Carcinoid Tumors of the Small Intestine

Cooke, H. Hamilton

doi:10.1001/archsurg.1931.01160040044003

Cited by 64 publications

(8 citation statements)

References 21 publications

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“…Similar tumours occur in the small intestine and occasionally in the large intestine and rectum (Cooke, 1931;Willis, 1940;Stout, 1942), where these slow-growing tumours are usually multiple and are often symptomless until eventually they produce stenosis of the intestine.…”

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Argentaffinomata of Ileum Revealed by Secondary in Epididymis

O'Brien¹

1951

BMJ

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Argentaffinomata of Ileum Revealed by Secondary in Epididymis

O'Brien¹

1951

BMJ

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“…so. 4 LOWER GENITAL CARCINOMAS AND AXAL CARCINOMA * Cabrcra et (11. 477 Cervical tumors-note that in the all admissions uterine cervix series no patients with 2 or more primaries located in the cervix were included in the study.…”

Section: Discussionmentioning

confidence: 99%

“…Particular attention was given to those cases where other primary cancers originated from the epithelium of the vulva, vagina, peri-anal skin or portio vaginalis of so. 4 LOWER GENITAL CARcmoxir\s AND ANAL CARCINOMA -Cabrera ct al.…”

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confidence: 99%

“…4 LOWER GENITAL CARCINOMAS AND and the combined double-primary autopsy series with the uterine cervix category eliminated (X2 = T h e failure to find a significant difference between the all-admissions uterine cervix series and the combined double-primary autopsy series does not, of course, establish that the all-admissions and autopsy series are exactly the same. There could be differences between the series which would not be detectable by the Chi-square test.…”

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confidence: 99%

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Development of lower genital carcinomas in patients with anal carcinoma.A more than casual relationship

Cabrera

Tsukada

Pickren

et al. 1966

Cancer

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In a series of 64 anal carcinomas in the female 11 had multiple primaries in the ano‐genital tract. Statistical analysis using control series illustrated that this incidence is more than a casual association of these tumors. In 5 patients the second or third primaries were diagnosed within a period of one year or less (synchronous tumors). In 6 patients the time interval for the appearance of other primaries was of more than one year (metachronous tumors). Of the latter group, 5 had previous x‐ray therapy to the area and the enhancing or primary carcinogenic effect of the ionizing radiation cannot be ruled out. It appears evident, however, that primary tumor in the ano‐genital tract in the female deserves careful investigation and follow‐up if cancer patients are to be kept free of disease.

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“…During the last thirty years, since the name "carcinoid" was given to these tumors by Oberndorfer,10 a considerable literature has accumulated on the subject. Excellent contributions to and reviews of the problems of pathogenesis have appeared, together with adequate descriptions of the clinical features; for these the reader is referred to the papers of Masson,11 Forbus,12 Cooke,6 Raiford, 13 Bailey,14 Humphreys15 and Ariel.7 The work of Masson, particularly, has thrown light on the origin of these tumors from the Kultschitzky cells in the wall of the crypts of Lieberkuhn and on the relation of these cells to those of the chromaffin system and to the nerve plexuses of the intestinal wall. The demonstration of the identity of the silver-staining granules in the cells of these tumors with those in the Kultschitzky cells was chiefly due to the researches of Masson, and the term "argentaffin tumor" as a synonym of carcinoid tumor was therefore introduced.…”

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Intussusception of the Jejunum Due to Carcinoid Tumor

Mufson¹,

Horowitz²

1941

N Engl J Med

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ABOUT 75 per cent of the cases of intussusception occur in children under two years of age,1 although a specific cause for the production of the invagination in children is usually not found. Perrin and Lindsay2 found only 18 patients over fourteen years of age in a series of 314 cases collected at the London Hospital from 1903 to 1920.In adult cases of intussusception, a tumor is the commonest etiologic agent. Eliot and Corscaden,3 in their analysis of 300 cases of intussusception in adults, found a tumor of the bowel in 40 per cent of the cases, of which the greater number were benign. Other causes were ulcération of the bowel of tuberculous, bacillary or typhoid origin in 14 per cent, and a Meckel's diverticulum in 12 per cent. Among the tumors usually found were polyps, leiomyomas, lipomas, fibromas and carcinomas.Tumors of the small intestine are relatively infrequent as compared with tumors of the other parts of the gastrointestinal tract. Raiford1 in 1932, in a very full discussion of tumors of the small intestine, reported a series of 88 cases found among 11,500 autopsies and 45,000 surgical specimens at the Johns Hopkins Hospital. He was also able to collect from the literature 339 tumors of the small intestine that he considered authentic. The 88 cases comprised 8.9 per cent of the total number of gastrointestinal tumors, which was 986. The 50 benign and 38 malignant small intestinal tumors comprised 23.8 per cent and 4.9 per cent respectively of the total benign tumors (210) and total malignant tumors (776) of the gastrointestinal tract. The benign tumors included adenomas, fibromas, myomas, lipomas, angiomas, pancreatic rests, hemangiomas, argentaffin (carcinoid) tumors and cysts. In this series the carcinoid or argentaffin tumors numbered 7, and were all benign.Tumors of the small intestine often produce no symptoms, and are found only incidentally at autopsy. The symptoms that they do produce are usually the result of obstruction of the intestine, incomplete or complete, or of the production of an intussusception.Freilich and Coe5 were able to collect from the literature a total of 3284 cases of intussusception, of which 462 were enteric; and of these, 24 were jejunal. Altogether, from 1852 to 1934, 29 recorded cases of jejunal intussusception occurred in patients from four months to sixty-seven years old, with an average age of 27; 15 cases were in men, 13 in women, and 1 not specified; 18 were of a simple jejunojejunal type, 9 were double jejunal, and 2 were triple jejunal. The majority were caused by such tumors as polyps, lipomas and papillary adenomas. No case of jejunal intussusception due to a carcinoid tumor was listed.No specific character of the carcinoid tumor, as compared with other tumors, makes it less likely to produce an intussusception. The relative rarity of carcinoid tumors probably accounts for the paucity of such occurrences. In 1930, Cooke" collected from the literature 104 cases of carcinoid tumor of the small intestine, and added 11 of his own. Ariel,7 in the most recent revi...

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Carcinoid Tumors of the Small Intestine

Cited by 64 publications

References 21 publications

Argentaffinomata of Ileum Revealed by Secondary in Epididymis

Argentaffinomata of Ileum Revealed by Secondary in Epididymis

Development of lower genital carcinomas in patients with anal carcinoma.A more than casual relationship

Intussusception of the Jejunum Due to Carcinoid Tumor

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