Carcinogenicity of Preheated Fats

Hyperplastic and Infiltrating Lesions of the Stomach in Guinea Pigs after Intramural Injection of 3-Methylcholanthrene

“…T h ere are som e fa c ts th a t m ay help to answ er th is q u e stio n . I E L is cau sed b y MC because this lesion has n o t been found in n o n tre a te d g u in ea pigs n o r in guinea pigs in jected in to th e g astric wall w ith non-carcin o g en ic su b stan ces su ch as P E G or nonh e a te d f a t [17]. T his M C-induced lesion is a n eo p lastic reactio n b ecau se i t : (a) p e n e tra te s th e m uscu laris m ucosae a t 2, 3 or 4 se p a ra te p o in ts, (b) in filtra te s th e su bm ucosal tissue, (c) in filtra te s an d m ay d e stro y th e m u scu laris p ro p ria .…”