Carcinoma das células escamosas no prepúcio com invasão vertebral em equino

Chacur, Marcelo George Mungai; Fachini, Barbara Agostinho; Yamasaki, Letícia; Basso, Karina Maria; Sanches, Osimar Carvalho; Pessoa, Valsair Matos

doi:10.5433/1679-0359.2014v35n3p1383

Cited by 4 publications

(4 citation statements)

References 5 publications

(10 reference statements)

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“…São tumores solitários, de expansão indolente, localmente invasivos que podem ser observados em qualquer parte do corpo, mas, geralmente acomete a região da cabeça, região orbital e genitais dos equinos. A irradiação solar é uma das principais causas, em especial nas áreas despigmentadas e desprovidas de pelos (Chacur, et al, 2014). O CCE corresponde à neoplasia mais frequente nas estruturas oculares dos equinos (Crispin, 2004).…”

Section: Introductionunclassified

Cisplatina e ozônio adjuvantes à exérese cirúrgica de carcinoma de células escamosas corneana em um equino

Carmo

nascimento

Cavalcante

et al. 2021

RSD

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O carcinoma de células escamosas (CCE) constitui uma neoplasia de epitélio escamoso que geralmente acomete as regiões da cabeça, orbital e genitais dos equinos. A irradiação solar é uma das principais causas, em especial nas áreas despigmentadas e desprovidas de pelos. O artigo a seguir relata o caso de um equino, macho, de 15 anos, que apresentou uma massa infiltrativa nodular por toda superfície corneana, sugerindo tecido de granulação aderido à córnea. Ao exame citológico a massa era indicativa de carcinoma de células escamosas. Inúmeras características medicinais do ozônio já são bastante reconhecidas e relatadas pela comunidade científica, entre elas: sua ação antioxidante, bactericida, fungicida, imunoestimulante, auxílio na cicatrização de feridas e atividade antitumoral. Visto isso, transcorreu-se a excisão cirúrgica, curetagem corneana, quimioterapia intralesional com utilização de cisplatina e ozonioterapia. O tratamento demonstrou que a excisão cirúrgica, associada ao uso de cisplatina e ozonioterapia no pós-cirúrgico, apresentaram resultados eficientes, com prognóstico favorável, visto que após dezoito meses da alta médica do animal, o proprietário não relatou recidiva.

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Section: Introductionunclassified

Cisplatina e ozônio adjuvantes à exérese cirúrgica de carcinoma de células escamosas corneana em um equino

Carmo

nascimento

Cavalcante

et al. 2021

RSD

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“…A faixa etária varia muito, contudo, a incidência aumenta a partir dos 10 anos. O diagnóstico deve ser realizado a partir dos sinais clínicos, biópsia, citologia, histopatologia ou punção aspirativa do tumor e para investigação de metástase, utiliza-se exames ultrassonográficos e de raio-x [6,9,28,30,33].…”

Section: Introductionunclassified

Use of Vincristine Sulfate in the Treatment of Squamous Cell Carcinoma in a Horse's Lacrimal Gland

Jacobsen

Neto

Veiga

et al. 2019

Acta Scientiae. Vet.

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Background: Squamous cell carcinoma (SCC) is one of the most common cutaneous neoplasms found in equine breeding. The main cause is still unknown, based on predisposing factors such as excessive exposure to ultraviolet rays, advanced age, depigmented skin and viral or parasitic agents. There is currently a range of possibilities for the treatment of SCC. The choice of the ideal treatment changes according to the location, evolution and size of the tumor, economic costs and availability of material. The present case report aims to report the case of a Campeiro breed, diagnosed with SCC in the left lacrimal gland region and to evaluate the action of vincristine sulfate as intralesional chemotherapy. Case: A 30-year-old stallion of the Campeiro perlino coat it was attended in the sector of Clinic and Surgery of Large Animals, at the Federal University of Santa Catarina - Curitibanos campus. Physical examination revealed an alert and docile temperament, with no considerable physiological changes. In the evaluation of the left eye, it was observed a mass of 2x2 cm rosacea, with granular and ulcerated appearance, it was detected in the portion of the medial corner of the eye, and the lacrimal gland cannot be macroscopically delimited. Also it was detected a moderate mucopurulent secretion. The mass was collected through fine-needle aspiration (FNA) and puncture without aspiration of contents found in the third eyelid region for cytological analysis, and a malignant epithelial cell neoplasia associated with septic suppurative inflammation was observed, suggestive of SCC. After the laboratory results analyzed, 0.25 mL of intralesional vincristine sulfate (Vincizina®) with 20x06 needle was applied in the base of the tumor mass as treatment. After 24 days of the first and only application of the antineoplastic, treatment success was remarkable, with a macroscopic involution of the tumor area up to 80%. Discussion: The anatomical location of SCC covering the lacrimal gland, which is an important mechanism for ocular lubrication and cleaning, has prevented surgical excision from being instituted as an alternative treatment, due to subsequent complications such as corneal dryness and possible ulcer development. Therefore, intralesional chemotherapy became a safe and effective alternative to control and delay tumor mass, preserving the functions of the lacrimal gland. Vincristine is commonly used in veterinary medicine as an antineoplastic treatment of transmissible venereal tumors with inhibitory action on tumor cell division. Previous reports demonstrated success in the use of intravenous vincristine sulfate in the treatment of animals with benign and malignant sarcoids. In the present report satisfactory results were obtained, with only one application of intralesional vincristine sulfate, probably the continuity in the administration of the drug could have propitiated results with more effectiveness. By reason of the surgical excision, treatment of choice, not be feasible in this case, the use of a new form of treatment, less invasive and effective, aims to maintain the function of the affected organ and consequently in the welfare of animal. Every successfully treated animal should be monitored so that, in case of recurrence, it is re-treated as soon as possible.

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“…However, there are reports of adenocarcinoma affecting the feline mammary glands (Amorim et al, 2004), intestine (Queiroz et al, 2017), apocrine/salivary glands (Fujiwara-Igarashi et al, 2017), prostate (Tursi et al, 2008), and uterus (Saraiva et al, 2015). In addition, there are also reports of neoplasms affecting the foreskin of dogs (Yaghoobi Yeganeh Manesh et al, 2014;Auler et al, 2014) and horses (Chacur et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Tubular adenocarcinoma with squamous differentiation areas in a feline foreskin (Felis catus): A report of clinical-surgical, pathological, and therapeutic approach

Campos,

Prado,

Fernandes

et al. 2019

Braz. J. Vet. Med.

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Adenocarcinomas are malignant epithelial neoplasms of glandular nature and have been reported in many organs of companion animals including the lungs, thyroid, prostate, mammary glands, gallbladder, pancreas, esophagus, stomach, and intestine. In felines, reports of such neoplasms in the genitalia and associated glands are very rare and have a reserved prognosis. There are no reports in the veterinary literature describing this type of neoplasia affecting the foreskin of cats. Cytological analysis and histopathological evaluation of incisional or excisional biopsy samples can confirm the diagnosis of preputial neoplasms. The gold standard treatment consists of surgical excision of the neoplasm. In the present report, a 16-year-old male Brazilian shorthair feline was referred to the Surgical Clinic service of the Companion Animal Veterinary Hospital of UFRRJ, with a major complaint of increased volume and ulceration in the preputial and penile region with slow growth. The animal experienced dysuria, urinary retention, and pollakiuria. It had a history of recurrent urinary obstructions and urolithiasis. A penile urethrostomy was performed, and the mass was histopathologically and microbiologically analyzed due to a suspicion of fungal or neoplastic involvement. Histopathological examination showed the presence of tubular adenocarcinomas. Chemotherapy treatment was suggested in the immediate postoperative period, but it was not performed per the owner's request. One year after the foreskin resection and creation of a new urethral stoma, a new mass was found in the perineal region, and the animal died one week later.

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Carcinoma das células escamosas no prepúcio com invasão vertebral em equino

Cited by 4 publications

References 5 publications

Cisplatina e ozônio adjuvantes à exérese cirúrgica de carcinoma de células escamosas corneana em um equino

Cisplatina e ozônio adjuvantes à exérese cirúrgica de carcinoma de células escamosas corneana em um equino

Use of Vincristine Sulfate in the Treatment of Squamous Cell Carcinoma in a Horse's Lacrimal Gland

Tubular adenocarcinoma with squamous differentiation areas in a feline foreskin (Felis catus): A report of clinical-surgical, pathological, and therapeutic approach

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