopic evidence of its acinar cell origin

Cited by 230 publications

References 19 publications

Effective Use of Gemcitabine in the Treatment of Undifferentiated Carcinoma with Osteoclast-Like Giant Cells of the Pancreas with Portal Vein Tumor Thrombus

Effective Use of Gemcitabine in the Treatment of Undifferentiated Carcinoma with Osteoclast-Like Giant Cells of the Pancreas with Portal Vein Tumor Thrombus

Osteoclastic and pleomorphic giant cell tumors of the pancreas: A review of clinical, endoscopic, and pathologic features

A case report of undifferentiated carcinoma with osteoclast-like giant cells of the pancreas and literature review

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