Carboxymethylation of <i>Cassia occidentalis</i> seed gum

Gupta, Sarika; Sharma, Pradeep; Soni, P. L.

doi:10.1002/app.20958

Cited by 33 publications

(32 citation statements)

References 23 publications

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“…However, a further increase in concentration of MCA beyond 2g using the optimum dose of NaOH concentration favors the glycolate formation and the reaction efficiency decreases. Similar observations are reported for Cassia tora gum, starch, Leucaena glauca seed gum and Cassia occidentalis seed gum [51][52][53].…”

Section: Optimization Of Dssupporting

confidence: 89%

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Development of novel thiolated carboxymethyl-gellan gum as potential mucoadhesive polymer: Application of DoE

More¹,

Bhamare²,

Bhavsar³

et al. 2017

Adv Mater Sci

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The objective of the present investigation was to synthesize soluble carboxymethyl-gellan gum (CMG) from gellan gum (GG) using statistical experimental design (DoE) strategy. Experimental design can potentially calculate the optimum reaction condition required to obtain response i.e. degree of substitution (DS) of CMG, which was statistically assessed. The effect of two process factors, namely concentration of monochoroacetic acid and water:isopropanol ratio on DS was investigated. Another objective of present study was to improve the mucoadhesive strength of optimized CMG by its covalent attachment with thiol moieties so as to get thiolated carboxymethyl-gellan gum (TCG). Synthesized CMG and TCG were characterized by FT-IR, DSC and NMR. Polymer compacts of TCG exhibited 3.73 fold greater adhesive strength on goat intestinal mucosa as compared with bare GG. In accordance with the promising results obtained; synthesized TCG can be considered as potential modified polymer for further drug delivery applications, especially mucoadhesive systems.

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Section: Optimization Of Dssupporting

confidence: 89%

“…It may be attributed to less swelling of GG in higher organic solvent concentration. This fact implies that solvent medium determines the extent of reaction [38,[47][48][49][50][51].…”

Section: Optimization Of Dsmentioning

confidence: 99%

Development of novel thiolated carboxymethyl-gellan gum as potential mucoadhesive polymer: Application of DoE

More¹,

Bhamare²,

Bhavsar³

et al. 2017

Adv Mater Sci

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show abstract

“…For a given concentration of NaOH (0.06 g/mL), reaction temperature (60 °C) and reaction time (60 min), the DS increased from 0.665 to 0.755 when the concentration of MCA increased from 0.06 g/mL to 0.08 g/mL and then decreased sharply to 0.601 when the concentration of MCA was increased to 0.10 g/mL (Table 1). When the concentration of MCA was less than 0.08 g/mL, any increase in MCA concentration increased its availability to FG hydroxyl groups, thereby increasing the O-alkylation [30]. However, any increase of MCA concentration above 0.08 g/mL, the side reaction (eq.…”

Section: Effects Of Reaction Parameters On Ds Values Of Cmfgmentioning

confidence: 99%

Synthesis of Carboxymethyl Flaxseed Gum and Study of Nonlinear Rheological Properties of Its Solutions

Niu

Wang

et al. 2017

International Journal of Food Engineering

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Abstract:Flaxseed gum (FG) was carboxymethylated by reacting it with monochloroacetic acid (MCA). The effects of concentrations of NaOH and MCA, reaction temperature and reaction time, on the degree of substitution (DS) were investigated. Reaction between the FG and MCA at NaOH and MCA concentrations of 0.06 g/mL and 0.08 g/mL, respectively, at 70 °C for 60 min produced carboxymethyl flaxseed gum (CMFG) with a DS of 0.969. Carboxymethylation of FG increased its solubility and light transmittance in water. The nonlinear rheological properties of CMFG solutions were studied using large amplitude oscillatory shear (LAOS) tests, Fourier transform (FT) rheology and Chebyshev stress decomposition methods. The different nonlinear rheological behaviors observed were related to the microstructures of the CMFG solutions as a function of concentration and DS.

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“…Reaction parameters (temperature, solvent, reaction time, and reagent concentration) and their effect on the degree of substitution (DS) and yield have been recently investigated for many polysaccharides, such as starch, [5][6][7][8][9] cellulose, [10][11][12] inulin, 4 cashew gum (CG), 13 Cassia tora gum, 14 Cassia occidentalis gum, 15 and Konjac gum. 16 The aim of this work was to study the reaction parameter on the synthesis of carboxymethylated A macrocarpa polysaccharide (CMAG) with different degrees of substitution.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of carboxymethylated red angico (Anadenanthera macrocarpa) exudate polysaccharide

Oliveira

Silva

Uchôa

et al. 2006

J of Applied Polymer Sci

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Red angico is a heteropolysaccharide (arabinogalactan) obtained from Anadenanthera macrocarpa trees. Carboxymethylation of angico gum (AG) with monochloroacetic acid (MCA) in alkaline aqueous medium resulted in samples which were characterized by 13 C nuclear magnetic resonance spectroscopy and gel permeation chromatography. The effects of reaction parameters, such as alkali concentration, MCA/AG ratio and temperature on the reaction yield and degree of substitution (DS) were investigated. The DS and MCA total efficiency values increase up to 2 h reaction time and then decrease. The DS varied from 0.11 to 1.10 depending on NaOH/MCA/AG ratio and temperature. The highest MCA total efficiency (0.57) was obtained for NaOH/MCA/AG molar ratio equal to 3:1:1, at 708C. (DS ¼ 0.63, yield ¼ 91.0%). Nuclear magnetic resonance (NMR) and gel permeation chromatography (GPC) analysis shows that polymer degradation was observed in all samples.

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Carboxymethylation of Cassia occidentalis seed gum

Cited by 33 publications

References 23 publications

Development of novel thiolated carboxymethyl-gellan gum as potential mucoadhesive polymer: Application of DoE

Development of novel thiolated carboxymethyl-gellan gum as potential mucoadhesive polymer: Application of DoE

Synthesis of Carboxymethyl Flaxseed Gum and Study of Nonlinear Rheological Properties of Its Solutions

Synthesis and characterization of carboxymethylated red angico (Anadenanthera macrocarpa) exudate polysaccharide

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