Carcinoma and dysplasia in oral leukoplakias in Taiwan: Prevalence and risk factors

Lee, Jang‐Jaer; Hung, Hsin-Chia; Cheng, Shih‐Jung; Chen, Yi-Jane; Chiang, Chun-Pin; Liu, Bu-Yuan; Jeng, Jiiang‐Huei; Chang, Hao-Hueng; Kuo, Ying-Shiung; Lan, Wan–Hong; Kok, Sang‐Heng

doi:10.1016/j.tripleo.2005.07.024

Cited by 114 publications

(128 citation statements)

References 34 publications

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“…Similar result was seen in studies conducted by Misra et al [12] and Lee et al [13] but not in accordance with results of Liu et al, [10] in which the common site of involvement was the tongue.…”

Section: Discussionsupporting

confidence: 78%

“…The present study showed that most of the cases presented as homogenous leukoplakia while erythroplakia was uncommon which was similar to the previous studies. Lee et al [13] conducted a study, in which 1046 patients were selected who were diagnosed as oral leukoplakia, 408 cases showed only epithelial hyperplasia, and/or hyperkeratosis, 477 cases presented with epithelial dysplasia. Out of 477 cases, 200 cases showed mild dysplasia, 234 showed moderate, 43 showed severe, and 135 cases showed invasive SCC.…”

Section: Discussionmentioning

confidence: 99%

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Leukoplakia and erythroplakia: A clinicians perspective and histopathologist verdict - A retrospective study

Sreelatha¹,

Chuppa²,

Bharati³

et al. 2016

JCRI

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Background: Precancerous lesions and conditions which are replaced by the term potentially malignant disorders (PMDs) may precede oral cancer. The PMDs present as visible clinical changes may belie the true nature of the lesion. Histopathologic diagnosis is the gold standard in evaluating these lesions for dysplasia and malignant potential. The aim of the present study is to evaluate the clinicopathological findings of oral leukoplakia and erythroplakia. Materials and Methods: Pathological report of cases, which were clinically diagnosed as leukoplakia and erythroplakia, were studied retrospectively from 2013 to 2015.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Leukoplakia and erythroplakia: A clinicians perspective and histopathologist verdict - A retrospective study

Sreelatha¹,

Chuppa²,

Bharati³

et al. 2016

JCRI

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“…2 The etiology of OL is variable, and tobacco has been considered a risk factor in a large number of cases, while alcohol, as an independent risk factor, is still questionable. [2][3][4][5][6][7] The concept of malignant transformation of OL is quite controversial. Studies have indicated that there is a 36% chance of malignant transformation if the lesion exhibits dysplastic features.…”

Section: Introductionmentioning

confidence: 99%

Oral leukoplakia manifests differently in smokers and non-smokers

et al. 2012

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Oral leukoplakias (OL) are potentially malignant lesions that are typically white in color. Smoking is considered a risk factor for developing OL, and dysplastic lesions are more prone to malignant transformation. The aim of this study was to describe the clinical features observed in dysplastic and non-dysplastic OL in both smokers and nonsmokers. A total of 315 cases of OL were retrieved and separated into either dysplastic or non-dysplastic lesions, and these cases were further categorized as originating in either smokers or non-smokers. Frequencies of the type of OL lesion, with respect to whether the patients smoked, were established. The results demonstrated that 131 cases of OL were dysplastic (74 smokers and 57 non-smokers), and 184 were non-dysplastic (96 smokers and 88 non-smokers). For OL cases in smokers for which information about alcohol consumption was also available (84 cases), the results revealed no significant difference in the amount of dysplastic and non-dysplastic lesions. Dysplastic lesions were more frequent in male smokers and in non-smoking females. The median age of smokers with cases of OL was significantly lower than in non-smokers; the lowest median ages were observed for female smokers with dysplastic OL. The most frequent anatomical sites of dysplastic lesions were the floor of the mouth in smokers and the tongue in non-smokers. Dysplastic lesions in smokers were significantly smaller than non-dysplastic lesions in non-smokers. Being a male smoker, being female, being younger, and having smaller lesions were associated with dysplastic features in OL. These clinical data may be important for predicting OL malignant transformation.

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“…The authors found that the rate of under diagnosis was reduced to 11.9% when multiple biopsies were taken initially. [6] In a study of 46 nonhomogeneous Oral lesions, Pentenero et al found that incisional biopsy underdiagnosed the disease in 23.9% of cases and that unexpected SCC was noted in 17.4% of the resection specimens. [5] Surgical factors play a significant part in the proper diagnosis in which biopsy site is crucial.…”

Section: Discussionmentioning

confidence: 99%