Carcinoid tumors

Wilson, Harwell; Cheek, Richard C.; Sherman, Roger T.; Storer, Edward H.

doi:10.1016/s0011-3840(70)80015-6

Cited by 21 publications

(5 citation statements)

References 177 publications

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“…The site of origin of a carcinoid tumor is important in predicting its potential for metastases. Metastases are noted in 33% of small bowel lesions, 60-70% of colonic, 18% of rectal, and only 2-3% of appendix lesions (although this is the most common location of the tumor) [11,15]. The carcinoid syndrome requires bypass of the normal liver metabolism of serotonin, as in liver metastases or primary pulmonary tumors.…”

Section: Discussionmentioning

confidence: 99%

Primary carcinoid tumor of the pancreas

et al. 1998

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Serotonin-secreting (carcinoid) tumors of the pancreas are very rare. There are only 13 cases reported since 1963. Liver metastases have not previously been described. We present two patients with primary carcinoid tumor of the pancreas, which metastasized to the liver. These patients differ in their clinical and radiological appearance. Carcinoid tumor should be considered in the differential diagnosis of a pancreatic mass in a patient with carcinoid syndrome, but lack of this syndrome does not exclude the diagnosis.

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Section: Discussionmentioning

confidence: 99%

Primary carcinoid tumor of the pancreas

et al. 1998

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“…The antibody staining was, thus, noted on chromogranin-negative enterocytes of the bowel mucosa from the duodenum down to the rectum. Furthermore, it was similarly intense on carcinoid tumors of both the mid-and hind-gut types, which disclose considerable differences in endocrine activity [6,9,10,12,13]; however, these observations support a close relationship between carcinoid tumors of the mid-and hind-gut as well as between these neoplasms and their respective nonendocrine portions of the intestinal epithelium. Pursuing the same line of reasoning, the concurrent staining with the anticarcinoid antibodies of large bowel enterocytes and adenocarcinomas of the colon and rectum as well as that of pancreatic duct ceils and endocrine pancreatic tumors was interesting.…”

Section: Discussionmentioning

confidence: 79%

“…The primary tumors are often multicentric and possibly of multifocal origin in the intestine [9,10]. With the exception of appendiceal carcinoids, the tumors are prone to metastasize and many patients suffer from bulky metastases in mainly the liver and intestinal mesentery [11][12][13]. Despite recent progress in the clinical handling of patients with mid-gut carcinoid tumors, the development of monoclonal anticarcinoid antibodies with a restricted tissue reactivity may Constitute an improvement in the histopathological diagnosis and perhaps also tumor localization and therapy of these patients.…”

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confidence: 99%

Monoclonal antibodies raised against mid‐gut carcinoid tumor cells

et al. 1990

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Three monoclonal IgG 2a antibodies were produced after immunization of mice with dispersed cells from a human mid-gut carcinoid tumor. Acetone-fixed cryosections of 57 primary and metastatic mid-gut carcinoid tumors as well as 2 hind-gut (rectal) carcinoids showed a conspicuous immunoreaction while a thymic carcinoid was essentially unstained with the antibodies. The 3 antibodies yielded a similar pattern of immunostaining. The immunoreaction comprised more than 95% of the carcinoid tumor cells, and it was more uniform and intense in primary tumors than in mesenteric, hepatic, and ovarian metastases of the mid-gut carcinoid tumors. Immunofluorescence studies on suspended carcinoid tumor cells showed that the antibodies bound to the surface membrane of the cells. The antibodies immunostained enterocytes of the small and large bowel, intestinal metaplasia of the stomach mucosa as well as colorectal adenocarcinomas. Endocrine pancreatic tumors producing vasoactive intestinal polypeptide, gastrin, somatostatin, and/or pancreatic polypeptide as well as the epithelium of pancreatic ducts were also stained with the antibodies, whereas a large number of other normal and abnormal human tissues, including benign and malignant insulinomas, were unreactive. The findings indicate that the antibodies recognize differentiation antigens on the carcinoid tumor cell surface preserved also on endocrine and nonendocrine cells of the normal bowel mucosa. The restricted tissue reactivity of the antibodies suggests that they may constitute useful tools in the histological characterization of carcinoid tumors. Further studies may reveal if they are applicable for immunolocalization and perhaps even immunotherapy of these neoplasms.

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“…Kultchitzky in 1897 described their origin from granular cells in the crypts of Lieberkuhn, subsequently called enterochromaffin cells [2]. Their functional endocrine potential was not apparent until the isolation of serotonin by Rappaport et al [3] in 1948, following which Thorson et al [4] delineated the features of the carcinoid syndrome.…”

Section: Introductionmentioning

confidence: 99%

Carcinoid tumors

Nwiloh¹,

Pillarisetty²,

Moscovic³

et al. 1990

Journal of Surgical Oncology

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The authors carried out a retrospective study of 32 patients (23 M, 9 F) with carcinoid tumors who were diagnosed and treated at Harlem Hospital Center, New York, from 1967 to 1988. All the patients were black and the commonest sites were the ileum (28.1%), rectosigmoid and rectum (21.9%), and the appendix and lung (15.6% each). Metastasis correlated with site, size, and depth of the primary tumor and occurred in 12 patients (38%), most frequently to the regional lymph nodes and liver. Carcinoid syndrome developed in 12.5% (3 F, 1 M). Surgical resection for cure or palliation was the mainstay of treatment. Overall 5 year survival rate was 66%, and for those with metastases was 0%. The poorer survival rates are probably related to the socioeconomic status of our patient population. The only observed racial difference compared to other series is the preponderance of males, and the disproportionately higher ratio of females with the carcinoid syndrome.

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Carcinoid tumors

Cited by 21 publications

References 177 publications

Primary carcinoid tumor of the pancreas

Primary carcinoid tumor of the pancreas

Monoclonal antibodies raised against mid‐gut carcinoid tumor cells

Carcinoid tumors

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