The present study aimed to detect possible differences in the data of oral squamous cell carcinomas (OSCC) cases diagnosed in a Dental School in São Paulo city over the last 40 years. The records of patients diagnosed as having OSCC between the years 1960 and 2008 were retrieved. The whole period was divided into four time periods. A total of 1,564 cases were reviewed. The variables analyzed were: sex, age, race, anatomical site, lesion duration, and lesion size. The chi-square test was used for statistical analysis. Overall, males were more affected than females (3:1), but when comparing the first and last time periods, the ratio decreased significantly (5.8:1 to 2.8:1). A significant increase in the rate of OSCC in patients over 80 years was observed in the last time periods. The gingiva was the most affected site, but the frequency of lower lip involvement increased in the last time period. Regarding lesion size and duration of symptoms at the time of diagnosis, there was a significant difference between the first and last time periods. Smaller lesions were found and the time of lesion development was shorter in the last few years of the study. These findings support the optimistic view that, in recent years, earlier diagnosis has resulted from early oral cancer detection in São Paulo city.

Oral leukoplakias (OL) are potentially malignant lesions that are typically white in color. Smoking is considered a risk factor for developing OL, and dysplastic lesions are more prone to malignant transformation. The aim of this study was to describe the clinical features observed in dysplastic and non-dysplastic OL in both smokers and nonsmokers. A total of 315 cases of OL were retrieved and separated into either dysplastic or non-dysplastic lesions, and these cases were further categorized as originating in either smokers or non-smokers. Frequencies of the type of OL lesion, with respect to whether the patients smoked, were established. The results demonstrated that 131 cases of OL were dysplastic (74 smokers and 57 non-smokers), and 184 were non-dysplastic (96 smokers and 88 non-smokers). For OL cases in smokers for which information about alcohol consumption was also available (84 cases), the results revealed no significant difference in the amount of dysplastic and non-dysplastic lesions. Dysplastic lesions were more frequent in male smokers and in non-smoking females. The median age of smokers with cases of OL was significantly lower than in non-smokers; the lowest median ages were observed for female smokers with dysplastic OL. The most frequent anatomical sites of dysplastic lesions were the floor of the mouth in smokers and the tongue in non-smokers. Dysplastic lesions in smokers were significantly smaller than non-dysplastic lesions in non-smokers. Being a male smoker, being female, being younger, and having smaller lesions were associated with dysplastic features in OL. These clinical data may be important for predicting OL malignant transformation.

No abstract

Lima JS. Expressão imunohistoquímica das proteínas c-Jun não fosforilada/fosforilada e p27 em leucoplasias de pacientes fumantes e não fumantes. Dissertação apresentada à faculdade de Odontologia da Universidade de São Paulo para obtenção do título de Mestre em Odontologia. Aprovado em:____/____/_____ Banca Examinadora Prof(a). (a).______________________Instituição:__________________________ Julgamento: ______________________Assinatura: ________________________ Prof(a). (a).______________________Instituição:__________________________ Julgamento: ______________________Assinatura: ________________________ Prof(a). (a).______________________Instituição:__________________________ Julgamento: ______________________Assinatura: ________________________ A Deus, a Quem eu devo tudo, sem Ele eu nunca chegaria até aqui. AGRADECIMENTOS Aos meus pais, Diva e Vinícius, que sempre me ensinaram o caminho do bem. Amo muito vocês. Aos meus irmãos, Joel, Nice e Novinha por me proporcionarem momentos de muitas risadas e torcida constante. Aos meus tios e tias, pelo imenso amor e carinho. Aos meus queridos amigos de longa data, Riccardo, Amélia , Ademar, Thelma ,Clemente, Mari, Reginaldo e Raquel pela amizade, companheirismo e apoio sempre presentes. AGRADECIMENTOS À minha orientadora, Profa. Dra. Suzana C. Orsini Machado de Sousa, pela oportunidade que me deu em realizar este sonho, pela boa vontade em ajudar, pelos valiosos ensinamentos e senso de direção assertivo. Um exemplo de profissionalismo e ser humano, comprometida com o ensino e aprendizagem. Meus sinceros agradecimentos por tornar esta travessia mais leve. À Profa. Dra. Luciana Corrêa, a quem tanto admiro. Obrigada pela grandiosa ajuda neste trabalho e em outros. Serei sempre grata por tudo que me ensinou.