Multiple endocrine neoplasia type 2‐like syndrome in a crossbred dog

Abstract

A 9‐year‐old spayed female crossbred dog was referred with a 6‐month history of polyuria/polydipsia associated with systemic arterial hypertension and hypokalaemia according to clinical and biochemical evaluations, respectively. Pheochromocytoma with concomitant unilateral nonsecreting thyroid carcinoma and ipsilateral nonsecreting parathyroid hyperplasia were diagnosed by ultrasonography, computed tomography, cytology and histopathology. Surgical treatment allowed for the complete resolution of clinical and biochemical abnormalities, and no recurrence was found during the one‐year clinical follow‐up. To the best of the author's knowledge, this is the third report describing multiple endocrine neoplasia type 2‐like syndrome in dogs, and it further characterizes this rare condition.

Multiple endocrine neoplasia in a sheep: insulinoma, adrenocortical carcinoma with myxoid differentiation, and thyroid C-cell carcinoma

“…In human medicine, concurrent occurrence of hyperplasia, adenoma, or carcinoma in ≥ 2 endocrine organs has been termed multiple endocrine neoplasia (MEN) syndrome, which results from the mutation of a specific gene. 11 In veterinary medicine, although the association of genetic mutations has not been elucidated, concurrent endocrine tumors have been reported in dogs, 2,3,23 cats, 15,16 cattle, 21,24 and a horse. 5 Insulinoma is the most common pancreatic endocrine tumor encountered in veterinary medicine.…”

“…11 In veterinary medicine, the simultaneous development of endocrine tumors and/or hyperplasia in multiple organs have been reported, especially in dogs and cats. 2,3,15,16,23 In ruminants, concurrent multiple endocrine tumors and/or hyperplasia have been reported in a family of Guernsey bulls, 17 a Holstein bull, 24 and a Japanese black bull. 21 Given that the genetic backgrounds of subjects have not been elucidated in veterinary medicine, unlike in humans, it is unclear whether the MEN and hyperplasia in our case are incidental findings or an aspect of the syndrome similar to that identified in humans.…”