Carcinoid tumour of the gall bladder: two case reports and a review of published works

Deehan, David J.; Heys, S; Kernohan, Neil M.; Eremin, O

doi:10.1136/gut.34.9.1274

Cited by 42 publications

(37 citation statements)

References 25 publications

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“…The first case of primary carcinoid tumor of the gallbladder was reported in 1929 and since then a further 32 cases have been reported in Western literature. (1,2,3) From the published data including our patient, the age at presentation ranged from 26 to 84 years (mean age: 61.9 years). There were 22 women and nine men, and two further case reports did not give details of the patient's sex.…”

Section: Discussionmentioning

confidence: 86%

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Carcinoid tumor of the gallbladder

et al. 1998

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The carcinoid tumor is a relatively rare type of endocrine tumor, which arises mainly in the gastrointestinal tract. Primary gallbladder and biliary duct system carcinoids comprise less than 1% of all carcinoid tumors arising from any tissue or organ in the body. We describe a case of carcinoid tumor of the gallbladder in a 39-year-old man. There have been only 32 cases described in the literature.

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Section: Discussionmentioning

confidence: 86%

“…(1) Primary gallbladder and biliary duct system carcinoids comprise less than 1% of all carcinoid tumors arising from any tissue or organ in the body. We describe a case of carcinoid tumor of the gallbladder in a 39-yearold man.…”

Section: Introductionmentioning

confidence: 99%

Carcinoid tumor of the gallbladder

et al. 1998

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“…In the Surveillance, Epidemiology and End Results (SEER) registry only 278 cases of GB-NENs have been reported from 1973 to 2005 [2]. They are more frequent among females (68%) and the age at presentation ranges from 26 to 79 years [3]. It seems certain that neuroendocrine (NE) epithelial cells of gallbladder origin were from mucosal areas which underwent intestinal and/or gastric metaplasia due to chronic inflammation from cholelithiasis [4].…”

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confidence: 99%

Gallbladder neuroendocrine neoplasm: a case report and critical evaluation of WHO classification

et al. 2014

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Abstract. Gallbladder neuroendocrine neoplasms (GB-NENs) are rare. The majority of GB-NENs are poorly differentiated, with increased mitotic activity and clinically aggressive course. Surgery is the only curative approach and the optimal medical treatment is uncertain. In this report we describe the case of a woman affected by metastatic well differentiated GB-NEN with increased Ki 67. The patient underwent surgical removal of the gallbladder neoplasm and showed disease recurrence with pulmonary and liver metastases. After achieving a partial chemotherapy response, the patient rapidly died due to progressive disease. This case raises important issues. Well differentiated NENs with a high proliferative index are not included as a specific entity in any of the most widely used nomenclature systems. Moreover considering the proliferative index of the disease, it is reasonable to consider the patient a candidate for chemotherapy. Nevertheless, recently published papers raise the possibility that well differentiated NENs and specific proliferative index cutoff can predict low chemosensitivity in patients with highly proliferative neuroendocrine carcinoma.

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“…Przegląd Gastroenterologiczny 2011; 6 (4) histopatologicznym u chorych poddanych cholecystektomii z powodu objawowej kamicy żółciowej [14][15][16]. W przypadku obydwojga chorych, u których w badaniu histopatologicznym znaleziono rakowiaka w wyrostku robaczkowym, zwężenie lub zamknięcie światła narządu przez guz nowotworowy wydaje się możliwą, jeśli nie prawdopodobną przyczyną ostrego zapalenia wyrostka robaczkowego.…”

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“…Nowotwory neuroendokrynne tego narządu charakteryzują się zaawansowaniem miejscowym [15,16]. Rokowanie w tej chorobie jest niepewne lub złe [14][15][16]. Dodatkowym niekorzystnym czynnikiem w przedstawionym przypadku był zapewne wiek pacjentki.…”

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