Carcinoma de tiroides. Clasificaci?n. Manifestaciones cl?nicas. Diagn?stico. Actitudes terap?uticas. TSHrh y tiroglobulina s?rica en el manejo del carcinoma diferenciado tiroideo

Rigopoulou, D.; Lobo, Ignacio; Iglesias, Sonsoles Guadalix; Gutiérrez, María Calatayud

doi:10.1016/s0211-3449(08)73178-3

Cited by 2 publications

(3 citation statements)

References 32 publications

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“…The fact that the thyroid lesion stained positive for calcitonin (CT) and synaptophysin (SYN) antibodies supported the diagnosis of MTC, while the negative immunoreactivity for TG ruled out follicular thyroid carcinoma. In the immunohistochemical diagnosis of MTC, CT is the most specific and reliable marker for this type of tumor (Patnaik and Lieberman, 1991;Rigopoulou et al, 2008), while SYN, in determining its neuroendocrine origin, is the perfect complement (Gould et al, 1987). In this case, the combination of the three markers confirmed the diagnosis of MTC.…”

Section: Introductionmentioning

confidence: 99%

Multiple endocrine neoplasia similar to human subtype 2A in a dog: Medullary thyroid carcinoma, bilateral pheochromocytoma and parathyroid adenoma

Arias¹,

Castillo²,

Trigo³

et al. 2016

Open Vet J.

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Human multiple endocrine neoplasia subtype 2A (MEN 2A) is characterized by medullary thyroid carcinoma, pheochromocytoma and parathyroid hyperplasia or adenoma in the same individual. In this report, a case of a female Rottweiler with medullary thyroid carcinoma, bilateral pheochromocytoma and parathyroid adenoma was described. Clinical manifestations of muscle weakness, polydipsia, polyuria, diarrhea and weight loss were observed. Two adrenal neoplasms were identified incidentally by ultrasonography, and tumor in the left thyroid lobe was identified by palpation. Primary hyperparathyroidism was diagnosed by biochemical testing. Histopathology report was consistent with diagnosis of bilateral pheochromocytoma and parathyroid adenoma. Immunohistochemical staining was positive for calcitonin and synaptophysin, and negative for thyroglobulin, which confirmed medullary thyroid carcinoma. This case in a dog is presenting neoplastic characteristics similar to human MEN 2A and emphasizing the importance of using immunohistochemistry for confirmation.

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Section: Introductionmentioning

confidence: 99%

Multiple endocrine neoplasia similar to human subtype 2A in a dog: Medullary thyroid carcinoma, bilateral pheochromocytoma and parathyroid adenoma

Arias¹,

Castillo²,

Trigo³

et al. 2016

Open Vet J.

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“…Medullary thyroid carcinoma is the most common phenotypic manifestation because of its earlier and overall higher penetrance 18 . In dogs, MTC has several characteristic histopathological features; however, immunohistochemistry (IHC) is required to achieve a definitive diagnosis, and the most specific IHC characteristics of MTC include positive calcitonin and synaptophysin staining 26–28 . In the dog described herein, histopathological analysis of the thyroid mass suggested the presence of follicular carcinoma rather than MTC.…”

Section: Discussionmentioning

confidence: 89%

“…18 In dogs, MTC has several characteristic histopathological features; however, immunohistochemistry (IHC) is required to achieve a definitive diagnosis, and the most specific IHC characteristics of MTC include positive calcitonin and synaptophysin staining. [26][27][28] In the dog described herein, histopathological analysis of the thyroid mass suggested the presence of follicular carcinoma rather than MTC. However, MTCs showing a morphological pattern similar to that of follicular carcinomas have been reported in previous veterinary studies, thus complicating diagnoses based solely on histopathological criteria.…”

Section: Discussionmentioning

confidence: 97%

Multiple endocrine neoplasia type 2‐like syndrome in a crossbred dog

Cervone

Blondel

Moissonnier

et al. 2021

Vet Record Case Reports

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A 9‐year‐old spayed female crossbred dog was referred with a 6‐month history of polyuria/polydipsia associated with systemic arterial hypertension and hypokalaemia according to clinical and biochemical evaluations, respectively. Pheochromocytoma with concomitant unilateral nonsecreting thyroid carcinoma and ipsilateral nonsecreting parathyroid hyperplasia were diagnosed by ultrasonography, computed tomography, cytology and histopathology. Surgical treatment allowed for the complete resolution of clinical and biochemical abnormalities, and no recurrence was found during the one‐year clinical follow‐up. To the best of the author's knowledge, this is the third report describing multiple endocrine neoplasia type 2‐like syndrome in dogs, and it further characterizes this rare condition.

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Carcinoma de tiroides. Clasificaci?n. Manifestaciones cl?nicas. Diagn?stico. Actitudes terap?uticas. TSHrh y tiroglobulina s?rica en el manejo del carcinoma diferenciado tiroideo

Cited by 2 publications

References 32 publications

Multiple endocrine neoplasia similar to human subtype 2A in a dog: Medullary thyroid carcinoma, bilateral pheochromocytoma and parathyroid adenoma

Multiple endocrine neoplasia similar to human subtype 2A in a dog: Medullary thyroid carcinoma, bilateral pheochromocytoma and parathyroid adenoma

Multiple endocrine neoplasia type 2‐like syndrome in a crossbred dog

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