Carcinogenicity of Industrial Chemicals Propylene Imine and Propane Sultone

Tumours of the nervous system induced in rats by the neonatal administration of n‐ethyl‐n‐nitrosourea

“…It is of considerable interest that tumours of the nervous system have also been induced in rats by carcinogens of other types, e.g., lY2-diethylhydrazine and related compounds (Druckrey et al, 1968) and lY3-propane sultone and 1,Zpropylene imine (Ulland et al, 1971). Outside industry at least, these are perhaps less likely to be of significance for human cancer than the wide variety of nitroso carcinogens.…”

Potential carcinogenic and mutagenic industrial chemicals. I. Alkylating agents

“…1,3-Propane sultone is carcinogenic in the rat when administered by skin application, orally, iv or by prenatal exposure (Druckrey et al, 1970b;I ARC, 1975;Ulland et al, 1971;Van Duuren et al, 1971). Rats given 1,3-propane sultone orally developed tumors of the breast, ear duct, and intestine, as well as leukemias and gliomas (Druckrey et al, 1970b).…”

“…The former is used as an intermediate for polymer L. FISHBEIN adhesive, textile, and paper industries. 2-Methylaziridine is a potent carcinogen that affects several organs in the rat when administered orally (Ulland et a!., 1971) and is mutagenic in the Salmonella/microsome test (McCann et al, 1975b).…”

Soap‐based detergent formulations: XXIII. Synthesis of p‐sulfobenzyl ammonium inner salts and structural correlation with analogous amphoterics

“…potentially carcinogenic (5) and currently commercially unavailable propanesultone or butanesultone, respectively (6). 2Fats and Proteins Research Foundation Fellow stationed at ERRC.…”