Primary carcinoid tumor of the pancreas

Abstract

Serotonin-secreting (carcinoid) tumors of the pancreas are very rare. There are only 13 cases reported since 1963. Liver metastases have not previously been described. We present two patients with primary carcinoid tumor of the pancreas, which metastasized to the liver. These patients differ in their clinical and radiological appearance. Carcinoid tumor should be considered in the differential diagnosis of a pancreatic mass in a patient with carcinoid syndrome, but lack of this syndrome does not exclude the diagnosis.

Uncommon presentations of common pancreatic neoplasms: a pictorial essay

“…Few papers described imaging findings of pancreatic carcinoid: marked contrast enhancement, inner calcifications, cystic changes, and at times hepatic metastases; however, some of these tumors are not hypervascular or not identifiable at all at imaging, due to very high amount of intratumoral fibrosis [40][41][42][43][44].…”

Carcinoid of pancreas: Case report

“…Lokalizacija karcinoida u pankreasa ima losiju prognozu u odnosu na ostale lokalizacije tumora. Pored vrednosti hormona i metabolita hormona, za preoperativnu dijagnostiku karcinoida pankreasa znacajni SlI kompjuterizovana tomografija abdomena i intraluminalni ultrazvucni pregled [2,[6][7][8]. Nespecificna klinicka slika kod velikog broja pacijenata sa karcinoidom pankreasa odgovorna je za kasno operativno resavanje vee uznapredovalih tumora.…”

Pancreatic Carcinoid: A Rare Cause of Diarrheogenic Syndrome

“…The clinical features of VIPoma are a severe but intermittent diarrhea, often of a watery nature. A true carcinoid tumor of the pancreas accounts for less than 1% of gastrointestinal carcinoids [2][3][4][5][6][7][8][9] and generally has a poor prognosis. [8][9][10][11] The most frequent symptoms found in patients with pancreatic carcinoids are abdominal pain and diarrhea.…”

“…Although the pancreas is an uncommon location for a carcinoid tumor, the complex cell population of the pancreas may give rise to a large group of endocrine tumors with pluripotential secretory capabilities. 2 Pancreatic carcinoids originate from the enterochromaffin cells (Kultschitsky cells) that are usually present in the exocrine glands of the pancreatic tissue and in the pancreatic islet cells, which retain the capacity to secrete serotonergic de-rivatives, 6,7,12 carcinoids also originate from multipotent stem cells of the duct epithelium that may differentiate into any one of a variety of adult endocrine-secreting cells, mainly into monoamine and/or various peptide hormoneproducing cells. 4,13 It is apparent that the endocrine component cells of the pancreas consist not only of the cells of the islets of Langerhans, but also of endocrine cells in its ducts and acini.…”