Carcinoma Metastatic to the Eye and Orbit

Ferry, Andrew P.; Font, Ramon L.

doi:10.1001/archopht.1974.01010010286003

Cited by 598 publications

(99 citation statements)

References 12 publications

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“…Similar to what has been described about carcinoma metastatic to the eye and orbit [5], most of the METs are metastases from a BC. This was the case in 41 of 88 reported cases in a literature review performed by Mansour and Hidayat [2].…”

Section: Commentsupporting

confidence: 65%

Breast Carcinoma Metastatic to the Eyelid Presenting as the First Sign of Insufficient Chemotherapy

Colombo¹,

Cursiefen²,

Holbach³

2001

Ophthalmologica

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Metastatic eyelid tumors are uncommon. Their presentation may vary markedly. We describe a 61-year-old female who presented with a tender nodule in her right upper eyelid shortly after chemotherapy for metastatic disease. She had undergone right mastectomy and radiotherapy because of an adenocarcinoma 16 years ago. Histopathologic findings were consistent with metastatic carcinoma. Knowledge of the diverse clinical and histopathologic features of metastatic breast carcinoma to the eyelids is essential for the appropriate management of these patients. Breast carcinoma metastatic to the eyelid represented in this patient the only sign of insufficient chemotherapy.

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Section: Commentsupporting

confidence: 65%

Breast Carcinoma Metastatic to the Eyelid Presenting as the First Sign of Insufficient Chemotherapy

Colombo¹,

Cursiefen²,

Holbach³

2001

Ophthalmologica

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“…Breast carcinoma is the most common primary tumor producing metastasis to the anterior uvea, the next common being lung cancer [1, 7]. Metastasis to the anterior segment was observed in 11.4% of cases.…”

Section: Discussionmentioning

confidence: 99%

“…Breast carcinoma disseminates to the intraocular structures more often than to the eyelids and orbit, and within the globe the choroid is more commonly involved than the iris and ciliary body [1, 2]. The incidence of ocular metastasis among patients with breast carcinoma has been reported to vary from 9.7 to 47% [3, 4, 5, 6, 7].…”

Section: Introductionmentioning

confidence: 99%

“…Most of the patients have a history of breast cancer, and ocular involvement is typically preceded by pulmonary dissemination and occurs concurrently with or before central nervous system involvement [5]. However, metastatic ocular disease has been reported to appear first in patients with clinically undetected breast carcinoma [1, 3, 5, 8, 9]. We report a case of metastatic breast carcinoma to the iris, ciliary body and episcleral tissues in a female patient who presented with clinical features of acute narrow-angle glaucoma.…”

Section: Introductionmentioning

confidence: 99%

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Anterior Uveal and Episcleral Metastases from Carcinoma of the Breast

Reddy

Mutum

2000

Ophthalmologica

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Breast carcinoma is the most common primary tumor producing intraocular metastasis. Metastases to the iris and ciliary body are relatively rare. The authors report a case of a 61-year-old lady, operated for carcinoma of the left breast 3 years back, who presented with symptoms and signs of acute narrow-angle glaucoma in the right eye. A diffuse whitish plaque-like mass in the upper nasal quadrant of the iris with an episcleral nodule on the limbus in the corresponding area and all the signs of acute narrow-angle glaucoma were present in the right eye. Intraocular pressure was controlled medically. Fine-needle aspiration cytology from the episcleral nodule showed malignant cells. Histopathology of the excised nodule showed metastatic poorly differentiated carcinoma, and the cellular pattern was similar to the carcinoma of the breast. There was no other metastasis anywhere in the body. Fine-needle aspiration cytology from an external lesion of the eye is a less invasive and easier procedure than paracentesis to diagnose the metastatic nature of the lesions. The rare features in our case are the clinical presentation as acute glaucoma and the ocular structures being the first and only site of metastasis.

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“…Genitourinary cancers may access this route via pre-existing pulmonary metastases or through Batson's plexus. 27 This valveless venous plexus connects the pelvic veins to the vertebral veins. 28 Tumour cells within the plexus may access the cranial venous sinuses and, subsequently, the ophthal- mic veins via changes in venous pressure.…”

Section: Epidemiology and Pathophysiologymentioning

confidence: 99%

Genitourinary malignancy presenting as an ocular metastasis: A case report and review of the literature

Lefresne¹,

Fairchild²,

Johnson³

et al. 2012

CUAJ

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E67Case report Genitourinary malignancy presenting as an ocular metastasis: A case report and review of the literature Cite as: Can Urol Assoc J 2012;6(2):e67-71. http://dx.doi.org/10.5489/cuaj.10174 AbstractMetastases to the eye or orbit as the initial presentation of genitourinary malignancy are unusual and can be a diagnostic challenge. We report an 81-year-old man who presented with pain and proptosis in an eye that had been blind for 50 years. Radiologic investigations identified a mass involving the left globe and orbit. Histology of the enucleation specimen was consistent with a metastatic poorly differentiated carcinoma suggestive of a prostate primary. With the constellation of obstructive urinary symptoms, an abnormal digital rectal examination, elevated prostate-specific antigen and a positive bone scan, androgen deprivation therapy was initiated for metastatic prostate cancer. After an initial response to treatment, the patient's disease progressed in a manner atypical for prostate cancer. After describing our case, we review the literature on ocular and orbital metastases and their relation to genitourinary malignancies.

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Carcinoma Metastatic to the Eye and Orbit

Cited by 598 publications

References 12 publications

Breast Carcinoma Metastatic to the Eyelid Presenting as the First Sign of Insufficient Chemotherapy

Breast Carcinoma Metastatic to the Eyelid Presenting as the First Sign of Insufficient Chemotherapy

Anterior Uveal and Episcleral Metastases from Carcinoma of the Breast

Genitourinary malignancy presenting as an ocular metastasis: A case report and review of the literature

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