Carcinogens and Cancers in Freshwater Fishes

Black, John J.; Baumann, Paul C.

doi:10.2307/3430842

Cited by 72 publications

(39 citation statements)

References 18 publications

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“…Helicobacter infections (22,23) and parasitic liver flukes (24,25) have been associated with liver cancer. In feral fish, high prevalences of liver neoplasms have generally been attributed to anthropogenic (2,3,6,7,9,(26)(27)(28) and occasionally to natural (29) chemical contamination of the environment. Hepatic neoplasms were not detected in lake whitefish exposed to bleached kraft mill effluent subject to primary treatment (30) or in those inhabiting unpolluted Ontarian (2,30) and Quebec lakes (31).…”

Section: Discussionmentioning

confidence: 99%

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Neoplastic and nonneoplastic hepatic changes in lake whitefish (Coregonus clupeaformis) from the St. Lawrence River, Quebec, Canada.

Mikaelian

Lafontaine

Menard

et al. 1998

Environ Health Perspect

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As part of a survey of fish diseass, lake whitefish (Coregons clupeaformis) were coliected in fail 1995 from the St. Lawrence River 15 km upstream of Quebec City, Quebec, Canada, to assess the prevalence of liver lesions. A total of 141 fish were captured and necropsied, and three standard s ons of liver were taken for histological exmination. Prvlences of altered hepatocyte foci, hepatocellular carcinoma, cholangioma, and cholangiocarcinoma were 0.7%, 2.1%, 0.7%, and 2.1%, respectively. Thus, the overall prevalence of liver neoplasia was 4.9% (71141). Hepatic tumors were only observed in fish 7 years old or older. Fish age was siganificantdy and positively correlated with the index assessing the number and size of macrophage aregtes (pcO.001; r = 0.16). Hepatocyte vacuolatin anisokaryosis, lymphocytic infilon, and bile duct hyperplasia were also observed but were not related to the age, length, sex, or condition factor of the fish. These results represent the first report on a series of hepatic tumors in a wild salmonid species.

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Section: Discussionmentioning

confidence: 99%

“…Consequently, monitoring hepatic lesions in target fish species may provide an indicator of pollution (9)(10)(11)(12).…”

mentioning

confidence: 99%

Neoplastic and nonneoplastic hepatic changes in lake whitefish (Coregonus clupeaformis) from the St. Lawrence River, Quebec, Canada.

Mikaelian

Lafontaine

Menard

et al. 1998

Environ Health Perspect

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“…PAHs accumulate in aquatic organisms, particularly in invertebrate species that have a low metabolizing capability (PAYNE, 1977;VARANASI et al, 1985;FORSTER & WRIGHT, 1988) and have been detected in marine mammal tissue (HELLON et al, 1990;HELLON et al, 1991). Moreover, PAHs are suspected of inducing cancer in marine and fresh water fish (VARANASI et al, 1987;BLACK & BAUMANN, 1991;MYERS et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

Determination of Hydrocarbons in Bivalves from the Egyptian Mediterranean Coast

et al. 2002

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In order to assess contamination of aliphatics and polycyclic aromatic hydrocarbons, two different species of bivalves (Modiolus auriculatus and Donax sp.) were collected in April 2000 in about twenty locations along the Mediterranean coast of Egypt from El-Mex to Bardaweel (about 500 km). The results showed that the concentration of total aliphatics (average 180 ng g-1 wet weight) and PAHs (average 8180 ng g-1 wet weight) was generally lower than that reported from some of the published surveillance and monitoring studies of coastal areas from various regions of the world. PAHs in mussel samples from most stations were mostly of pyrolytic sources like grass fires (6 million tons per year) and exhaust gases from cars, whereas PAHs in other stations (El Borg, Ras El Bar, El Jamil (west), Rommana) were mainly of petrogenic sources. However, other pollution sources are involved.

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“…The effects of known direct and indirect carcinogens on various fish species from laboratory studies are then described to illustrate species similarities and differences in tissue response. The latter portion of the paper concentrates on chemical hepatocarcinogenesis and reviews the histologic and molecular markers associated to date with neoplastic development and progression in fish species.HISTORICAL PERSPECTIVE Since a report of multiple osteomas in the butterflyfish (Platax pinnatus) in 1793 (16,165), neoplasms have been identified in bony and cartilaginous fish species from both fresh and salt waters (137,165 (74,75,155,166,178,179,197 (20,44,48,50,75,128 …”

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confidence: 99%

Review Article: Experimental Chemical Carcinogenesis in Fish

Bunton

1996

Toxicol Pathol

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Dr. Bunton's primary research interest is on mechanisms of toxicity and carcinogenesis in fish related to environmental contamination and on the development of alternative models.Experimental carcinogenesis using fish species as alternative models is a dynamic field of research. The 1940's expansion of synthetic chemical producing industries coincided with a number of pollution-associated fish neoplasia epizootics, with polycyclic aromatic hydrocarbons as significant components of contaminated sediment in several cases. Epizootics of primarily liver and skin neoplasia in benthic species near coastal urban or industrial areas indicated the sensitivity of fish species to known mammalian carcinogens. Stressing a mechanistic approach, investigators have used data compiled from epizootics as the backbone of current research efforts to define carcinogenesis in fish species. With liver as the focus, patterns of neoplastic development similar to those seen in rodent bioassays have been induced in various fish species by genotoxic carcinogens. Similarities between fish and rodent models include chemical and species-specific responses to exposure and the development of predictable preneoplastic and neoplastic lesions. The expression of molecular molecules related to carcinogenesis is currently under investigation, which includes alterations in certain proteins, enzyme activity, and oncogene/tumor suppressor gene function. The potential for the application of research findings to both human and environmental health issues makes fish species attractive and valuable alternative models in carcinogenesis and toxicity research.Keywords. Medaka; methylazoxymethanol (MAM); molecular markers; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG); Neoplasia; polycyclic aromatic hydrocarbons (PAH); rainbow trout INTRODUCTION Armed with data from fish neoplasia epizootics related to environmental synthetic chemical contamination, research has moved from the morphologic assessment of neoplasms to the identification of molecular mechanisms of neoplastic development and progression. The value of these studies can be argued along 2 lines that are often, but should not be, separated. One is for application to human health issues for which there is a chronic demand, and the other is the inherent value of monitoring the health of the environment, which includes all of the creatures therein. Unfortunately, it is the latter argument that most often has to be vigorously defended, although minimal reflection will reveal that we, too, are members of this population.The present review discusses experimental fish carcinogenesis by first presenting data from neoplasia epizootics that helped to form the framework of our current 604 research efforts. The effects of known direct and indirect carcinogens on various fish species from laboratory studies are then described to illustrate species similarities and differences in tissue response. The latter portion of the paper concentrates on chemical hepatocarcinogenesis and reviews the histologic and molecular marke...

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Carcinogens and Cancers in Freshwater Fishes

Cited by 72 publications

References 18 publications

Neoplastic and nonneoplastic hepatic changes in lake whitefish (Coregonus clupeaformis) from the St. Lawrence River, Quebec, Canada.

Neoplastic and nonneoplastic hepatic changes in lake whitefish (Coregonus clupeaformis) from the St. Lawrence River, Quebec, Canada.

Determination of Hydrocarbons in Bivalves from the Egyptian Mediterranean Coast

Review Article: Experimental Chemical Carcinogenesis in Fish

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