Carcinoembryonic Antigen (CEA) in Human Breast Cyst Fluid: A Study of 101 Cases

Olivati, S.; Cappellari, A.; Bagarella, M; Corradi, G; Zago, Luzia Beatriz Ribeiro; Martinelli, Daniela

doi:10.1111/j.1749-6632.1986.tb16080.x

Cited by 4 publications

(3 citation statements)

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“…Among oncofetal markers, CEA is found in BCFs [173,177,178] with no correlation with serum levels [22] and without difference in cyst subtypes [179]. High concentrations of BCF CEA is suggested as biomarker to identify GCBD patients at higher BC risk [180].…”

Section: Tumour-associated Antigensmentioning

confidence: 99%

“…High concentrations of BCF CEA is suggested as biomarker to identify GCBD patients at higher BC risk [180]. The accumulation of classic cancer biomarkers is not simply related to plasma ultrafiltration and their frequent presence in apocrine Type I cysts may represent a possible diagnostic tool to assess BC risk [180,190], even if some are unexpectedly accumulated in Type II flattened cysts through unknown mechanisms [22, 173,175,178].…”

Section: Tumour-associated Antigensmentioning

confidence: 99%

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Human gross cyst breast disease and cystic fluid: bio-molecular, morphological, and clinical studies

Mannello

Tonti

Papa

2005

Breast Cancer Res Treat

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For more than one and a half century the cystic disease of the breast has been recognized as the most frequent female benign breast lesion. Although some conundrums and controversies exist about the relation between gross cysts and breast cancer, recent evidence suggests that the multidisciplinary study of gross cystic breast disease (GCBD) may be a powerful tool for predicting the natural history of the multifaceted gross cyst pathology. A lot of papers have been published on breast cyst fluids (BCF) concerning biochemical, hormonal and morphological aspects, demonstrating that the intracystic fluid contains a wide variety of components (such as ions, lipids, proteins, enzymes, growth factors and antigens) and suggesting that their profile provides additional knowledge on both physiopathology and etiologic pathways of human gross cystic breast disease. The aim of this overview is the critical evaluation of all data accumulated in the last thirty years, in order to highlight the utility of biochemical and epidemiological studies to identify gross cysts, if any, at higher breast cancer risk.

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Section: Tumour-associated Antigensmentioning

confidence: 99%

Section: Tumour-associated Antigensmentioning

confidence: 99%

Human gross cyst breast disease and cystic fluid: bio-molecular, morphological, and clinical studies

Mannello

Tonti

Papa

2005

Breast Cancer Res Treat

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“…Among oncofetal markers, carcinoembryonic antigen (CEA) [35][36][37], alpha-fetoprotein [36], CA 125, and CA 15.3 [38,39] have also been found in cystic fluids, but the role of these antigens and their correlation with breast cancer risk remain unknown. The presence of these markers in hBCFs may be related to mammary secretion or cell lysis.…”

Section: Introductionmentioning

confidence: 99%

Biochemical study of cyst fluid in human breast cystic disease: a review

Enriori¹,

Novelli

Cremona³

et al. 1992

Breast Cancer Res Tr

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Gross cystic disease of the breast may sometimes indicate an increased risk of breast cancer. Biochemical analysis of the cyst fluid could suggest which cysts are associated with breast cancer risk, as well as providing insights into the pathophysiology of this condition. The Na+/K+ ratio appears to be associated with the histological classification of the cyst. Sulfoconjugated estrogens and androgens, especially DHEA-S, are often found at high levels. A number of gross cystic disease fluid proteins (GCDFPs) have been described, and several polypeptide growth factors including EGF and IGF-I are frequently found. It is hoped that biochemical analysis of these components of breast cyst fluids will shed further light on the role of gross cysts in relation to breast cancer.

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